gamma interferon activation factor
Interferon gamma mediated activation of STAT1alpha regulates growth factor induced mitogenesis
... growth factor-induced mitogenesis. In fact, PDGF and EGF receptor activation as measured by their level of tyrosine phosphorylation was not affected by IFN- g ...pretreatment. Activation of two ...
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The talented interferon gamma
... to activation of β- catenin signaling through phosphoinositide-3 kinase (PI3K) and ...this activation can also induce the expression of a Wnt inhibitor, ...hypoxia-inducible factor (HIF)-1,resulting ...
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... cell activation through simultaneous vaccination is necessary for the production of multiple ...as interferon gamma (IFNγ), tumor necrosis factor- alpha, and interleukins (IL-2, IL-6, and ...
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Activation of caprine arthritis-encephalitis virus long terminal repeat by gamma interferon.
... Caprine arthritis-encephalitis virus (CAEV) is a lentivirus that causes a symmetric, peripheral arthritis in adult goats that have been infected since birth (4, 14). Members of the lenti- virus family include human ...
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Diagnostic Implications of Antigen-Induced Gamma Interferon, Nitric Oxide, and Tumor Necrosis Factor Alpha Production by Peripheral Blood Mononuclear Cells from Mycobacterium bovis-Infected Cattle
... antigen-induced gamma interferon (IFN- ␥ ), nitric oxide (NO), and tumor necrosis factor alpha (TNF- ␣ ) responses by blood mononuclear cells from Mycobacterium bovis-infected cattle were quantified ...
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Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood Brain Barrier Leakage in Experimental Viral Encephalitis
... Disruptions to endothelial cytoskeletal organization have been speculated to be an underlying mechanism for altering junctional integrity and BBB leakage either by relaxing or contracting the intracellular interactions ...
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Dissociation of interferon-gamma production and resistance to leishmaniasis in the absence of tumor necrosis factor
... cell activation is greatly increased in the absence of TNF, however enhancement of activation as measured by increased CD44 expression does not reflect positively on the clinical ...macrophage ...
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The Association between Genetic Variation of Interferon Gamma +874 T/A and Plasma Interferon Gamma Level in Pulmonary Tuberculosis
... environmental factor, the pathogen, and genetic factors, also the interaction between the ...macrophage activation, and the formation of granuloma to prevent the spreading of Mtb ...the activation of ...
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Dissociation of interferon-gamma production and resistance to leishmaniasis in the absence of tumor necrosis factor
... 28 Significant advances in our understanding of the role of TNF in malaria have been made from studying mouse models of the disease (experimental CM, ECM), which replicate many aspects of the pathology observed in human ...
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Influence of Fiber Detargeting on Adenovirus-Mediated Innate and Adaptive Immune Activation
... immune activation in a murine model, we have characterized Ad type 5 (Ad5) vectors with two classes of chimeric fiber, CAR binding and non-CAR ...necrosis factor alpha mRNA levels resulting from Ad5 fiber ...
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Relevance of Gamma Interferon, Tumor Necrosis Factor Alpha, and Interleukin-10 Gene Polymorphisms to Susceptibility to Mediterranean Spotted Fever
... the activation of the antimicrobial activity of phagocytes as well as the intracellular killing of Rickettsia or- ganisms by the endothelial cells and the TH1-dependent im- munoglobulin G subclass production, are ...
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Differential Activation of NK Cells by Influenza A Pseudotype H5N1 and 1918 and 2009 Pandemic H1N1 Viruses
... (TLR) 2 on NK cells could also directly recognize the lipophos- phoglycan of pathogens and some viral replication products can also activate NK cells indirectly by interacting with appro- priate TLRs (3, 30). Our data ...
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Ballester López, Carolina (2019): Novel players in COPD and their molecular implication in the disease immunopathology. Dissertation, LMU München: Medizinische Fakultät
... stimulation [31,32]. In the case of macrophages, it has been shown that NICD1 regulates nuclear translocation of NFκB subunits and it is able to directly bind to TNF and INOS promoters [39,53]. However, the Notch ligands ...
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Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein
... through activation of interferon regulatory fac- tor 3 ...IRF3 activation when induced by a constitutive active form of ...transcriptional activation, as did the V protein of SeV, while the V ...
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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... I interferon signaling in IBC not only sheds light on the molecular underpinnings of the disease but also provides novel mechanisms of targeted therapy and drug resistance to be considered in the con- text of ...
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Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... of interferon (IFN)-stimulated genes ...nuclear factor B (NF- B) via the I kappa kinase (IKK) complex, thereby upregulating proinflammatory genes ...regulatory factor 3 ...
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T-helper-associated cytokines expression by peripheral blood mononuclear cells in patients with polypoidal choroidal vasculopathy and age-related macular degeneration
... Methods: Twenty-seven nAMD patients, 33 PCV patients and a gender- and age-matched group of 18 healthy individuals were involved in this study. The Th-cell cytokine profiles including levels of ...
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Recognition of herpesviruses by the innate immune system
... Activation of signal transduction in response to intracellular DNA sensing. Cytosolic DNA recognition leads to the activation of TANK-‐binding kinase 1 (TBK1), IRF3, and the production of type I IFNs and ...
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High Levels of Interferon Gamma in the Plasma of Children With Complete Interferon Gamma Receptor Deficiency
... plete interferon gamma (IFN ␥ ) receptor deficiency, un- like patients with other genetic defects predisposing them to mycobacterial diseases, have very high levels of IFN ␥ in their ...full/107/4/e48; ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... the activation of several transcription factors, including NF- B, IRF-3, and ATF-2 ...and activation requires phos- phorylation on amino acids Thr69 and Thr71 ...Following activation, these ...
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