• No results found

GATED SODIUM-CHANNEL

Novel mutations in the voltage-gated sodium channel of pyrethroid-resistant Varroa destructor populations from the Southeastern USA

Novel mutations in the voltage-gated sodium channel of pyrethroid-resistant Varroa destructor populations from the Southeastern USA

... voltage-gated sodium channel was correlated with resistance, the mutation being found at high frequency exclu- sively in hives with a recent history of pyrethroid ...

11

Regulation of voltage-gated sodium channel expression in cancer : hormones, growth factors and auto-regulation

Regulation of voltage-gated sodium channel expression in cancer : hormones, growth factors and auto-regulation

... Figure 1. Schematic diagram of the structure and membrane topology of the voltage-gated sodium channel showing the main regulatory sites. Given a-subunits have four domains (DI – DIV) each composed ...

14

Detection and quantitation of copy number variation in the voltage gated sodium channel gene of the mosquito Culex quinquefasciatus

Detection and quantitation of copy number variation in the voltage gated sodium channel gene of the mosquito Culex quinquefasciatus

... Insecticide resistance is typically associated with alterations to the insecticidal target-site or with gene expression variation at loci involved in insecticide detoxification. In some species copy number variation ...

10

Molecular dynamics of ion transport through the open conformation of a bacterial voltage gated sodium channel

Molecular dynamics of ion transport through the open conformation of a bacterial voltage gated sodium channel

... voltage-gated sodium channel pore from Magnetococcus ...the channel ’ s full ion translocation pathway and conduc- tance process, selectivity, electrophysiological characteristics, and ...

7

Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage gated sodium channel NavMs

Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage gated sodium channel NavMs

... voltage-gated sodium channel in different amphipols and detergents as a means of identifying amphipathic environments that maximally maintain the protein structure whilst providing a stabilising ...

9

Knockdown resistance (kdr) of the voltage gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia

Knockdown resistance (kdr) of the voltage gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia

... Consequently, the high usage of insecticides has gener- ated dependency of these compounds for regular vector control activities mainly during wet seasons. More import- antly, Ae. aegypti resistance to common used ...

9

Designing a C84 fullerene as a specific voltage gated sodium channel blocker

Designing a C84 fullerene as a specific voltage gated sodium channel blocker

... ion channel could lead to a new set of drug leads for the treatment of various ion channel-related ...voltage-gated sodium channel (Na v ...

8

Presence of the point mutations Val1016Gly in the voltage gated sodium channel detected in a single mosquito from Panama

Presence of the point mutations Val1016Gly in the voltage gated sodium channel detected in a single mosquito from Panama

... voltage-gated sodium channel (VGSC) protein, which causes a re- duction of the binding with the insecticide and, con- sequently, the loss of its effect [14 – ...

7

Article The role of Voltage-Gated Sodium Channel (VGSC) gene mutations in the resistance of Aedes aegypti L. to pyrethroid permethrin in Palembang and Jakarta, Indonesia

Article The role of Voltage-Gated Sodium Channel (VGSC) gene mutations in the resistance of Aedes aegypti L. to pyrethroid permethrin in Palembang and Jakarta, Indonesia

... voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti. Martins, A.J.; Lins, R.M.M; Linss, J.G.B.; Peixoto A.A.; Valle, D; Voltage gated sodi[r] ...

6

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

... voltage-gated sodium channel b2 subunit (Navb2) is a physiological substrate of BACE1 (b-site APP cleaving enzyme) and g-secretase, two proteolytic enzymes central to Alzheimer ’ s disease ...

9

Therapeutic value of voltage-gated sodium channel inhibitors in breast, colorectal and prostate cancer : a systematic review

Therapeutic value of voltage-gated sodium channel inhibitors in breast, colorectal and prostate cancer : a systematic review

... drug, sodium valproate, was shown to be, at least partially, through HDAC inhibition in several studies (Angelucci et ...2+ channel blockers verapamil and diltiazem: these drugs elicit an anticancer effect ...

12

Human voltage gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

Human voltage gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

... unusual sodium currents that have not previously been implicated in disorders of ...neuronal sodium channel ...muscle sodium channel ...cardiac sodium channel ...resurgent ...

11

Molecular basis of ion permeability in a voltage gated sodium channel

Molecular basis of ion permeability in a voltage gated sodium channel

... as sodium, and those with smaller radii ...the sodium binding sites in the AB and CD ...the channel (Appendix Fig S7A), again consistent with the electrophysiology ...As sodium is the smallest ...

12

Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior

Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior

... 30]. Sodium currents of native or transiently trans- fected CeCa cells were recorded at room temperature (20–23 °C) using an Axopatch 200B amplifier, a Digi- data 1320A/D converter, and the pCLAMP ...for ...

13

Structure of a bacterial voltage gated sodium channel pore reveals mechanisms of opening and closing

Structure of a bacterial voltage gated sodium channel pore reveals mechanisms of opening and closing

... bacterial sodium channel was determined 1 , which was in a hybrid conformation: the pore was closed at its cytoplasmic end, thus having no continuous pathway for ions to cross the membrane, but the VS was ...

9

In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis

In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis

... voltage-gated sodium channels (VGSCs) are expressed de novo in several human carcinomas where channel activity promotes a variety of cellular behaviours integral to the metastatic ...

21

Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channel of the tomato leaf miner (Tuta absoluta)

Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channel of the tomato leaf miner (Tuta absoluta)

... absoluta sodium channel gene PCR reactions were initially carried out on cDNA prepared from pools of 15 e 20 individuals from each strain using degenerate primers designed against conserved motifs within ...

9

Interactions of pyrethroids with the voltage-gated sodium channel. PhD thesis, University of Nottingham

Interactions of pyrethroids with the voltage-gated sodium channel. PhD thesis, University of Nottingham

... Maximum channel opening can be achieved by repetitive pulsing (section 5.2.2) and, therefore, the percentage of 1874M channels and para wild type channels modified by deltamethrin was ca[r] ...

277

Mutations in the voltage gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review

Mutations in the voltage gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review

... So far, kdr mutations have already been detected in at least 13 species Anopheles gambiae, Anopheles arabiensis, Anopheles sinensis, Anopheles stephensi, Anopheles subpictus, Anopheles s[r] ...

14

First detection of the kdr mutation (L1014F) in the plague vector Xenopsylla cheopis (Siphonaptera: Pulicidae)

First detection of the kdr mutation (L1014F) in the plague vector Xenopsylla cheopis (Siphonaptera: Pulicidae)

... Genomic DNA of individual fleas was isolated by the method of Rinkevich et al. [16]. Primers (Xchvgsc-F: 5 ′ -GTG CCT TGG GTA ATC TAA CGT-3 ′ and Xch- vgsc-R: 5 ′ -CGA CAA GAG CAA CGC CAA G-3 ′ ) were designed based on ...

7

Show all 10000 documents...

Related subjects