GENE THERAPY FOR LEUKEMIA
High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4 expressing retroviral vector
... Both dogs and monkeys developed leukemia approximately 2 years after transplantation. The number of integrations associ- ated with the canine leukemias (1 or 2 integrations) was lower than in the monkey (5 ...
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Targeting MicroRNAs in Cancer Gene Therapy
... With the development of genomics, miRNA expression profiles between tumor tissues and normal tissues could be rapidly established through high-throughput technologies such as gene chips, real-time PCR, etc. ...
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VIRAL BASED GENE THERAPY
... a gene for a differing transcriptase that reproduce the viral genetic material right into a double-stranded DNA ...murine leukemia virus. In trendy, retroviruses had been used for ex-vivo gene remedy ...
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A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy
... The RNA-seq data were publicly available from the TCGA website (https://tcga-data.nci.nih.gov/ tcga/). 177 AML samples stratified by leukemia French American British morphology classification (FAB) and a total of ...
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Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia
... Increased expression of ROR1 was observed in 55% of ALL patients. Based on these data, an arbitrary cut off level of 1 was defined with 100% specificity. The amount of ROR1 expression among subgroups of FAB-ALL was also ...
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Impact of DNMT3A Gene Mutation on Response of Acute Myeloid Leukemia Patients to Induction Therapy
... Complete blood counts (CBC) were performed by (ABX Micros 60, France). Peripheral blood and bone marrow (BM) smears were examined manually adopting the International Society for Laboratory Hematology (ISLH) screening ...
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Gene Therapy-Future in Regenerative Periodontics
... Periodontitis is a multifactorial disease with a broad spectrum of inflammatory and destructive responses. While microbial and environmental factors are believed to initiate and modulate periodontal disease progression, ...
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Gene therapy: progress and prospects in dentistry
... by gene therapy is its potential of transferring genetic materials to modulate speci c ...genes. Gene therapy may achieve greater bioavailability of growth factors within periodontal wounds, ...
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An insight into gene therapy the forefront of medicine
... for gene administration is limited because of fast degradation by serum nucleases and its clearance through mononuclear phagocyte system, the level of expression and limited area after naked DNA ...of gene ...
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Methylation status of DDIT3 gene in Chronic Myeloid Leukemia
... myeloid leukemia (CML) is a stem cell disease characterized by excessive accumulation of clonal myel- oid cells in hematopoietic ...fusion gene which is gener- ated by the ...
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CAR T-cell Therapy for Acute Lymphoblastic Leukemia
... CAR T-cell therapy is relatively straight forward. T-cells, which play a critical role in orchestrating an immune response, are re- sponsible for killing cells that are infected by pathogens. In order to retrieve ...
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Targeting CLL-1 for acute myeloid leukemia therapy
... suicide gene is designed in the CLL-1 CAR-T cells and can be activated by exogenous drug; a positive effect and efficiency are verified in a mouse model ...
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Characterization of secondary and therapy-related acute myeloid leukemia
... dysplasia, can be seen after a latency period of 5-7 years [74, 75]. The other classic group of t-AML arises secondary to treatment with topoisomerase II inhibitors (e.g. doxorubicin, etoposide etc.). They block the DNA ...
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Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib
... ibrutinib therapy promotes the death of CLL ...before therapy to ...ibrutinib therapy was even higher than in the blood and that tissue CLL cell death rates correlated with genetic risk factors and ...
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Gene therapy and genome surgery in the retina
... This gene encodes a myosin involved in organelle trafficking with- in the RPE that was first identified as a causative gene in Myo7a- deficient shaker-1 mice, which exhibit a shaking and head-tossing ...
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Gene Therapy In Oral Cancer : An Overview
... line therapy the germ cell, either sperm or egg is altered by the introduction of the therapeutic gene which gets integrated into their ...this therapy are manifold and ...
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Gene therapy for the treatment of cystic fibrosis
... Trials have largely been designed around molecular or electrophysiological outcome measures; very few trials attempt to achieve (or measure) clinical benefit. However, levels of CFTR mRNA and protein are low in healthy, ...
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SMaRT: A novel approach to gene therapy
... Control of the alternative splicing of FGFR2 is mediated in part through the action of polypyrimidine tract binding protein (PTB), which acts as an exon-silencing factor that may also have a role in the progression of ...
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HIV Transmission, Entry, and Gene Therapy
... The apparent eradication of HIV resulting from a ccr5Δ32 homozygous allogeneic bone marrow transplant into an HIV-infected patient represents the first reported “cure” of HIV [6]. While an important proof-of-principle, ...
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Future of adenoviruses in the gene therapy of arthritis
... local gene therapy implies that the gene will be delivered to a discrete anatomical ...arthritis gene therapy, this is normally the joint, particu- larly the synovial lining of the ...
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