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Genetic pathways

Conservation and non conservation of genetic pathways in eye specification

Conservation and non conservation of genetic pathways in eye specification

... the genetic hierarchies that control morphogenesis of the vertebrate eye, and we will compare them to the genetic pathways that control patterning of the compound eye of the fruit fly, Drosophila ...

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Functional analyses of genetic pathways controlling petal specification in poppy

Functional analyses of genetic pathways controlling petal specification in poppy

... AP3- and PI-like gene functions have been examined in monocot grasses, which lack petals. In addition to specifying stamen identity, these genes are also required for the specification of a grass-specific organ, the ...

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Identification Of Novel Molecular-Genetic Pathways Regulating The Development Of Subpallial Derivatives

Identification Of Novel Molecular-Genetic Pathways Regulating The Development Of Subpallial Derivatives

... animal models offer admittedly limited insight into the complex nature of these disorders, they may be useful in identifying molecular pathways and neural circuits that are uniquely vulnerable to genetic ...

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Light up the fly: Drosophila as a non-social model in insect sociobiology

Light up the fly: Drosophila as a non-social model in insect sociobiology

... The potential for interspecific effects of honey bee-derived social cues on the reproductive phenotype of fruit flies is a recent topic of study. First, Camiletti et al. (2013) showed that wild type Oregon R virgin ...

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Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells

Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells

... functional genetic pathways known to be of critical importance in the regulation of cellular responses to radi- ation exposure, such as response to oxidative stress, response to DNA damage stimuli, cell ...

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Bioinformatics Methods for Biochemical Pathways and System Biology Analysis

Bioinformatics Methods for Biochemical Pathways and System Biology Analysis

... the pathways and biology system for the appropriate researcher to take their ...the pathways analysis will provide the researchers with information on large scale, broad area and subjects involving the ...

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On the Role of Artificial Intelligence in Genomics to Enhance Precision Medicine

<p>On the Role of Artificial Intelligence in Genomics to Enhance Precision Medicine</p>

... ability of the genetic signature g, that depends on its predictive accuracy O ð Þ. g 82 – 84 Bayesian networks are computationally much more expensive than the Fisher, Holdout and Random samplers. 6 Besides, the ...

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Insights into Seasonal Dormancy of Perennial Herbaceous Forages

Insights into Seasonal Dormancy of Perennial Herbaceous Forages

... Genetic variation in germplasm, accurate phenotyping, and genotyping are es- sential components for successful selection. There is a limited availability of germplasm of herbaceous perennial species that has been ...

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Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

... and pathways they involve hints at a high level of molecular heterogeneity in this ...diverse pathways targeted by somatic mutation in mucinous tumors of the ovary, although further functional work is ...

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Coronary Heart Disease and Biomarkers and Its Clinical Application

Coronary Heart Disease and Biomarkers and Its Clinical Application

... and colleagues directly sequenced the low- density lipoprotein receptor (LDLR) gene in a patient with homozygous familial hypercholesterolemia and uncovered a 5k bp deletion that eliminated several exons, representing ...

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Original Article Roles of genetic variants in the PI3K/PTEN pathways in susceptibility to colorectal carcinoma and clinical outcomes treated with FOLFOX regimen

Original Article Roles of genetic variants in the PI3K/PTEN pathways in susceptibility to colorectal carcinoma and clinical outcomes treated with FOLFOX regimen

... [12]. Genetic alterations of the genes related to this pathway, including muta- tions of PI3K and PTEN, facilitate tumorigene- sis and are common in human cancers ...the genetic effect of PTEN, PIK3CA ...

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Preservation of complement induced lung injury in mice with deficiency of NADPH oxidase

Preservation of complement induced lung injury in mice with deficiency of NADPH oxidase

... Mice with chronic granulomatous disease (X-CGD mice) gen- erated by mutating the X-linked gene for a subunit of NADPH oxidase have been analyzed for their ability to respond to in- travenous injection of purified cobra ...

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PubMedCentral-PMC5542472.pdf

PubMedCentral-PMC5542472.pdf

... After establishing the application of the PKIS library to identify novel kinase pathways involved in EMT reversal, we focused on the small molecule inhibitor that had the most dra- matic effects on EMT gene ...

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Pathway-based classification of genetic diseases

Pathway-based classification of genetic diseases

... possible genetic-environmental inter- action is certainly not enough for the disease designation at the present stage of development in the fields of (cyto)genomics and molecular (systems) ...of genetic ...

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Host genetic variation impacts microbiome composition across human body sites

Host genetic variation impacts microbiome composition across human body sites

... into pathways in order to learn about the biological functions and processes that underlie interactions be- tween host genome and the ...multiple genetic effects, which could originate in different genes, ...

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Idiopathic pulmonary fibrosis and cancer: do they really look similar?

Idiopathic pulmonary fibrosis and cancer: do they really look similar?

... and genetic alterations, ab- normal expression of microRNAs (miRNAs), cellular and molecular aberrances such as the altered response to regu- latory signals, delayed apoptosis, or reduced cell-to-cell ...

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A portable expression resource for engineering cross species genetic circuits and pathways

A portable expression resource for engineering cross species genetic circuits and pathways

... Cross-species expression of the T7 RNAP and TetR also required rational design of their ribosome-binding sites and protein coding sequences. We employed multi-objective codon optimization to identify synonymous codons ...

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Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis

Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis

... Use Pathways) (PR-ST-0416-10004), BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) (MR/N027558/ 1), the FP7 projects IMAGEMEND(602450; IMAging GEnetics for MENtal Disorders) and ...

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Genes and physiology: molecular physiology in genetically engineered animals

Genes and physiology: molecular physiology in genetically engineered animals

... signaling pathways in the activation of features of hypertrophy in an in vitro model system ...embryonic genetic marker of the hypertrophic response, ...and genetic markers of hyper- trophy achieved ...

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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

... Tyrosine receptor kinases and PKA activate the Src/Ras/ Raf/MEK/ERK pathway. PKA inhibits Raf/MEK/ERK signal- ing in wild-type tubular epithelial cells, but in PKD or where intracellular calcium is reduced, PKA activates ...

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