Genome screen for SIM containing proteins
Identification of 34 Novel Proinflammatory Proteins in a Genome-Wide Macrophage Functional Screen
... these proteins are able to sensitise the cells to LPS (Fig. 2F and G, ‘‘sensitiser’’ response). Thus, genes with diverse modes of action were identified in the Raw 264.7 cell screen. However, the majority ...
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Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes
... this genome- wide RNAi screen against IBV, we have identified 83 new cellular ...our screen, the host factors identified are likely to be conserved across species and, to some extent, across ...
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Genome-wide RNAi Screen Reveals a Role for Multipass Membrane Proteins in Endosome-to-Golgi Retrieval
... a genome- wide RNAi loss-of-function screen for novel regula- tors of this trafficking pathway and report 90 genes that are required for endosome-to-Golgi retrieval of a CD8-CIMPR reporter ...
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Comparative Functional Study of Thioester-containing Related Proteins in the Recently Sequenced Genome of Biomphalaria glabrata
... the proteins studied were stable. Some of these proteins may possibly be secreted via the non-classical pathway and others through the classical ...response proteins, some of which are secretory, ...
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Genome-Wide RNAi Screen Reveals a Specific Sensitivity of IRES-Containing RNA Viruses to Host Translation Inhibition
... These findings demonstrate that both insect and mam- malian IRES-containing RNA viruses are unusually sen- sitive to levels of the ribosomal machinery. Consistent with our observation that attenuation of the ...
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A whole genome screen for HIV restriction factors
... PRRs. Proteins that interact with nucleic acids might also play a role in pat- tern ...Our screen did not identify any of the classical RNA-recognising PRRs such as toll like recep- tors TLR3, 7 or 8 or ...
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A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of ubiquitin-binding proteins Rad23 and Dsk2
... SDL screen as a new approach to identify proteolytic targets of the Rad23/ Dsk2-dependent ...SDL screen could be effective for substrate ...SDL screen to the Ub/proteasome sys- ...the screen ...
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Analysis of EF hand containing proteins in Arabidopsis
... Arabidopsis genome database and third, we searched the ...EF-hand-containing proteins in the Ara- bidopsis genome as our analysis was very ...250 proteins, only 47 have been reported in ...
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KRAB containing zinc finger repressor proteins
... those containing the Krüppel- associated box (or KRAB domain), which are present only in tetrapod ...KRAB-containing proteins are arranged in clusters in the human genome, with one cluster ...
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Crystallizing Membrane Proteins in Lipidic Mesophases A Host Lipid Screen
... Footnote 1The in meso crystallogenesis reported on herein makes use of MAGs containing cis-monounsaturated fatty acids. A shorthand system for describing the chemical constitution of these lipids is referred to as ...
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Characterization of selenium containing proteins in the coral Acropora millepora
... a systematic survey of the selenoprotein and selenium-binding protein complements of representative metazoans, and provides new perspectives on the evolution of the animal selenoproteome. In this chapter, we specifically ...
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Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila
... our screen using deficiencies greatly increases the coverage of genomic regions, there are several lim- ...region containing PD-interacting genes may not be identified from our screen if both ...
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Functional Analysis of the Dengue Virus Genome Using an Insertional Mutagenesis Screen
... nonstructural proteins are essen- tially ...these proteins and thus den- gue virus pathogenesis, we embarked on a genomewide transposon mutagenesis screen with next-generation sequencing to determine ...
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A genome scale overexpression screen to reveal drug activity in human cells
... the screen selection experiments, only a minority of hORFs protected HEK293_M2s against the cytotoxic effect of the ...volume containing 25 μl of 2× Phusion Flash High-Fidelity Master Mix (Finnzymes, Espoo, ...
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Mash Screen: high throughput sequence containment estimation for genome discovery
... translated screen Mash Screen introduces support for an amino acid alpha- bet, including 6-frame translation of the input ...Mash Screen to the commonly used translated alignment program DIAMOND ...
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A FACS-Optimized Screen Identifies Regulators of Genome Stability in Candida albicans
... Our screen identified CDC20 as the gene whose overexpression triggers the greatest increase in the frequency of ...perturb genome integrity and our observation that overexpression of ...two proteins ...
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Novel bacteriophages containing a genome of another bacteriophage within their genomes
... a screen for phages in Antarctic ...bp genome of SpaA1 is a linear, double-stranded DNA molecule with 39 protruding cohesive ends ...SpaA1 genome encompasses 63 predicted protein- coding genes which ...
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A quantitative interaction screen for neurodegenerative disease proteins
... pathogenic proteins with abnormally long polyglutamine (polyQ) tracts that irrevocably cause SCA1 or HD with full penetrance (Chung et ...misfolded proteins, since they cannot dilute toxic protein species ...
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RNA Binding Proteins and Genome Integrity
... 8. Conclusions Increasing and unexpected roles of RBPs in genome integrity have been recently recognized. Advances in analytical techniques, such as RNA deep sequencing and single cell analysis, have provided far ...
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Maintenance of genome stability by Fanconi anemia proteins
... on genome instability is crucial for advancing cancer ...the genome can handle before becoming at risk for oncogenic transformation ...from genome instability allow the evasion of apoptosis or ...
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