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Genome Wide Association Study (GWAS)

Lecture 7: Genome-wide Association Study

Lecture 7: Genome-wide Association Study

... Genome-Wide Association Study (GWAS) — 27/37 — GWAS: independent single-variant tests across all genome-wide variants • Quality control (QC) of the study dataset • Choose ...

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A genome-wide association study of bronchodilator response in asthmatics

A genome-wide association study of bronchodilator response in asthmatics

... recent genome-wide association study (GWAS) of BDR by our group identified a functional variant in the serine- rich 2-like (SPATS2L) gene, albeit the mechanism by which it regulates BDR ...

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Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.

Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.

... a genome- wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish–Swedish population of 217 children ...

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A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

... a genome-wide association study (GWAS) to identify novel genetic variants influencing nicotine metabo- ...Finns Study, FIN- RISK2007), followed by a meta-analysis of 1518 subjects, and ...

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Genome-Wide Association Study of Parity in Bangladeshi Women

Genome-Wide Association Study of Parity in Bangladeshi Women

... our genome-wide association study of number of pregnancies and number of children in Ban- gladesh did not confer strong evidence of common variants for parity ...

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Genome-Wide Association Study for Mid-Salt Tolerance in Rice

Genome-Wide Association Study for Mid-Salt Tolerance in Rice

... to study the natural variation of a worldwide japonica rice collection in response to mid-salt ...A genome wide association study (GWAS) highlighted the presence of significant loci ...

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A genome-wide association study of anorexia nervosa.

A genome-wide association study of anorexia nervosa.

... Title: A genome-wide association study of anorexia nervosa. Authors: Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM, Southam L, Rayner NW, Tachmazidou I, Klump KL, Treasure J, Lewis ...

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Semantically enabling a genome-wide association study database

Semantically enabling a genome-wide association study database

... 16. Hughes LM, Bao J, Hu ZL, Honavar V, Reecy JM: Animal trait ontology: The importance and usefulness of a unified trait vocabulary for animal species. J Anim Sci 2008, 86(6):1485 – 1491. 17. Newton-Cheh C, Johnson T, ...

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Genome wide association study of Alzheimer's disease with psychotic symptoms

Genome wide association study of Alzheimer's disease with psychotic symptoms

... Genome-wide Association Study of Alzheimer’s disease with Psychotic Symptoms Paul Hollingworth 1,16 , Robert ...Family Study Group12, Peter Holmans 1 , Lesley Jones 1 , Bernie Devlin 2 ...

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TDT for Human QTL Mapping and Genome - Wide Association Study

TDT for Human QTL Mapping and Genome - Wide Association Study

... to genome- wide association study has not been tackled so ...to genome-wide association ...linkage study for gene mapping to variable selection ...simulation ...

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A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice

A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice

... controls genome plasticity, which is important for recombination during the processes of immunity and ...the genome, yet subtle differences in the level of genomic instability can contribute to whole ...

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A genome-wide association study for corneal astigmatism: The CREAM Consortium

A genome-wide association study for corneal astigmatism: The CREAM Consortium

... Consortium. Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM ...

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A genome-wide association study on medulloblastoma.

A genome-wide association study on medulloblastoma.

... carriers of the risk allele had a more than two-fold increased risk. Our findings were not statistically significant when using the p value threshold p < 5 × 10 –8 to correct for mul- tiple comparisons. Although a ...

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A Genome Wide Association Study for  Longevity in Cattle

A Genome Wide Association Study for Longevity in Cattle

... Figure 3. Quantile-quantile plots for single SNP GWAS results without (left) and with (right) correction for population structure. For the 4887 animals and 33,556 SNPs in our study, 14 SNPs were marked as ...

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Progress of genome wide association study in domestic animals

Progress of genome wide association study in domestic animals

... Conclusions In summary, there was a great progress of GWAS in do- mestic animals and some genes for economically import- ant traits have been identified. However, the main problem lies in the inconsistencies among the ...

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Genome wide association study for multiple phenotype analysis

Genome wide association study for multiple phenotype analysis

... Discussion and conclusions The explosion in datacollection and the increasing evidence that some loci affect multiple traits require more complex statistical models for analyses to better under- stand the properties of ...

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A genome-wide association study in multiple system atrophy

A genome-wide association study in multiple system atrophy

... Conclusions: We present a GWAS in MSA. We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation ...

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Genome-wide association study of male sexual orientation

Genome-wide association study of male sexual orientation

... Study Sample. We obtained institutional review board approval from NorthShore University HealthSystem, and after a study description all enrolled subjects gave informed consent. All methods were performed ...

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Genome-wide association study in Guillain-Barré syndrome

Genome-wide association study in Guillain-Barré syndrome

... a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the ...

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Genome-wide association study of antisocial personality disorder

Genome-wide association study of antisocial personality disorder

... identical genotypes as the GWAS genotyping with 499% concordance between the two methods. In a post hoc repeat GWAS analysis, including the CRIME subjects and GenMets controls, the results were consistent with the ...

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