germ cell cancer
Early experience with chemotherapy intensification for poor prognosis metastatic germ cell cancer and unfavorable tumor marker decline
... metastatic germ cell cancer (GCC) are classified for treatment according to the International Germ Cell Consensus Classification (IGCCC) prognostic classification 1 ...
12
Canadian consensus guidelines for the management of testicular germ cell cancer
... Patients without marker elevations but with retroperi- toneal lymph nodes 1 to 2 cm, suspected to be CS IIA, rep- resent a particular problem. Differential diagnosis in these patients includes benign lymph node ...
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Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review
... Intratubular Germ Cell Carcinoma (100% of samples exhibited PARP1 overexpression), seminona ...metastatic germ cell cancer is in progress ...
9
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer
... of cell- type specific genes (Chen, 2005, Karp and Ambros, 2005, Mineno et ...including cell division, cell differentiation and cell ...in cancer (Alvarez-Garcia and Miska, 2005, ...
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ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up.
... Treatment for poor prognosis NSGCT is typically based on cisplatin-based chemotherapy and surgery (with an unclear sequence); however, due to the rarity of this disease, no level 1 evidence is available from randomised ...
178
Effectiveness of an individualized program of muscular strength and endurance with aerobic training for improving germ cell cancer related fatigue in men undergoing chemotherapy: EFICATEST study protocol for a randomized controlled trial
... group. Cancer-related fatigue, physical condition and biological samples will be measured at the beginning and at the end of an 8-week intervention by the same evaluator, who will be unaware of the allocation of ...
5
Role of epigenetics in the etiology of germ cell cancer
... regulation. Germ cell cancers (GCC) are unique because of a number of ...primordial germ cells/gonocytes that have failed ap- propriate maturation to either pre-spermatogonia or ...embryonic ...
11
The 111 Study: A Single-arm, Phase 3 Trial Evaluating One Cycle of Bleomycin, Etoposide, and Cisplatin as Adjuvant Chemotherapy in High-risk, Stage 1 Nonseminomatous or Combined Germ Cell Tumours of the Testis.
... 4. Beyer J, Albers P, Altena R, et al. Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of ...
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Fertilité après cancer du testicule
... : Long term fertility and Leydig cell function in patients treated for germ cell cancer with Cisplatin, Vinblastine and Bleomycin ver- sus surveillance.. They were evaluated retr[r] ...
5
Primordial germ cell migration
... pole cell motility may be activated via Torso (Li et ...pole cell numbers and premature activation of ...pole cell numbers and sluggish PGC migration and poor ...2. Germ cell migration ...
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Napabucasin overcomes cisplatin resistance in ovarian germ cell tumor-derived cell line by inhibiting cancer stemness
... In addition, napabucasin, an inhibitor of STAT3 signal- ing, able to decrease number of ALDH positive cells and sensitize tumor cells to cisplatin, in combination with cis- platin was investigated [37, 38]. Napabucasin ...
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Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors
... on germ cells for fertility - the propagation of our ...XY germ cell pluripotency, proliferation and quiescence must be achieved within a relative short window during human gestation: uncontrolled ...
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EFFECTIVENESS OF CHEMOTHERAPY AMONG CHILDREN WITH SOLID TUMORS: A STUDY
... Late side effects: Months or years after the fact a few children will develop late side effects from the treatment they have had. These incorporate a conceivable decrease in bone growth, an adjustment in the way the ...
7
Application of the International Germ Cell Consensus Classification to the Nova Scotia population of patients with germ cell tumours
... Between 1984 and 2004, 425 patients received diagnoses of GCT in Nova Scotia. Of these, 132 patients had metastatic disease and received platin-based chemotherapy. We excluded 3 pa- tients (1 who received prior ...
5
Nodal induces sequential restriction of germ cell factors during primordial germ cell specification
... its germ line by inductive events and that this mechanism requires Nodal signaling for the sequential restriction of cells that retain germ cell ...inductive germ cell specification in ...
9
In vitro anticancer activity of wheat germ extract on human breast cancer cell line (MCF-7) and human immortalized myelogenous leukemia cell line (K562)
... GC-MS analysis, 0.4 g of wheat germ was mixed with 4 ml of methanol-chloroform (1:1), incubated for 24h at 30C. Supernatant was decanted, centrifuged, evaporated to about ½ of initial volume in vacuum and used for ...
5
Enhancers and Suppressors of Testicular Cancer Susceptibility in Single- and Double-Mutant Mice
... Susceptibility to spontaneous testicular germ cell tumors (TGCTs), a common cancer affecting young men, shows unusual genetic complexity. Despite remarkable progress in the genetics analysis of ...
10
Diagnostic Value of Serum Prolactin in Ovarian Cancer
... malignant germ cell tumors and potentially malignant sex cord-stromal ...ovarian cancer risk is associated with parity and oral ...ovarian cancer development in comparison with nulliparity ...
7
The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms
... piR-823 in CRC is to promote cell proliferation and inhibit apoptosis. Inhibition of piR-823 arrests the cell cycle in the G1 phase within HCT116 and DLD-1 cells. Intri- guingly, inhibition of piR-823 leads ...
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Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila
... if germ cell-germ cell repulsion might confer any advantages to the ...that germ cell-germ cell repulsion serves to distribute the germ cells evenly between ...
9