Glioma Cells
Original Article A high-throughput drug screen for identifying NF-κB inhibitors to suppress proliferation of malignant brain glioma cells
... brain glioma cells was further ...malignant cells, promote angio- genesis and metastasis, subvert adaptive im- munity, and alter responses to chemotherapeu- tic agents [27-29], and inhibition of ...
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RasGRP3 regulates the migration of glioma cells via interaction with Arp3
... The cells were removed from the top of the membrane and the migratory cells were stained and ...A172 cells were transfected with control or RasGRP3 siRNA pools and the expression of the RasGRP3 ...
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Mesenchymal stem cells enhance the oncolytic effect of Newcastle disease virus in glioma cells and glioma stem cells via the secretion of TRAIL
... cancer cells. Mesenchymal stem cells (MSCs) have been reported to affect tumor growth and deliver anti-tumor agents to experimental glioblastoma ...on glioma cells and glioma stem ...
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Original Article Silencing of TIPE3 suppresses proliferation of human glioma cells via AKT signaling pathway
... To illustrate the molecular mechanism by which TIPE3 regulates the proliferation of glioma cells, western blots were performed to detect the related protein expression. As depicted in Figure 4, Silencing of ...
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Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal
... Small RNAs including antisense, siRNA, and miRNA are emerging as promising therapeutic agents against a wide array of diseases [21,23]. Effective delivery of these molecules is crucial to their successful clinical ...
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Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo
... tumors. Glioma stem cells (GSCs) which are considered the source of relapse and chemoresistance, the need for more effective therapeutic options is ...both glioma cells and ...
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ERN1 knockdown modifies the hypoxic regulation of TP53, MDM2, USP7 and PERP gene expressions in U87 glioma cells
... The glioma cell line U87 was obtained from ATCC (USA) and grown in high glucose ...this glioma cell ...of glioma cells (control glioma cells) was used as control 1 in the study ...
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MAGI3 negatively regulates Wnt/ -catenin signaling and suppresses malignant phenotypes of glioma cells
... with glioma and positively correlated with tumor grade and poor prognosis ...human glioma cells inhibits cell proliferation, tumorigenicity and invasion [7, ...
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Local Glioma Cells Are Associated with Vascular Dysregulation
... hematoxylin-stained cells across all high-power fields that contained at least 1 ...stained cells in each low-power field and computed the neuronal fraction by dividing the surface area of stained ...
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Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma
... The MT network plays important roles in nuclear translocation, subcellular localization, and egress of HSV-1 (49). The major HSV-1 tegument protein VP22 localizes on acetylated MTs and affects MT reorgani- zation during ...
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Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
... (LLC) cells than in vector control ...leukemia cells [9]. When mammalian cells contain damaged DNA, the p53 tumor suppressor and the Rb family of transcriptional repressors work together to ...
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Original Article Berberine inhibits cell growth via Wnt/beta-catenin signaling in glioma
... Abstract: Glioma is a common intracranial tumor, and the prognosis is poor, although much management is put into ...of glioma cells in ...(NC) cells were decreased significantly compared with ...
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Comparative Biology of Glioma Stem Cells and Embryonic Neural Stem Cells in Dogs.
... and binding DNA or in the formation of the protein’s tertiary and quaternary structure necessary to transactivate its target genes. The inability of mutant p53 to bind p53- response elements in effector genes of the DDR ...
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Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... two glioma cell lines (U87 glioblastoma cells and GSC11 glioma stem-like cells) were incubated in medium containing either vehicle (control) or ...U87 cells (Figure 2B and quantified ...
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Glioma stem cells-derived exosomal miR-26a promotes angiogenesis of microvessel endothelial cells in glioma
... of cells including neurons, immune cells, stem cells and cancer cells, which are considered to be one of the primary tar- gets of anti-cancer therapy due to their small sizes (40– 100 nm) ...
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Targeted therapy for glioma using cyclic RGD-entrapped polyionic complex nanomicelles
... inhibit glioma cells in vivo, Wistar rats were implanted with the C6 glioma cell line and treated with c(RGDfC) polyionic complex micelles or ...with glioma via the tail vein, setting ...
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Glioma Stem Cell Targeted Dendritic Cells as a Tumor Vaccine Against Malignant Glioma
... of glioma cells by DC-activated T cells U251 cells in the logarithmic growth phase were seeded in 96 well plates and co-cultured with T-cells and various DC combinations (BGS-DCs, ...
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Original Article miR-423-5p inhibits the proliferation and metastasis of glioblastoma cells by targeting phospholipase C beta 1
... MicroRNAs (miRNA) are a new class of noncod- ing RNAs, which regulate a variety of biological processes, and their functions are involved in cell proliferation, cell apoptosis, development, and metabolism [22-24]. ...
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Disruption of the EZH2/miRNA/β-catenin signaling suppresses aerobic glycolysis in glioma
... EZH2 is up-regulated in various cancer types, implicating its role in tumorigenesis. Our recent data have shown that repression of EZH2 inhibited glioma growth by inhibition β-catenin signaling. Here, we ...
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LPS alters the immuno-phenotype of glioma and glioma stem-like cells and induces in vivo antitumor immunity via TLR4
... and glioma cell lines. Furthermore, glioma cells and GSCs are responsive to LPS stimulation via ...in glioma cells, which prevents normal antigen recognition ...
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