Glioma Stem Cells
Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
... Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis. Here, we studied the effects of phenformin, a mitochondrial complex I inhibitor and more potent chemical analog of the diabetes drug ...
15
Mesenchymal stem cells enhance the oncolytic effect of Newcastle disease virus in glioma cells and glioma stem cells via the secretion of TRAIL
... cancer cells. Mesenchymal stem cells (MSCs) have been reported to affect tumor growth and deliver anti-tumor agents to experimental glioblastoma ...on glioma cells and glioma ...
10
Glioma stem cells-derived exosomal miR-26a promotes angiogenesis of microvessel endothelial cells in glioma
... GSCs, glioma stem cells; CAM, chorioallantoic membrane; MVD, microvessel density; ELISA, enzyme-linked immunosorbent assay; GSC agomir-NC , agomir-NC-transfected GSCs; GSC antagomir-NC , ...
15
Targeting glioma stem cells via the Hedgehog signaling pathway
... of glioma‑propagating cells in the malignancy of gliomas. These cells, also referred to as glioma stem cells (GSCs), share similarities with neural stem cells ...
9
DHHC protein family targets different subsets of glioma stem cells in specific niches
... (MES23) glioma stem cells (GSCs) transfected with the indicated plasmids in the presence or absence of PTC596 (10 μ M) treatment for 24 h (a), 72 h (b), or 2 weeks (c) ...positive cells in ...
16
Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal
... Mesenchymal stem cells (MSCs) have been shown to migrate to experimental glioma and to exert anti-tumor effects by delivering cytotoxic ...to glioma cells and glioma stem ...
16
Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells
... brain glioma is the most lethal and aggressive type of ...all glioma stem cells (GSCs) and blood– brain barrier (BBB) restricts the movement of antitumor drugs from blood to brain, thus ...
19
Original Article Comparisons between bio-radiation effects of X-rays and carbon-ion irradiation on glioma stem cells
... cancer stem cells is not completely clear. We used human glioma cancer stem cells and glioma virus-induced mice model irradiated by carbon ions or X-rays to investigate whether ...
10
Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo
... tumors. Glioma stem cells (GSCs) which are considered the source of relapse and chemoresistance, the need for more effective therapeutic options is ...both glioma cells and ...
14
RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells
... that glioma contains a minor of cells referred to as glioma stem cells(GSCs), which are characterized by their self-renewal potential and strong tumorigenic capacity ...for ...
11
Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles
... of cells in vitro (Figure 4A). Herein, glioma cancer stem cells were found to interact strongly with our gold nanoparticle-based drug delivery ...of cells, their rate of proliferation, ...
14
Comparative Biology of Glioma Stem Cells and Embryonic Neural Stem Cells in Dogs.
... of cells from G2 to mitosis (M) phase during cell division, this provides an additional level of cell cycle regulation in the p53-mediated ...eukaryotic cells with pleiotrophic effects on a wide variety of ...
294
The homing and inhibiting effects of hNSCs-BMP4 on human glioma stem cells
... to glioma pathophysiology and microenvironment [13]. Stem cells represent a delivery system that can respond to the diverse pathological signals of proliferating ...to glioma, including ...
12
Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC
... Proliferating glioma cells express ...low-grade glioma (LGG) data set to visualize the expression patterns of top 5 and bottom 5 epigenetic regulators identified in ...CIMP, glioma-CpG island ...
20
Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues
... identified glioma-promoting genes HMGA2 [20], MYO1C [21], RGS4 [22], and several novel targets, such as HPCAL1, IMPDH1, and YWHAG (Additional file 1: Table S5, orange-colored genes, Additional file 2: Figure ...
25
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.
... these cells, we next examined foci formation in the presence or absence of BMP4/serum 4 hr after 3 Gy ...differentiated cells over a repair time course of 24 hr (Figure ...with cells in standard ...
15
Expression of CD44 and CD133 in Glioma Stem Cells
... Cancer stem cells have been implicated in tumor initiation, progression, metastatic potential and resistance to ...cancer stem cell markers in different gliomas comparing to normal brain tissue and ...
7
Glioma Stem Cell Targeted Dendritic Cells as a Tumor Vaccine Against Malignant Glioma
... Cancer stem cells have recently been thought to be closely related to tu- mor development and ...malignant glioma by using glioma stem cell-targeted dendritic cells as a tumor ...
9
Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene
... embryonic stem cells (ESCs) and are thought to prime genes for activation while keeping them repressed ...cancer stem cells (CSCs), in our case, glioma stem cells (GSCs), ...
13
<p>Advances and Prospects of Vasculogenic Mimicry in Glioma: A Potential New Therapeutic Target?</p>
... endothelial cells; GCs, glioma cells; PAS, Periodic Acid-Schiff; 3D, three- dimensional; GSCs, glioma stem cells; VEGF, vascular endothelial growth factor; VEGFR-2, vascular ...
11