Glucagon-like peptide (GLP)-1
Glucagon like peptide 1 promotes satiety and suppresses energy intake in humans
... infused glucagon- like peptide 1 (GLP-1) on subjective appetite sensations af- ter an energy-fixed breakfast, and on spontaneous energy intake at an ad libitum ...breakfast, ...
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A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics
... Glucagon-like peptide-1 (GLP-1) is a hormone secreted by enteroendocrine L cells in response to ...in 1]. As such, the GLP-1 receptor (GLP-1R) has ...
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The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance
... (TBA), glucagon-like-peptide 1 (GLP-1), fibroblast growth factor 15 (FGF15), intestinal expressions of TGR5 and FXR, and correlations between them in rats with glucose ...active ...
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The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling
... Glucagon-like peptide-1 (7–36)amide (GLP-1) plays a central role in regulating blood sugar levels and its receptor, GLP-1R, is a target for anti-diabetic agents such as ...
13
Glucagon like peptide 1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
... Glucagon-like peptide-1 (GLP-1) released from the gut functions as an incretin that stimulates insulin ...secretion. GLP-1 is also a brain neuropeptide that ...
11
Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis
... of glucagon-like peptide 1 (GLP-1) to potentiate insulin secretion in pancreatic β cells, leading to decreased blood glucose level in enteroendocrinal cell lines and animal ...
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Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
... -cells, GLP-1 inhibits ATP-dependent K + channels via the cAMP-mediated PKA pathway ...of GLP-1 on myocardium observed in several studies are potentially via its G protein- coupled ...new ...
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Glucagon-like peptide-1 (GLP-1) mediates the protective effects of dipeptidyl peptidase IV inhibition on pulmonary hypertension
... as glucagon-like peptide-1 (GLP-1) ...[12]. GLP-1, an incretin hormone derived from enter- oendocrine cells, can be rapidly degraded by DPP-4, resulting in a short ...
11
GLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly?
... The glucagon-like peptide-1 (GLP-1) axis has emerged as a major therapeutic target for the treatment of type 2 ...diabetes. GLP-1 mediates its key insulinotropic ...
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Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
... that Glucagon-like peptide-1 receptor (GLP-1r) agonists, now greatly prescribed for the treatment of T2DM, have beneficial skeletal effects although the underlying mechanisms are not ...
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Glucagon-like peptide-1 (GLP-1) and protective effects in cardiovascular disease: a new therapeutic approach for myocardial protection
... of GLP-1 in myocardial protection A plethora of experimental data has been generated concerning a role of GLP-1 in diabetes, but very limited evidence has focused on its cardiovascular ...Both ...
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Exogenous glucagon like peptide 1 attenuates the glycaemic response to postpyloric nutrient infusion in critically ill patients with type 2 diabetes
... Synthetic GLP-1-(7-36) amide acetate (Bachem, Bubendorf, Germany) was reconstituted by the Royal Adelaide Hospital Department of Pharmacy, as a solution in 4% albumin and allocation concealment was ...
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Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... and GLP-1R agonists in patients with PTC, we investigated alterations in the PI3K/Akt and MAPK/Erk signaling path- ways after treating PTC cells with these ...
11
Glucagon-like peptide-1 receptor (GLP-1R) signaling ameliorates dysfunctional immunity in COPD patients
... phases: 1) detection of GLP-1R expression was carried out in a cohort of COPD patients (n = 40) and non-COPD (n = 35) subjects and 2) fluorescence-activated cell sorter (FACS) analysis of PD-1 ...
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Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
... of GLP-1 agonists have emerged recently, point- ing to a decrease of major adverse cardiovascular and cerebrovascular events (MACCE) including stroke, MI, cardiac mortality, acute coronary syndrome, and ...
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Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
... peptidase-4; GLP-1: Glucagon-like peptide-1; GIP: Glucose- dependent insulinotropic polypeptides; ECs: Endothelial cells; M6P/IGF-IIR: D-Mannose-6-phosphate/insulin-like ...
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Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.
... that glucagon-like peptide 1 receptor agonist (GLP-1RA) has an anti-hepatic fibrosis effect (Jendle J (2009), et ...of GLP-1RA. Therefore, in this study, the stimulatory effect ...
7
Design and rationale for the randomised, double-blinded, placebo-controlled Liraglutide to Improve corONary haemodynamics during Exercise streSS (LIONESS) crossover study
... acid peptide made by duodenal and jejunal enteroendocrine K cells in the proximal small bowel, was the first incretin hormone to be isolated from purified porcine intestinal extracts ...later, ...
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Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4
... the glucagon-like peptide-1 receptor (GLP-1R) as they are of β-cell origin (Reubi and Waser ...2003). GLP-1R is a G-protein coupled receptor of the class B receptor family (Zhang ...
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Further investigation of the psychometric properties of the insulin treatment appraisal scale among insulin-using and non-insulin-using adults with type 2 diabetes: results from diabetes MILES – Australia
... of glucagon-like peptide-1 (GLP-1) agonist treat- ment were excluded from the current ...study. Like insulin, GLP-1 agonist is administered via injection, ...
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