Glucocorticoid Resistance
Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells
... lation-mediated resistance to ...of glucocorticoid resistance probably reflects their distinctive significance in T cell responses ...influence glucocorticoid sensitivity through its effect on ...
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Differential network analysis and protein-protein interaction study reveals active protein modules in glucocorticoid resistance for infant acute lymphoblastic leukemia
... mediate glucocorticoid resistance in multiple myeloma, which is a cancer formed by terminally differentiated B Cells (Feinman et ...for glucocorticoid-induced apoptosis (Chandra et ...
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Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay
... for glucocorticoid therapy in animal models of sepsis was shown many decades ...in glucocorticoid therapy at a physiological dose after reports of improved response to vasopressor drugs and decreased ...
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Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells
... mediate resistance to glucocorticoids and insensitivity to JAK ...mediated glucocorticoid resistance, the top 38 KIs with z-scores ≥ 3 for at least 2/3 patients were further distinguished from ...
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Original Article Improvement effect of doxofylline on the mechanism of glucocorticoid resistance in chronic obstructive pulmonary disease rat model
... the glucocorticoid resistance phenomenon appeared, bronchial inflammation infiltration enhanced, the phe- nomenon of mucinous gland hyperplasia and many mucosal wrinkles showed no significant improvement, ...
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A semantics-oriented computational approach to investigate microRNA regulation on glucocorticoid resistance in pediatric acute lymphoblastic leukemia
... on glucocorticoid resistance in pediatric acute lymphoblastic ...regulate glucocorticoid resistance in pediatric acute lymphoblastic ...
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Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
... increased chloramphenicol acetyltransferase activity in cells expressing wild type receptor, but had no effect in cells expressing Val 641-mutant receptors, despite similar receptor concentrations, as indicated by ...
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Cushing’s syndrome with no clinical stigmata – a variant of glucocorticoid resistance syndrome
... Generalized glucocorticoid resistance is a rare disease characterized by high cortisol levels but no stigmata of Cushing ’ s ...of resistance to cortisol ...
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Does insulin resistance co-exist with glucocorticoid resistance in the metabolic syndrome? Studies comparing skin sensitivity to glucocorticoids in individuals with and without acanthosis nigricans
... applied glucocorticoid and asked whether a lack of response reflected a more gener- alized insensitivity to ...systemic glucocorticoid were more likely to demonstrate reduced skin vasoconstrictor ...
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Induction of autophagy dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
... vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor out- come in children with acute lymphoblastic leukemia ...of glucocorticoid resistance ...
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Glucocorticoid resistance in COPD patients and lung cancer
... and glucocorticoid resistance in COPD and lung cancer is considered the main ...of glucocorticoid hormones on the transcriptional activity of glucocorticoid ...of glucocorticoid ...
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Abnormal Expression and Distribution of Heat Shock Protein 90: Potential Etiologic Immunoendocrine Mechanism of Glucocorticoid Resistance in Idiopathic Nephrotic Syndrome
... disease. Glucocorticoid (GC) has powerful anti- inflammatory and immunomodulatory effects and has been used as a first-line treatment in immune-mediated/inflamma- tory ...intrinsic resistance to endocrine ...
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LPS regulates the expression of glucocorticoid receptor α and β isoforms and induces a selective glucocorticoid resistance in vitro
... This resistance to GC effects was not generalized, since the inhibitory effect on the production of IL-8 or the induc- tion of MKP-1 and FKPB-5 were maintained ...
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Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition
... of > 10 lmol/l lowering to 273 nmol/l (P < 0 0001) and a modest sensitization was also seen in the sensitive parent line, 80–24 nmol/l (P < 0 0001) (Fig 5B and C). The combi- nation index in R3F9 was indicative ...
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Unraveling the glucocorticoid receptor pathway in zebrafish
... The glucocorticoid receptor (GR) is expressed almost ubiquitously in the human body and regulates a wide range of biological processes such as our metabolism, growth, reproduction, vascular tone, bone formation, ...
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A mutation of the glucocorticoid receptor in primary cortisol resistance
... cortisol resistance have not been completely ...cortisol resistance we have observed glucocorticoid receptors (hGR) with a decreased affinity for ...hGR glucocorticoid-binding domain is the ...
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Glucocorticoid pulsatility : implications for brain functioning
... An important aspect of these studies is that in addition to c-fos and neuroendocrine re- sponses, there are also behavioural correlates to the amplitude and phase of the ultradian corticosterone pulses. We find that ...
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Let-7f-5p regulates TGFBR1 in glucocorticoid-inhibited osteoblast differentiation and ameliorates glucocorticoid-induced bone loss
... with glucocorticoid (GC)-induced osteoporosis ...that glucocorticoid receptor (GR) mediated transcriptional silencing of let-7f-5p and its knockdown enhanced Dex-inhibited osteogenic ...
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Level Of 25(OH)D Serum, Expression of Interleukin 4 And Glucocorticoid Receptor of Mononuclear Cell In Steroid Resistance Nephrotic Syndrome Children
... Nephrotic syndrome (NS) is an autoimmune disease and its steroid resistance status supposed correlate with 25(OH)D level and IL-4 expression. The aimed of this study was investigated 25(OH)D plasma level, IL-4 and ...
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Glucocorticoid induced leucine zipper (GILZ) is involved in glucocorticoid induced and mineralocorticoid induced leptin production by osteoarthritis synovial fibroblasts
... Fig. 2 Leptin secretion and leptin receptor (Ob-R) expression were induced by prednisolone and aldosterone through glucocorticoid receptor (GR) signaling. Human osteoarthritis (OA) synovial fibroblasts were ...
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