Glycerol 3-phosphate
Glycerol production in rainbow smelt (Osmerus mordax) may be triggered by low temperature alone and is associated with the activation of glycerol 3 phosphate dehydrogenase and glycerol 3 phosphatase
... to glycerol production, dihydroxyacetone phosphate (DHAP) is converted to glycerol 3-phosphate (G3P) and subsequently to glycerol via the reactions catalyzed by ...
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The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
... Consistent with AMPK’s demonstrated role in energy metabolism, AMPK has been reported to increase lipid oxidation and inhibit lipid synthesis. One proposed mechanism for AMPK induced lipid regulation is in the acute ...
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Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum
... by glycerol-3-phosphate acyltransferase (GPAT) to glycerol 3-phosphate at the sn-1 position to form lysophosphatidic acid (LysoPA) [5, ...
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Effect of diet and triiodothyronine on the activity of sn glycerol 3 phosphate dehydrogenase and on the metabolism of glucose and pyruvate by adipose tissue of obese patients
... Lipogenesis and the metabolism of sn-glycerol-3-phosphate were studied in 23 fat biopsies from eight grossly obese patients. The first biopsy was obtained after a minimum of 12 days on a 3500 cal ...
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Glycerol and neutral lipid production in the oleaginous marine diatom Phaeodactylum tricornutum promoted by overexpression of glycerol-3-phosphate dehydrogenase
... of glycerol, most of the pro- duced intracellular glycerol was not secreted from the ...overproduced glycerol in the cell, it was usually secreted to maintain the osmolality equilibrium, which is ...
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Glycerol-3-Phosphate Acyltransferases Gat1p and Gat2p Are Microsomal Phosphoproteins with Differential Contributions to Polarized Cell Growth
... Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial step in the synthesis of all glycerolipids. It is the committed and rate-limiting step and is redundant in Saccharomyces cerevisiae, ...
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Glycerol-3-phosphate acyltransferase isoforms : hepatic triacylgycerol synthesis and the development of insulin resistance
... for 3 weeks, GPAT1 -/- mice had a 60% lower hepatic TAG content than wild-type controls, and a 2-fold increase in plasma β-hydroxybutyrate concentration, indicating that lack of GPAT1 in liver altered fatty acid ...
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A novel homozygous mutation in the glycerol-3-phosphate dehydrogenase 1 gene in a Chinese patient with transient infantile hypertriglyceridemia: a case report
... GPD1 mutations were first identified by Basel-Vanagaite et al. as the cause of transient infantile hypertriglyc- eridemia (HTGTI; OMIM 614480) in 10 individuals from four consanguineous Israeli Arab families carrying a ...
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Characterization of Two Mitochondrial Flavin Adenine Dinucleotide-Dependent Glycerol-3-Phosphate Dehydrogenases in Trypanosoma brucei
... a 3-fold increase in FIG 2 Localization of tagged putG3PDH and its effect on G3PDH ...and 3) and hypotonically isolated mitochondria (lanes 2 and 4) were resolved by electrophoresis in 12% SDS gel, and ...
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INTERACTING GENES CONTROL GLYCEROL-3-PHOSPHATE DEHYDROGENASE EXPRESSION IN DEVELOPING CEREBELLUM OF THE MOUSE
... ations of the backcross data and from the strain distribution patterns among the RI mice for the heat sensitivity phenotype and the activity level phenotypes, a two-locus m[r] ...
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Molecular structure and function relationships of low activity sn-glycerol-3-phosphate dehydrogenase variants in Drosophila melanogaster
... Analyses of the Gpdh null alleles isolated from Australian natural populations by Freeth and Gibson 1985 showed that all of them produced some CRM and had low levels of GPDH activity.. T[r] ...
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GENETIC REGULATION OF SN-GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN BROWN ADIPOSE TISSUE
... Specificity of the genetic effect: Given that BALB/cJ has higher GPDH enzyme levels in BAT than do other inbred strains, it was of interest to determine if this[r] ...
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Vol. 2, Issue 10, October 2013
... The amino acid composition of lipase, fatty acid synthase and glycerol-3-phosphate dehydrogenase sequences was computed using the pepstats analysis tool [8]. The physico-chemical parameters such as ...
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RNA interference of glycerol biosynthesis suppresses rapid cold hardening of the beet armyworm, Spodoptera exigua
... catalyzes glycerol phosphorylation for utilization of glycerol (Martinez Agosto and McCabe, 2006; Stanczak et ...accumulate glycerol, GK plays a role in diapause termination to convert ...
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Effect of a high fat, high sucrose diet on the promotion of non-alcoholic fatty liver disease in male rats: the ameliorative role of three natural compounds
... of glycerol-3-phosphate dehydrogenase (G3PDH), a key lipogenic enzyme, was measured according to the method of Kozak and Jensen ...one phosphate and ...
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Re-evaluation of glycerol utilization in Saccharomyces cerevisiae: characterization of an isolate that grows on glycerol without supporting supplements
... a glycerol/H + symporter), GUT1 (encoding a glycerol kinase), and GUT2 (encoding a FAD + -dependent glycerol 3-phosphate dehydrogenase localized to the outer leaflet of the inner ...
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A study of the regulation of hepatic microsomal glycerol phosphate acyltransferase (GPAT) : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University
... 1 977 ) . Fatty acid s synthesi sed de novo are ester i fi ed to glycerol 3-phosphate and r etained in the li ver or packaged into VLDL whi ch are secreted into the blood . Fatty acids from dietary ...
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Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B
... GPDM: Glycerol-3-phosphate dehydrogenase, mitochondrial; GPI: Glucose-6-phosphate isomerase; GRB2: Growth factor receptor-bound protein 2; GRP75: Stress-70 protein, mitochondrial; GTP: ...
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Elucidating redox balance shift in Scheffersomyces stipitis’ fermentative metabolism using a modified genome-scale metabolic model
... GLYC3P: glycerol-3-phosphate; GEM: genome-scale metabolic model; gCDW: gram cell dry weight; LO: line of optimality (objective function is cell growth unless specified otherwise); NAD(+): ...
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Chapter 5 guided reading notes
... 34. To summarize, a phospholipid has a glycerol attached to a phosphate group and two fatty acid chains. The head is hydrophilic, and the tail is hydrophobic. Now, sketch the phospholipid bilayer structure ...
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