glycogen synthase kinase 3 β
BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT
... inactivated glycogen synthase, the final enzyme in glycogen ...The β isoforms show a substantial deviation in protein sequence, mostly outside the kinase core (308 residues), but the ...
12
Inhibitory interactions of Coenzyme Q10 with selected key enzymes of glucose metabolism: An in silico approach
... human glycogen synthase kinase 3-β, α-glucosidase, human aldose reductase and alpha ...showed 3 hydrogen bond interactions with human glycogen synthase ...
6
The crossroads of breast cancer progression: insights into the modulation of major signaling pathways
... GSK3 β , Glycogen synthase kinase 3 β , G βγ , G beta-gamma complex; HDAC1, Histone deacetylase 1; HDM2, Human double minute 2 protein; IFN, Interferon; IGF1, Insulin-like growth ...
34
Protein arginine methylation: an emerging regulator of the cell cycle
... GSK3β: glycogen synthase kinase 3 β; H: histidine; hnRNPUL1: heterogenous nuclear ribonucleo protein; INCENP: inner cen- tromere protein; INK4: inhibitors of CDK4; JMY: junction ...
16
Activation of GABAB receptors inhibits protein kinase B /Glycogen Synthase Kinase 3 signaling
... of β-arrestin2 to the D2R and specific dephosphorylation/inactivation of the serine/ threonine kinase Akt on its regulatory Thr-308 residue but not the second regulatory residue (Ser-473) ...of ...
10
Glycogen synthase kinase 3 is essential for β arrestin 2 complex formation and lithium sensitive behaviors in mice
... Overexpression of Gsk3b reverses lithium-sensitive behaviors. Rescue of a gene knockout or drug-induced phenotype by restoring activ- ity of the putative target provides strong support for the hypoth- esis that the ...
8
Glycogen synthase kinase-3 is required for axon growth and development
... protein kinase B (PKB, aka Akt) causes GSK-3 inactivation. GSK-3 also plays a key inhibitory role in the canonical Wnt ...phosphorylates β-catenin, thereby targeting it for ubiquitylation and ...
60
Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment
... GSK3- β : Glycogen synthase kinase 3-beta; HIF-1 α : Hypoxia-inducible transcription factor-1 α ; I/R: Ischemia reperfusion; IPC: Ischemic preconditioning; IPostC: Ischemic ...
14
Plasma 25-hydroxyvitamin D is related to protein signaling involved in glucose homeostasis in a tissue-specific manner
... of glycogen synthase kinase-3 (GSK-3) α Ser21 and β Ser9 in skeletal muscle (r = − ...and β Ser9 phosphorylation in adipose tissue (r = ...protein kinase-B (Akt ...
9
Download Download PDF
... and β-glucose decreased, those of lactate and low-density lipoproteins increased, and the expression of multiple amino acids was ...of glycogen synthase kinase 3 beta (GSK3β) and ...
10
Activation of mTOR: a culprit of Alzheimer’s disease?
... by β-amyloid (Aβ) production and the hyper-phosphorylation of tau in basic ...upregulating β- and ...phosphoinositide 3-kinase (PI3-K)/protein kinase B (Akt), glycogen ...
16
Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin
... The specific effects of these small molecule inhibitors against GSK-3β activity are described in previous studies [23, 24]. These studies reported that while the biochemical IC 50 values of AR-A014418 and SB-216763 are ...
14
Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer
... Protein assays were performed according to the Bradford method using a Bio-Rad protein assay kit (Bio-Rad Labo- ratories Inc., Hercules, CA, USA). Denatured proteins were separated using 10% sodium dodecyl ...
8
Novel Roles for the Tumor Suppressor APC Through Regulation of GSK-3
... reduced β-catenin phosphorylation by GSK-3 and thus reduced β-catenin ubiquitination and degradation which leads to β-catenin accumulation and constitutive activation of Wnt target ...1998). ...
157
Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway
... Fig. 3 Identification of clustering cells. a Western blot from the cortical neurons cultured for 5 days after treatment with vehicle or AF. AF‑treated cells showed a significant increase in neural stem or ...
10
Regulation of Flagellar Assembly by Glycogen Synthase Kinase 3 in Chlamydomonas reinhardtii
... The kinase activity of GSK3 has been shown both in vivo and in vitro to be directly and indirectly inhibited by lithium (26, ...the 3⬘ untranslated region containing the Chlamydomonas polyadenylation signal ...
13
Search | Preprints
... [22] Cheng, W. H.; Lu, P. J.; Ho, W. Y.; Tung, C. S.; Cheng, P. W.; Hsiao, M.; Tseng, C. J. Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate ...
37
Strategies for derivation of endothelial lineages from human stem cells
... As reported by Orlova et al. [37], differentiation was initiated by the culture of hESCs on a Matrigel-coated surface in mTeSR1 culture medium supplemented with BMP4, VEGF-A (low dose), activin A, and CHIR for 3 ...
14
The traditional Chinese formulae Ling gui zhu gan decoction alleviated non alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules
... affect glycogen metabolism [8], which is the primary storage form of excess ...mediate glycogen metabolism ...to glycogen (PTG) [10]. PTG overexpression can increase glycogen storage ...
11
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling
... Abstract: Burkitt’s lymphoma (BL) is an aggressive disorder associated with extremely high rates of cell proliferation tempered by high levels of apoptosis. Despite the high levels of cell death, the net effect is one of ...
12