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glycogen synthesis kinase-3β

The traditional Chinese formulae Ling gui zhu gan decoction alleviated non alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules

The traditional Chinese formulae Ling gui zhu gan decoction alleviated non alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules

... affect glycogen metabolism [8], which is the primary storage form of excess ...mediate glycogen metabolism ...to glycogen (PTG) [10]. PTG overexpression can increase glycogen storage ...

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Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway

Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway

... of glycogen and lipids is the primary means by which the body stores excess nutrients and is strictly controlled by a complex network of hormones and metabolic ...conditions, glycogen is the primary storage ...

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Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal

Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal

... serine/threonine kinase that regulates a variety of cellular functions including glycogen synthesis, metabolism, proliferation, differentiation, apoptosis, in- sulin signaling, and decision of cell ...

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Characterization of the Interaction between Latency-Associated Nuclear Antigen and Glycogen Synthase Kinase 3β

Characterization of the Interaction between Latency-Associated Nuclear Antigen and Glycogen Synthase Kinase 3β

... The major cellular function of pVHL is to target the tran- scription factors hypoxia-inducible factor-1 ␣ (HIF-1 ␣ ) and hy- FIG. 4. Effect of LANA on the stability and half-life of various cellular proteins. (a) LANA ...

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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE 3β INHIBITORS AS ANTIDIABETIC AGENTS

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE 3β INHIBITORS AS ANTIDIABETIC AGENTS

... novel Glycogen Synthase Kinase- inhibitors to overcome insulin resistance in type 2 diabetes mellitus and to overcome associated health problems with reducing morbidity, mortality and economic ...

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Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload

Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload

... Cell culture. Rat and mouse neonatal ventricular car- diomyocytes (12) and Jurkat T lymphocytes (13) were isolated and cultured as described. Following serum starvation for 18 hours, cells were stimulated with ...

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Glycogen Synthase Kinase-3β (GSK-3β) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia

Glycogen Synthase Kinase-3β (GSK-3β) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia

... The primers used in the experiments were de- signed using the Primer Quest web tool (Integrat- ed DNA Technologies, Inc., Los Angeles, USA) and synthesized in the Unit of Synthesis and DNA Se- quencing, Institute ...

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Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells

Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells

... AKT is known to cause downstream mTOR activation [1], and since mTOR increases translation of many pro- teins, we tested if mTOR was responsible for the increased p21 levels in the urothelial cell lines stimulated with ...

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Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin

Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin

... is glycogen synthase kinase- (GSK-), a serine/threonine protein kinase that maintains homeostasis in normal cells by regulating several fundamental biological pathways [9, ...

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Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A

Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A

... Airway smooth muscle (ASM) hyperplasia is a key feature of airway remodeling in development of lung diseases such as asthma. Anomalous proliferation of ASM cells directly contributes to ASM hyperplasia. However, the ...

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Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats

Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats

... As shown in previous studies, GSK- partici- pates in subcellular translocation of Nrf2 to the nu- cleus. Nrf2, which is a key factor in the oxidative stress response [11], regulates expression of phase II ...

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AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury

AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury

... Previous studies, including results obtained in our laboratory, have shown that enhanced AMPK activa- tion diminished the severity of lung injury in experimental models of sterile inflammation, such as after exposure of ...

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In Silico Analysis of Glycogen Synthase Kinase 3-Beta (GSK-3β) As Aflatoxin Binder

In Silico Analysis of Glycogen Synthase Kinase 3-Beta (GSK-3β) As Aflatoxin Binder

... of glycogen synthase kinase by curcumin/ : Investigation by simulated molecular docking and subsequent in vitro / in vivo ...N., Glycogen synthase ...

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Modulation of glycogen synthase kinase-3β following TRAIL combinatorial treatment in cancer cells

Modulation of glycogen synthase kinase-3β following TRAIL combinatorial treatment in cancer cells

... RPMI and DMEM, DMEM F12 tissue culture media, Lipofectamine 2000 and β-galactosidase assay kit were purchased from Invitrogen; the luciferase Assay Reagent from Promega (Madison, WI); Troglitazone, TRAIL and ...

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Glycogen synthase kinase 3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

Glycogen synthase kinase 3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

... identify glycogen synthase kinase-3 (GSK-3) as the pivotal kinase that serves as this point of protection-signaling integra- tion, as it is known to receive inputs from each of these pathways, which ...

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The bile acid synthetic gene 3β hydroxy Δ5 C27 steroid oxidoreductase is mutated in progressive intrahepatic cholestasis

The bile acid synthetic gene 3β hydroxy Δ5 C27 steroid oxidoreductase is mutated in progressive intrahepatic cholestasis

... gressive liver disease. He weighed 4 kg at birth and exhib- ited jaundice 2 days later. He was brought to clinical attention in Great Britain as a 3-month-old infant (3). He had moderate jaundice, hepatomegaly, and an ...

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The redox sensitive glycogen synthase kinase 3β suppresses the self-protective antioxidant response in podocytes upon oxidative glomerular injury

The redox sensitive glycogen synthase kinase 3β suppresses the self-protective antioxidant response in podocytes upon oxidative glomerular injury

... more glycogen particles, which were mainly located to the cellular body and major processes of glomerular podocytes, closely associated with the network of tubules of the smooth endoplasmic reticulum, and appeared ...

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Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3β) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies

Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3β) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies

... Deoxycytidine kinase; DLBCL: Diffuse large B-cell lymphoma; FBS: Fetal bovine serum; FL: Follicular lymphoma; GSK3 β : Glycogen synthase kinase; HSD: Honestly significant difference; IACUC: ...

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Accumulation of Cytoplasmic β-Catenin and Nuclear Glycogen Synthase Kinase 3β in Epstein-Barr Virus-Infected Cells

Accumulation of Cytoplasmic β-Catenin and Nuclear Glycogen Synthase Kinase 3β in Epstein-Barr Virus-Infected Cells

... -OH kinase (PI3K) signaling, and notch ...regulating kinase, glycogen synthase kinase 3 ␤ (GSK3 ␤ ), was shown to be phosphorylated and inactivated in EBV-infected ...

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Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer

Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer

... In contrast, GSK-3 b activation decreased cell proliferation of breast cancer cells [13], prostate cancer cells [14], and colon cancer cells [15] as well as survival of prostate cancer c[r] ...

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