Gold thioglucose induced hypothalamic obesity in mice:
Two defects contribute to hypothalamic leptin resistance in mice with diet induced obesity
... 2000. Obesity in humans and in rodents is usually associated with high circulating leptin levels and leptin ...induce hypothalamic STAT3 (signal transducer and activator of transcription) signaling in ...
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Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity
... Obtained brain tissue sections were set on MALDI- appropriate stainless steel plates (GMS-Thermo, CA, USA) and then coated with a 10 mg/mL (50% methanol to acetonitrile) solution of alpha-cyano-4-hydroxycin- namic acid ...
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Cellular source of hypothalamic macrophage accumulation in diet-induced obesity
... test hypothalamic vascular permeability, 3% Evans blue diluted in saline (Sigma, #E2129, 10 ml/kg) was ad- ministered via a tail vein to mice fed with a CD or an HFD for the indicated periods (n = ...
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Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity
... diet-induced obesity, the present data seem to indicate that the diet- induced obese mice maintained their obesity despite apparently decreased caloric intake and increased caloric ...
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Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype
... Six-week-old male Swiss mice fed on chow were anes- thetized with a mixture of ketamine (100 mg/kg) and xylazine (10 mg/kg) perfused with saline and 4% parafor- maldehyde. The brain was totally removed and kept in ...
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Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice
... HFD-induced hypothalamic metaflammation and microgliosis while normalizing hypo- thalamic Agrp expression and the anorexigenic response to exogenous leptin, despite ongoing exposure to ...of ...
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Obesity is associated with hypothalamic injury in rodents and humans
... of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy ...of obesity, ...
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Hypothalamic Inflammation in Obesity, Insulin Resistance and Ageing
... cognition induced by HFD consumption (Lu et ...improves hypothalamic insulin sensitivity after HFD consumption reducing NFκB, p- IκB and pJNK levels in mice (Melo et ...HFD-fed mice (Wu et ...
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Mice lacking the syndecan 3 gene are resistant to diet induced obesity
... including hypothalamic nuclei, which are known to regulate energy ...syndecan-3–null mice have reduced adipose content compared with wild-type ...female mice exhibited a partial resistance to ...
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ANTI OBESITY ACTIVITY AND BENEFICIAL EFFECTS OF METHANOLIC EXTRACT OF DESMOSTACHYA BIPINNATA IN HFD AND PROGESTERONE INDUCED OBESITY IN RATS AND MICE
... progesterone induced hyperphagia by inhibiting reuptake of 5- HT (serotonin) at the hypothalamic site which regulate the food intake, which suggests the possible interaction exists between the neurosteroid ...
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Ventromedial hypothalamus–specific Ptpn1 deletion exacerbates diet induced obesity in female mice
... In contrast, in the VMH, leptin negatively regulates FI, promot- ing weight loss, whereas insulin suppresses EE, leading to weight gain. Ptpn1 deletion in VMH SF-1 neurons causes increased leptin sensitivity and reduced ...
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Obesity-linked dysfunction of hypothalamic and pituitary circuits in regulation of energy homeostasis
... in hypothalamic phospho-STAT3 immunoreactivity after leptin stimulation ...and hypothalamic diacylglyerol concentration is aggravated by a high-fat diet (182, ...189). Mice with loss-of-function ...
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Studies on gold thioglucose lesion formation and glucose oxidation in the ventromedial hypothalamus
... behavioral systems, and feedii% behavior is not an exception. Insulin, estrogen and glucocorticoids, substances that influence carbohydrate metabolism, can produce changes in feeding [r] ...
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PARP1 deficiency exacerbates diet-induced obesity in mice
... diet-induced obesity in humans ( Comuzzie & Allison 1998 ) as well as among various inbred strains of mice ( Brockmann & Bevova 2002 ...of obesity phenotype in ...induce obesity ...
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Hypothalamic inflammation in obesity and metabolic disease
... of obesity and associated co-mor- ...sustained hypothalamic inflammatory processes via interactions between neurons and non-neuronal cell populations, perpetuating these initially reversible process- es and ...
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Alteration of hypothalamic cellular dynamics in obesity
... from obesity and one or more of its adverse complications is rapidly ...how obesity affects the structure of the ...of obesity on neurons and glia in the ...that obesity may be in part due to ...
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Impaired Suppression of Sympathetic Activity during Fasting in the Gold Thioglucose treated Mouse
... J Clin Invest. 1980;65(5):1086-1094. https://doi.org/10.1172/JCI109761. Sympathetic activity in rats and mice is diminished by fasting and increased by sucrose feeding. The central neural mechanisms coordinating ...
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Evaluation of Anti-obesity Effect of Fattolin, a Polyherbal Formulation in Progesterone Induced Obesity in Mice
... of obesity but not reported ...progesterone induced obesity model. Female Swiss albino mice were divided in four groups (n=6) and treated for 28 days, Group I received 2% gum acacia (10 ...
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Paradoxical resistance to diet induced obesity in UCP1 deficient mice
... of mice lacking the mitochondrial uncoupling protein UCP1, has provided an oppor- tunity to analyze the relationship between the capacity for energy expenditure and the development of obesity in response to ...
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Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity
... Due to the size range, 20–30 nm of the AuNPs used in this study, it is estimated that they would preferentially be eliminated via the reticuloendothelial system such as liver and spleen, with limited excretion through ...
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