Growth differentiation factor-15 (GDF-15)
A meta-analysis of genome-wide association studies of growth differentiation Factor-15 concentration in blood
... Growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), is a stress response cytokine and a divergent member of the transforming ...
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Original Article Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer
... on growth inhibi- tion and apoptosis of BGC-823 ...in growth differentiation factor-15 (GDF-15) was verified by qRT-PCR and Western ...of GDF-15 in gastric ...
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Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells
... migration, growth and chemo-resistance of tumor cells in several solid tumors, including human prostate, pancreatic, colo- rectal carcinoma, and in hematologic malignancies, such as multiple myeloma, and the ...
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Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells
... Growth differentiation factor-15 (GDF15), a TGF- β / bone morphogenetic protein (BMP) superfamily mem- ber, is a 40-kDa secretory propeptide that is cleaved in the endoplasmic reticulum to ...
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Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis
... of GDF-15 improves atherosclerotic plaque stability by impairing macrophage migration and inducing collagen ...that GDF-15 and TGF- signaling in macrophages partly overlap but also that ...
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Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease
... 5]. Growth and differentiation factor 15 (GDF- 15), previously known as macrophage inhibitory cytokine 1 (MIC-1), is a divergent transforming growth factor β ...
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Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo
... However, GDF-15 expression was not associated with fi bre type within the muscle nor was there an association of serum GDF-15 with fi bre ...in GDF-15 expression observed and that ...
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Preoperative plasma growth differentiation factor 15 for prediction of acute kidney injury in patients undergoing cardiac surgery
... and GDF-15 both reflect circulatory stress [20, 21], supporting the role of this factor as a trigger of AKI in this ...increased GDF-15 levels on renal function has not been shown so ...
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Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease
... human GDF-15 levels in crude serum, we adopted commercial enzyme-linked immunosorbent assay (ELISA) kits purchased from R&D (Quantikine, R&D Systems, USA) (Catalog Number: DY957, DY008) with intra- ...
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Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest
... baseline GDF-15 (logarithm transformed) con- stituted an independent predictor of poor neurological ...baseline GDF-15 levels could predict poor neurological outcome at 6 ...
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Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study
... for GDF-15 were collected before coronary angi- ...of GDF-15 were centrifuged immediately after collection and were stored at −80 °C until ...measurement. GDF-15 plasma concen- ...
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Growth differentiation factor 15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study
... of GDF-15 is only 20 ...of GDF-15 as a biomarker for the identification of PVD in patients with ARDS may have been obscured in our ...because GDF-15 measurements were obtained at ...
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Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis
... serum GDF-15 levels were found to be significantly increased in patients with ulcerative ...in GDF-15 may reflect increased erythropoiesis in these patients in response to ...
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Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood
... of GDF-15, a sensitive marker of cardiopulmonary stress that in other settings predicts re- duced long-term survival, and of IL-10, IL-15, sICAM and ...
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GDF-15 protects from macrophage accumulation in a mousemodel of advanced atherosclerosis
... transforming growth factor-β (TGF-β) superfamily have been shown to contribute to the development of vascular inflammation ...cently, growth differentiation factor-15 ...
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Dynamic derangement in amino acid profile during and after a stroke like episode in adult onset mitochondrial disease: a case report
... measured growth differentiation factor-15 and multiple amino acids in his blood, longitudinally during and after the stroke-like ...episode. Growth differentiation ...
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<p>Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma</p>
... In this study, we aimed to explore the role of GDFs in GBM. In our preliminary analysis, GDF15 and MSTN were identi fi ed as candidate tumor-promoting genes in GBM. GDF15 has been shown to play a crucial role in the ...
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Growth differentiation factor 9 and bone morphogenetic protein 15 expression in previtellogenic oocytes and during early embryonic development of Yellow-tail Kingfish Seriola lalandi
... rapid growth rate, good flesh quality and an increasing worldwide ...of growth factors gdf9 and bmp15 in previtellogenic oocytes and during early em- bryonic development in ...
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Investigation of polymorphic variation in the growth differentiation factor-9 gene (GDF9) in New Zealand sheep breeds
... Chi-square analysis revealed that Corriedale and South Down breeds had variant pools that were significantly different from the other breeds sampled, Figure 15 and Table B. 2. The frequency of the two variants in ...
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A genetic association study between growth differentiation factor 5 (GDF 5) polymorphism and knee osteoarthritis in Thai population
... Our study has shown the statistically significant associa- tion between polymorphism in promoter of GDF5 gene ( rs143383 ) and knee osteoarthritis in Thai population. We found that T allele in GDF5 polymorphism was a ...
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