GSK-3
Issues associated with the use of phosphospecific antibodies to localise active and inactive pools of GSK-3 in cells
... of GSK-3 isoforms, we addressed questions about the selectivity of the different anti-phosphorylated GSK-3 ...for GSK-3 during spindle dynamics, as pre- viously reported by ...
9
(R)-(+)-α-Lipoic acid protected NG108-15 cells against H<sub>2</sub>O<sub>2</sub>-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines
... of GSK-3 β resulted in the suppression of proinflammatory cytokines with subsequent mitigation of mitochondrial-mediated caspase-dependent neuronal ...targeting GSK-3 β through PI3K-Akt would ...
16
<p>Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway</p>
... TYR activity and melanin content in B16 cells treated with D206008; opposite effects were seen with the Akt inhibi- tor IV. In conclusion, D206008 promotes melanogenesis via the Akt/GSK-3 β / β -catenin ...
10
Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
... (e.g., GSK-3β) is challenging due to the conserved nature of the ATP-binding sites across the kinase ...fide GSK-3 substrates but not possible to include that in the present ...on GSK-3 ...
23
Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β
... that GSK-3 β is involved in the degradation of HIF-1 α indicated similarities with the destruction of β -catenin in the canonical Wnt signaling ...pathway, GSK-3 β and β -catenin are part of a ...
11
Increase in Subcellular GSK-3 Clusters in Insulin- and Adrenaline-treated Differentiated Rat Skeletal Muscle Fibres
... above, GSK-3 has complex regula- tion both upstream and ...of GSK-3 (Patel and Woodgett, ...regulating GSK-3 and physiological processes, and the finding in the present study ...
8
Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa
... 25]. GSK-3 plays a pivotal role in the regulation of peripheral and central pro- inflammatory cytokine production [26, 27], and its inhibition reduces both systemic and brain inflammation [26, ...upon ...
10
GSK-3 inhibitors induce chromosome instability
... different GSK- 3 inhibitors effect spindle morphology and chromosome alignment, and elevate the chromosomes missegregation ...of GSK-3β by RNA interference yielded similar effects. We focussed on ...
17
Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway
... The numerous studies support the concept that activity of GSK-3 α and GSK-3 β is involved in cell fate, including in neuronal proliferation and differentiation [12–14]. So, we next observed ...
10
Novel Roles for the Tumor Suppressor APC Through Regulation of GSK-3
... 143 Wang, Z., Yang, H., Zhang, F., Pan, Z., Capo-Aponte, J., and Reinach, P.S. (2009b). Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation. Invest ...
157
Identification of GSK-3 as a potential therapeutic entry point for epilepsy
... towards GSK-3 inhibition as the anticonvulsant mechanism of action of indirubin, a possible involvement of CDKs cannot be ...excluded. GSK-3 shares indeed many functional properties with CDKs ...
35
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK 3 inhibition in a mouse model of lithium therapy
... of GSK-3 in the developing nervous system (67), and assuming a parallel between the effect of GSK-3 deletion in embryonic and adult neurogenesis, replacement by new neurons seems ...Briefly, ...
15
Original Article Biological and clinical significance of GSK-3 in mantle cell lymphoma–an immunohistochemical study
... evidence of constitutive activation of the Wnt canonical pathway in MCL cell lines and patient tumours, which is likely to be attributed to the autocrine and/or paracrine stimulation of vari- ous Wnt ligands including ...
10
Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats
... of GSK-3β, P-GSK-3β, β-catenin, and Cyclin D1 protein by Western blot assay in order to further in- vestigate the effect of the signaling attenuation after transplantation in rats with oral tracheal ...
14
An ensemble method approach to investigate kinase-specific phosphorylation sites
... B = 15, and B = 20. The result shows that a very small varia- tion in accuracy is found in most of the kinases, including PKA, PKC, MAPK, CDK1, CK2, CAM KII, and SRC, with the change of B. The kinase families PKB and ...
15
Glycogen synthase kinase-3β inhibition induces nuclear factor-κB-mediated apoptosis in pediatric acute lymphocyte leukemia cells
... of GSK-3 b in nuclei of ALL cells prompted us to examine the effect of GSK-3 b inhibition on NF- B ...of GSK-3b: SB216763 (ATP-competitive, arylindolema- leimide) [11], and LiCl ...
8
Glycogen synthase kinase 3 is essential for β arrestin 2 complex formation and lithium sensitive behaviors in mice
... between GSK-3 and the b-arrestin-2 complex in mice and propose an integrated mechanism that accounts for the effects of lithium on multiple ...behaviors. GSK-3b (Gsk3b) overexpression reversed ...
8
Structure–activity relationships in a series of antiplasmodial thieno[2,3 b]pyridines
... kinase GSK-3 ...of GSK-3 ...of GSK-3 inhibitors were devel- oped as potential drugs ...of GSK-3 in mammalian organisms led to speculations about the function of ...
10
CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer
... blocking GSK-3 β phosphorylation at Ser9 ...suppresses GSK-3 β phosphorylation. GSK-3 β phosphorylation is mediated by several kinases, including AKT, protein kinase A (PKA) and ...
9
Regulation of Akt and Wnt signalling by the dopamine D2 receptor and metabotropic glutamate receptor 2/3
... There are three mammalian isoforms of Dvl denoted Dvl-1, Dvl-2 and Dvl-3. All three isoforms are expressed in the brain and all three isoforms regulate GSK-3. The exact mechanism concerning how Dvl ...
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