HA, hemagglutinin
Influenza Hemagglutinin (HA) Stem Region Mutations That Stabilize or Destabilize the Structure of Multiple HA Subtypes
... viral hemagglutinin (HA) that drive the membrane fusion ...the HA is metastable, and the pH of fusion can vary significantly among HA strains and ...implicates HA stability properties ...
13
Hemagglutinin (HA) Proteins from H1 and H3 Serotypes of Influenza A Viruses Require Different Antigen Designs for the Induction of Optimal Protective Antibody Responses as Studied by Codon-Optimized HA DNA Vaccines
... The hemagglutinin (HA) gene is modified to eliminate high virulence associated with the cleav- age site of the HA, allowing the virus to replicate to high titers in eggs (15, 24, 26, 34, 35, 48, ...
10
1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in Mice
... the hemagglutinin (HA) gene in efficient replication and high virulence of the 1918 virus in ...virus HA gene is required for 1918 virus to exhibit high virulence in ...virus HA, we ...
16
Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin
... I nfluenza viruses cause respiratory infections in humans, result- ing in severe disease in millions of individuals annually and high mortality during pandemics, such as the 1918 “Spanish Flu” pan- demic. Entry of ...
6
Re emergence of H3N2 strains carrying potential neutralizing mutations at the N linked glycosylation site at the hemagglutinin head, post the 2009 H1N1 pandemic
... of HA gene of A/Okayama/6/01 (H3N2) was prepared by RT-PCR and cloned into the pPolI vector designated as pPolI-Oka/6/01-wt (code named H3-0) in our pre- vious study ...constructing HA mutant plasmid ...
12
A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication
... To determine the amino acid residues in NS5A responsible for specific interaction with FKBP8, Flag- FKBP8 was coexpressed with C-terminal deletion mutants of the hemagglutinin HA-tagged [r] ...
10
Morphological and Biochemical Characterization of the Membranous Hepatitis C Virus Replication Compartment
... a hemagglutinin (HA) affinity tag in nonstructural protein 4B (NS4B), the supposed scaffold protein of the viral replication ...using HA-specific affinity purification we isolated NS4B-contain- ing ...
16
N-Glycosylation of Seasonal Influenza Vaccine Hemagglutinins: Implication for Potency Testing and Immune Processing
... containing HA used in influenza vaccine potency ...and HA-specific glyco- peptide glycosylation patterns were ...in HA antigen ...any HA antigen glycosylation status from any cell ...
22
Hemagglutinin Typing as an Aid in Identification of Biochemically Atypical Escherichia coli Strains
... thesis, University of Dundee, Scotland, 1980, possessed a mannose-sensitive MS hemagglutinin HA that agglutinated fowl and guinea pig erythrocytes in the absence, but not in the presence[r] ...
5
In vitro enhancement of human natural cell-mediated cytotoxicity by purified influenza virus glycoproteins.
... 839 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The role of the glycoproteins of influenza virus, hemagglutinin HA, and neuraminidase NA in the in vitro stimulation[r] ...
7
Early Alterations of the Receptor-Binding Properties of H1, H2, and H3 Avian Influenza Virus Hemagglutinins after Their Introduction into Mammals
... virus hemagglutinin (HA) after interspecies transmission and to determine the amino acid substitutions responsible for these alterations, we studied the HAs of the initial isolates from the human pandemics ...
11
Membrane Structures of the Hemifusion-Inducing Fusion Peptide Mutant G1S and the Fusion-Blocking Mutant G1V of Influenza Virus Hemagglutinin Suggest a Mechanism for Pore Opening in Membrane Fusion
... might contribute to their activity. Gly 1, Phe 3, Ala 5, Ala 7, Gly 8, Phe 9, Glu 11, Gly 13, Trp 14, Gly 16, and Trp 21 of HA2 are absolutely conserved in all strains of influenza virus (14). This includes four glycines ...
12
Highly conserved antigenic epitope regions of hemagglutinin and neuraminidase genes between 2009 H1N1 and seasonal H1N1 influenza: vaccine considerations
... H1 hemagglutinin trimer of strain A/801/2009 was obtained using ...pH1N1 HA protein referred to that of the sH1N1 HA protein in IEDB ...sH1N1 HA protein in IEDB ...
8
Identification of eight determinants in the hemagglutinin molecule of influenza virus A/PR/8/34 (H1N1) which are recognized by class II-restricted T cells from BALB/c mice.
... CATON The Wistar Institute ofAnatomy and Biology, 3601 Spruce Street, Philadelphia, Pennsylvania 191044268 Eight nonoverlappimg regions of the hemagglutinin HA molecule of influenza viru[r] ...
9
Differing Epidemiological Dynamics of Influenza B Virus Lineages in Guangzhou, Southern China, 2009-2010
... Collection of clinical specimens, virus culture, and sequencing. Na- sopharyngeal and/or throat swab samples were collected from 205 sub- jects with acute respiratory infection or community-acquired pneumonia who were ...
10
Sequence Analysis and Phylogenetic Study of Hemagglutinin Gene of H9N2 Subtype of Avian Influenza Virus Isolated during 1998-2002 in Iran
... subtypes: hemagglutinin (HA) and neura-minidase (NA) ...15 HA (H1-15) and 9 NA (N1-9) subtypes among the influenza A viruses [1, ...4]. HA is the major antigen for neutralizing antibodies and ...
6
Separation and Characterization of Soluble Adenovirus Type 9 Components
... These were a complete hemagglutinin HA, an incomplete HA, components carrying group-specific comple'ment-fixing CF antigen, and components identified only by their hemagglutination-inhib[r] ...
8
The Matrix Gene Segment Destabilizes the Acid and Thermal Stability of the Hemagglutinin of Pandemic Live Attenuated Influenza Virus Vaccines
... the HA protein, allowing the use of a ther- mostability assay as a measure of HA stability (40, 48, ...The HA titer of the ca viruses decreased more rapidly than that of the wt viruses, suggesting ...
11
An Inactivated, Adjuvanted Whole Virion Clade 2.2 H5N1 (A/Chicken/Astana/6/05) Influenza Vaccine Is Safe and Immunogenic in a Single Dose in Humans
... In this study, we assessed in humans the immunogenicity and safety of one dose (7.5 or 15 g of hemagglutinin [HA]) of a whole-virion inactivated prepandemic influenza vaccine adjuvanted with aluminum ...
6
Neutralizing Epitopes of Influenza Virus Hemagglutinin: Target for the Development of a Universal Vaccine against H5N1 Lineages
... in hemagglutinin (HA) sequences, the principal determinant of immunity to influenza virus, re- sulting in different lineages or clades of H5N1 (13, ...the HA sequences, particularly within the ...
9