hairpin polyamides
Shape selective recognition of the DNA minor groove by hairpin polyamides
... Figure 5.2 Experimental design for evaluation of novel N-terminal residues…..135 Figure 5.3 Synthesis of N-terminal thiophene building blocks…………………...136 Figure 5.4 Synthesis of hairpin ...
18
Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides
... that hairpin polyamides which incorporate an N-terminal Nt unit (PA3–4) in- duce more pronounced compression of the major groove of target DNA duplexes compared to archetypical hair- pin PIPs and untethered ...
12
Improving the Biological Activity of Pyrrole-Imidazole Polyamides
... to hairpin polyamides with alternative heterocycle composition and DNA-binding preferences (15-20), uptake of polyamide-FITC conjugates was well-correlated with cytotoxicity and gene regulatory effects, ...
211
Synthesis and Biological Studies of DNA binding Cyclic Py Im Polyamides
... Pyrrole-imidazole polyamides are a class of synthetic ligands that can be programmed to bind the minor groove of specific DNA ...unit, hairpin Py-Im polyamides can be programmed to bind a large ...
176
Antitumor Activity of Py-lm Polyamides
... Py-Im polyamides as non- genotoxic antitumor agents that are active against prostate cancer ...two hairpin polyamides targeted to the 5’-WGWWCW-3’ sequence found in the androgen response ...4 ...
97
Detection of DNA by sequence specific fluorescent polyamides
... the hairpin, and alkyl units b- alanine (b) and N,N-dimethylaminopropylamine (Dp) are typically used to form a C- terminal ...the hairpin polyamides and in certain cases results in increased affinity ...
9
Structural Variations on the Turn Unit of DNA Binding Hairpin Py Im Polyamides
... (S)-β-amino-γ-turn hairpin polyamides. Eight new polyamides targeting different DNA-binding motifs have been synthesized, and their impact on DNA duplex stabilization in relation to hairpins ...
209
One-to-one motif for DNA recognition by beta-alanine-linked polyamides
... that polyamides composed of five-membered heterocyclic amino acids contain insufficient structural information, when bound 1:1, to provide a general recognition ...
178
Thermal Behaviour and Fibre Studies of Certain New Aromatic – Aliphatic Polyamides
... azo polyamides are comparatively more rigid and less soluble in NMP / pyridine mixture, they are more easily precipitated and hence further growth is curtailed, resulting in a low molecular ...
10
Synthesis and Characterisation of Colorants Derived from 1,4 Diamino Anthraquinone Polyamides
... anthraquinone leads to the polyamides according to Scheme 1, pale to bluish purple precipitates are produced. The aromatic diamine has low basicity due to the delo- calization of the lone pairs on the amine groups ...
9
Spurious Response Suppression in Hairpin Filter Using CSRR Merged in the Filter Structure
... Then, we have added three CSRRs with radii of r = 2.4, 2.7, 2.9 mm to resonate at 4.5, 5 and 5.6 GHz respectively to the filter. We have also reduced the coupled section lengths about 7% to compensate the effect of ...
10
The Influence of Different Sterilization Techniques on the Time Dependent Behavior of Polyamides
... Time-dependent mechanical properties of testing samples were characterized by torsional creep measurements in non-sterilized state and after sterilization with three different techniques[r] ...
8
On hairpin vortices in a transitional boundary layer
... The transition from laminar to turbulent flow is of great practical interest. The final phase of laminar boundary layer transition starts always with the occurrence of first turbulent spots. Emmons [1] first reported the ...
8
Synthesis and Characterization of Novel Photoactive Poly(ether-amide)s Based on Highly Substituted Phenanthrimidazole
... of polyamides can be dramatically altered by minor variations in the structures of the diacid and diamine ...aromatic polyamides having improved solubility and processability with retention of their high ...
8
Investigation of Abrasive Wear Performances of Different Polyamides by Response Surface Methodology
... Response surface methodology (RSM) uses a statistical measure of performance to evaluate the optimal parameter settings. In the present work, three parameters such as load (L), speed (S) and tensile stress (T) on the ...
9
Synthesis and characterization of new polyamides derived from alanine and valine derivatives
... of polyamides based on benzene dicarboxylic acid, pyridine dicarboxylic acid, and α -amino acid linked to benzidine and 4,4 0 -oxydianiline to study the effect of the dicarboxylic acid as well as the amino acids ...
10
Preclinical Study of DNA-Recognized Peptide Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in Common Marmoset
... PI polyamides remained in the nuclei of the renal tubules on day 14, indicating that the “once a week” administration of PI polyamides may be effective for the treatment of progressive renal diseases ...PI ...
25
Synthesis and characterization of thermally stable aromatic polyamides and poly(1,3,4-oxadiazole-amide)s nanoparticles containing pendant substituted bezamides
... Our attention focused next on the synthesis of new types of aramide nanoparticles containing bulky pendent groups. Polymeric aromatic nanoparticles can be pre- pared by either emulsion or interfacial polymerizations. ...
17
Friction behaviour of hydrophilic lubricious coatings for medical device applications
... uncoated polyamides exhibited angles of 90° (PA33) and 101° (PA69), respectively, typical for hydrophobic surfaces, while unmodified chitosan (CH) exhibited contact angle of 34°, indicating its hydrophilic ...
15
Review on: Short Hairpin Ribonucleic Acid (RNA)
... RNA interference (RNAi), an accurate and potent gene silencing method, was first experimentally documented in 1998 in Caenorhabditis elegans by Fire et al. Subsequent RNAi studies have demonstrated that the clinical ...
10