Heat shock factor 1 (HSF1)
Molecular Stress-inducing Compounds Increase Osteoclast Formation in a Heat Shock Factor 1 Protein-dependent Manner
... activates heat shock factor 1 (Hsf1), the master transcriptional regulator of heat shock/cell stress responses, which may be involved in this negative action of 17-AAG ...
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Heat Shock Factor 1 Predicts Poor Prognosis of Gastric Cancer
... of HSF1 promotes proliferation, migration, and invasion of gastric cancer ...of HSF1 in AGS and MKN28 cells was achieved by transfection with an empty vector (pcDNA_EV) or HSF1 overexpression vector ...
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Tissue specific expression of zebrafish (Danio rerio) heat shock factor 1 mRNAs in response to heat stress
... of heat shock proteins (HSPs) is regulated at both transcriptional and post-transcriptional ...the heat shock transcription factor (HSF), which is present as an inactive form in ...
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Nitric oxide induces heat shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
... the heat shock ...the heat shock response (47, ...NO-induced HSF1 activation was completely blocked by DTT, a disulfide-reducing ...
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Thermal acclimation changes DNA binding activity of heat shock factor 1 (HSF1) in the goby Gillichthys mirabilis: implications for plasticity in the heat shock response in natural populations
... of heat stress, preventing their aggregation and degradation, and assisting in their eventual refolding (Fink, 1999; Hartl and Hayer-Hartl, ...with HSF1 (reviewed in Morimoto, 1998; Pirkkala et ...stress, ...
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Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages
... like heat shock, infections, radiation, and exposure to chemicals induce increased levels of heat shock proteins in many cell lines ...The heat shock pro- teins can be induced in ...
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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.
... We began by examining the role of the central pyrimidine ring. Introduction of a methyl group at C-5 to afford pyrimi- dine (5) was predicted to cause a steric clash with the other substituents on the ring, disfavouring ...
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Heat shock factor 1 protein in heat shock factor 1 gene transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein 70 production
... of HSF1 occurs in response to heat (37, 40–42) or inducers of transcriptional activation such as cad- mium and arachidonic acid (35, ...of HSF1 phosphorylation is thought to be associated with its ...
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Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
... ing HSF1 activation and hsp70 expression ...of HSF1 and hsp70 expression in synovial cells and thus may contribute to the overexpression of hsp70 observed in RA synovial ...of HSF1 and hsp70 seems to ...
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Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation
... of HSF1 occurs through post- translational modifications that allow this transcription factor to be released from HSP binding, move to the nucleus, bind DNA, and activate transcription from HSE-containing ...
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Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients
... of HSF1 was observed in a broad range of cancer cell lines and human tumors including colorec- tal cancer, breast cancer, lung cancer [9], hepatocellular carcinoma [10], endometrial carcinoma [11], oral squa- mous ...
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Heat shock factor 1, an inhibitor of non-homologous end joining repair
... [20–23]. HSF1 bound specifically to each of two components of DNA-PK (Ku70 and Ku86); however, HSF1 did not bind the catalytic subunit of DNA-PK (DNA-PKcs) (Figure ...that HSF1-mediated defective ...
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Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism
... with HSF1 for binding to DNA ...that heat shock, which increases the levels of HSF-1, has a suppressive effect on the inflammatory response, pos- sibly because HSF-1 exerts a ...
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Neurospora crassa heat shock factor 1 Is an Essential Gene; a Second Heat Shock Factor-Like Gene, hsf2, Is Required for Asexual Spore Formation
... Deleting hsf2 had a dramatic effect on asexual development; aerial hyphae developed but no conidial chains formed. The following six mutants blocked at different stages of conidial development have been placed in a ...
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Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients
... high HSF1 level was significantly correlated with multiple nodules, venous invasion, absence of capsular formation and high Edmondson-Steiner grade as well as poor outcome in HCC patients ...high HSF1 level ...
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Thermotolerant desert lizards characteristically differ in terms of heat shock system regulation
... and HSF1 in different lizard ...(lanes 1, 2, respectively) and after heat-shock treatment (h) for 1 h at 42 °C (lanes 3, 4, ...vivipara) HSF1 gene and Xenopus laevis HSP gene, ...
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Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii
... DICER-LIKE 1; DCL3: DICER-LIKE 3; CrDCL3: DCL3 of ...luciferase; HSF1: heat shock factor 1; HESO1: HEN1 suppressor 1; HEN1: HUA ENHANCER 1; HYL1/DRB1: HYPONASTIC ...
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The L-Type Cyclin CYL-1 and the Heat-Shock-Factor HSF-1 Are Required for Heat-Shock-Induced Protein Expression in Caenorhabditis elegans
... affected heat-shock-induced GOA-1 expression. The cyl-1 mutants are essentially wild type in appearance, while hsf-1 and sup-45 mutants have egg-laying ...expression. ...
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
... reactions were conducted in oven dried glassware under an atmosphere of nitrogen or argon using anhydrous solvents. All commercially obtained reagents and solvents were used as received. Thin layer chromatography (TLC) ...
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Interspecific and acclimation induced variation in levels of heat shock proteins 70 (hsp70) and 90 (hsp90) and heat shock transcription factor 1 (HSF1) in congeneric marine snails (genus Tegula): implications for regulation of hsp gene expression
... that HSF1 itself ‘senses’ thermal stress and may be an important type of ‘cellular ...which HSF1 is activated is not fixed (Abravaya et ...with HSF1 in a multi-protein complex under in vivo ...
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