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hedgehog signaling

Lipid metabolism fattens up hedgehog signaling

Lipid metabolism fattens up hedgehog signaling

... and hedgehog signal- ing ...in hedgehog signaling arguably remains the most puzzling aspect of hedgehog signal ...in hedgehog signaling is complex and ...

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Gastric cancer and Hedgehog signaling pathway: emerging new
paradigms

Gastric cancer and Hedgehog signaling pathway: emerging new paradigms

... The study did not meet the primary endpoint with a no significantly-improved progression-free survival between the placebo group and vismodegib group (9.3 months vs. 11.5; p = 0.34), although with a noticeable tendency ...

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Drugging Hedgehog: signaling the pathway to translation

Drugging Hedgehog: signaling the pathway to translation

... the Hedgehog signaling pathway ...the hedgehog (hh) gene that had originally been studied in ...Hh signaling could have applications in both regenerative medicine and cancer ...

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Roles of the Hedgehog Signaling Pathway in Skin Development, Homeostasis and Cancer

Roles of the Hedgehog Signaling Pathway in Skin Development, Homeostasis and Cancer

... Keywords: Hedgehog signaling; skin; epidermis; hair follicle; development; homeostasis; basal cell.. 20.[r] ...

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Hedgehog signaling is involved in development of the neocortex

Hedgehog signaling is involved in development of the neocortex

... Shh signaling controls stem cell behavior in adult brains (Machold et ...Shh signaling in initial patterning of the telencephalon have been analyzed by using Smoothened ( Smo ) conditional knockout mice ...

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C2cd3 is required for cilia formation and Hedgehog signaling in mouse

C2cd3 is required for cilia formation and Hedgehog signaling in mouse

... the Hedgehog signal. Furthering a link between Hedgehog signaling and cilia function, we find that cilia formation and proteolytic processing of Gli3 are disrupted in C2cd3 ...

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Role of canonical Hedgehog signaling pathway in liver

Role of canonical Hedgehog signaling pathway in liver

... Hh signaling in required for liver regeneration ...Hh signaling promotes transition of quiescent hepatic stellate cells to ...Hh signaling promotes progenitor cell accumulation ...

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Therapeutic potential of hedgehog signaling pathway agonist

Therapeutic potential of hedgehog signaling pathway agonist

... The Hedgehog (Hh) signaling pathway plays an integral role incorrect tissue patterning of a variety of different cell types during embryonic ...Hh signaling has potential therapeutic applications in ...

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Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue specific outputs of Hedgehog signaling

Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue specific outputs of Hedgehog signaling

... The visual primordium has anterior and posterior optic lobes (AOL and POL, respectively), and contains the precursor cells for Bolwig’s organ, the larval eye. During stage 11, the placode adopts a V-like shape and has ...

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Targeting hedgehog signaling in cancer: research and clinical developments

Targeting hedgehog signaling in cancer: research and clinical developments

... Hh signaling activation to a variety of human cancer implies the relevance of studying Hh signal- ing to human ...Hh signaling inhibitors has provided many opportu- nities for developing novel cancer ...

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Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

... Hh signaling pathway depend on intact cilia to modulate pathway ...Hh signaling requires intact ...Hh signaling using cyclopamine, a potent antagonist of ...Hh signaling in wild-type embryos, ...

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Regulation of ventral midbrain patterning by Hedgehog signaling

Regulation of ventral midbrain patterning by Hedgehog signaling

... HH signaling is possible (Bai et ...HH signaling in the retina and cerebellar granule cells regulates multiple aspects of proliferation and differentiation ...HH signaling cascade at which a given HH ...

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Temporal requirement for hedgehog signaling in ventral telencephalic patterning

Temporal requirement for hedgehog signaling in ventral telencephalic patterning

... Previous work from many labs has shown that Shh signaling is intimately linked with telencephalic oligodendrogenesis. The expression of early oligodendrocyte markers, such as Pdgfra and plp/dm20, is localized to ...

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Protein association changes in the Hedgehog signaling complex mediate differential signaling strength

Protein association changes in the Hedgehog signaling complex mediate differential signaling strength

... Hh signaling, allowing Fu catalytic activation, autophosphorylation and possibly dimerization (Ascano and Robbins, 2004; Robbins et ...Hh signaling in tissues in which Hh is active (Raisin et ...of ...

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Roles for Hedgehog signaling in adult organ homeostasis and repair

Roles for Hedgehog signaling in adult organ homeostasis and repair

... HH signaling in adult ...sonic hedgehog (SHH) to the subventricular zone (SVZ) neural stem cells (NSCs) and adjacent astrocytes (both depicted in ...

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Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies

Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies

... Hh signaling is required during hematopoiesis (Figure 2); however, its exact role is not completely understood and may differ depending on the stage of hematopoiesis, cell type (stem, primitive, or differentiated ...

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Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

... Hh signaling from Shh overexpressing cells, we next sought to investigate the arrest of Hh signaling from tumor ...Hh signaling in these cell lines occurred in a canonical manner, with inhibition in ...

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Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

... Fig. 5. Hh signaling is dispensable for survival of epithelial LRCs but is required for Hh-responsive stem cells to contribute to the ameloblast lineage. (A)  Time-course for treatment of K5tTA;H2B-GFP mice with ...

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The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway

The Design, Synthesis, and Biological Evaluation of Steroid-Derived Inhibitors of the Sonic Hedgehog Signaling Pathway

... Since the discovery of cyclopamine and the unveiling of the relevance to cancer biology, there have been a number of approaches taken by pharmaceutical companies to develop novel Sonic Hedgehog inhibitors. ...

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Hedgehog signaling drives medulloblastoma growth via CDK6

Hedgehog signaling drives medulloblastoma growth via CDK6

... Hh signaling itself were also upregulated, including Cdk6, the expression of which was 167 ± 42–fold higher than that in controls (Figure 1, A and ...Hh signaling during limb-bud development, (ii) ...

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