heme oxygenase-1
A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
... stress. Heme oxygenase-1 (HO-1) is a highly inducible, detoxifying enzyme critical for limiting oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and ...
327
Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine
... the heme from blood spilled into the sub- arachnoid space is metabolized by heme oxygenase (HO), generating excess free iron ...of heme oxygenase-1 (HO-1 or Hmox1) in DFX ...
15
Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats
... One important concern in the treatment of diabetes is the maintenance of glycemic levels and the prevention of diabetic nephropathy. Inducible heme oxygenase 1 (HO-1) is a rate-limiting enzyme ...
8
Biliary tract external drainage increases the expression levels of heme oxygenase-1 in rat livers
... Heme oxygenase-1 (HO-1) protects cells by anti-oxi- dation, maintaining normal microcirculation and anti- inflammatory under stress. Four decades of research have witnessed the HO-1 ...
6
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death
... biochemically, and genetically distinct from apoptosis, various forms of necrosis, and autophagy. This process is characterized by the overwhelming, iron-dependent accumulation of lethal lipid ROS [8]. Unlike other forms ...
11
Therapeutic potential of statins and the induction of heme oxygenase-1 in preeclampsia
... Factors that trigger the clinical signs of preeclampsia originate from the placenta. Confirmation of the presence of Hmox in the placenta is important to determine its role in preeclampsia. Indeed, over the last two ...
8
Heme oxygenase 1 deficiency accompanies neuropathogenesis of HIV associated neurocognitive disorders
... Two heme oxygenase isoforms (HO-1 and HO-2) are expressed to varying levels in nearly all cell lineages, but only HO-1, the rapidly inducible isoform, is considered to be a criti- cal mediator ...
15
ATF4 dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis
... particularly heme oxygenase 1 (HO-1), a rate-limiting enzyme that degrades heme to carbon monoxide (CO), biliverdin, and ferrous iron ...
18
Heme oxygenase 1 is a modulator of inflammation and vaso occlusion in transgenic sickle mice
... The heme content is elevated in sickle organs, which promotes vascular inflammation and heme oxygenase-1 ...increases heme oxygenase-1 expression and inhibits ...
10
Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase 1
... as Heme oxygenase-1 (HO-1) and superoxide dismutase 2 (SOD2) are an im- portant defense against ROS-mediated damage [6, ...degrading heme into ferrous iron, carbon monoxide and ...
11
Relationship of Heme Oxygenase-1 (HO-1) Level with Onset and Severity in Normotensive Pregnancy and Severe Preeclampsia
... of heme oxygenase-1 (HO-1) is at ...of heme-oxygenase-1 (HO-1) level is ...of heme oxygenase-1 (HO-1) level showed that p value: ...of ...
5
The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication
... infections. Heme oxygenase-1 (HO-1), an enzyme that catalyzes the rate-limiting step in heme degradation, has antioxidative properties and protects cells from various ...
8
Identification of heme oxygenase 1–specific regulatory CD8+ T cells in cancer patients
... Treg deficiencies are associated with autoimmunity. Conversely, CD4 + and CD8 + Tregs accumulate in the tumor microenvironment and are associated with prevention of antitumor immunity and anticancer immunotherapy. ...
13
The Status of Nitric Oxide and its Backup, Heme Oxygenase 1, in Thromboangiitis Obliterans
... SH. Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent ...RM. Heme oxygenase-1–derived carbon monoxide contributes to the suppression of acute ...
6
Inhibition of Heme Oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect
... by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperthermic therapy, for which the exact mechanism remains ...
11
Heme oxygenase-1: emerging target of cancer therapy
... Heme oxygenase-1 (HO-1) was initially identified as a liver microsomal protein with activity to degrade heme to bilirubin four decades ago ...kines, heme, hypoxia, nitric oxide, ...
7
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase 1 deficiency
... The first known human case of heme oxygenase-1 (HO-1) deficiency is presented in this report. The patient is a six-year-old boy with severe growth retardation. He has been suffering from ...
8
Inductive transcription and protective role of fish heme oxygenase 1 under hypoxic stress
... Heme oxygenase, the rate-limiting enzyme in heme catabolism, cleaves heme to form biliverdin IXa, carbon monoxide (CO) and iron (Tenhunen et ...the heme breakdown reaction (Kikuchi et ...
7
Heme oxygenase-1 regulates mitochondrial quality control in the heart
... 2. Heme oxygenase-1 overexpression protects cardiomyocytes from doxorubicin-mediated ...humanized heme oxygenase-1 (HO-1) overexpressing (HBAC) mice 14 days after ...
18
Heme oxygenase 1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats
... Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) causes cerebral ischemia and infarction. To date, the pathogenesis and gene expression associated with vasospasm remain poorly understood. The ...
9