Hepatic gene expression
Somatostatin is required for masculinization of growth hormone–regulated hepatic gene expression but not of somatic growth
... greater in males than in females, we generated knockout (Smst –/– ) mice to investigate whether SST peptides are necessary for sexually differentiated GH secretion and action. Despite marked increases in nadir and median ...
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Inhibition of PARP Activity Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice
... decreased hepatic gene expression of SREBP-1c, DGAT1 and DGAT2 in alcohol-fed ...attenuated hepatic TG accumulation in AFLD progression and the underlying mechanism is involved in ...
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Fatty Acid Composition, Lipogenic Enzyme Activities and Mrna Expression of Genes Involved in the Lipid Metabolism of Nile Tilapia Fed with Palm Oil
... and hepatic gene expression response of Nile tilapia fed diets with varying levels of dietary palm ...mRNA expression of lipid metabolism related genes in Nile tilapia fed diets with different ...
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Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice
... the expression of numerous hepatic genes encoding proteins that are involved in lipid metabolism and inflam- mation at an early-onset stage of ...of hepatic gene expression may explain ...
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Modulation of hepatic PPAR expression during Ft LVS LPS induced protection from Francisella tularensis LVS infection
... of gene- expression changes after infection with Ft ...in hepatic gene expression after 48 hours of treatment in uninfected ...using gene set enrichment analysis (GSEA) we showed ...
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Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats
... We recently performed a sub-chronic (6-week) feeding study examining the effects of an antioxidant supple- ment on markers of liver health during concomitant WD feeding in 9-month old adult Brown-Norway rats [10]. When ...
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The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
... Inc.), hepatic stel- late cells by desmin staining (using Thermo Scientific Lab Vision anti– desmin RB-9014-P antibody), macrophages (using clone CI:A3-1 from AbD Serotec for F4/80 or pan-macrophage antibody ...
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Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver
... the gene expression profile of T1DM ...in gene expression in the liver are caused by diabetes-induced ...genomic expression patterns in mouse ...
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Alterations in the gene expression of drug and arachidonic acid-metabolizing Cyp450 in the livers of controlled and uncontrolled insulin-dependent diabetic mice
... The gene expression of 14 genes, which play a major role in drug and arachidonic acid metabolism, were measured using quantitative real-time polymerase chain reaction ...the gene expression ...
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Epigenetic Alterations of Hepatic IGF-II Gene Promoter and IGF-II Abnormal Expression in HBV-Related Hepatocellular Carcinoma
... The resulting cDNA was amplified by a nested PCR with two pairs of primers. The oligonucleotides were designed according to IGF- II sequence and synthesized with synthesizer (Model 381A, Applied Biosystems, Foster City, ...
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The HMGB1/RAGE axis triggers neutrophil mediated injury amplification following necrosis
... partial hepatic isch- emia as previously described ...the hepatic artery, portal vein, and bile duct were occluded using a microvascular clamp (Fine Science Tools) proximally to caudate hepatic ...
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Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice A novel mechanism signals changes in plasma cholesterol levels
... of hepatic CETP mRNA revealed a sevenfold increase in chow-fed NFR- CETP Tg/E0 mice compared to NFR-CETP Tg controls and an eightfold increase on the high cholesterol diet ...shown). Hepatic CETP mRNA ...
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Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma
... Interestingly, hepatic stellate cells (HSCs), myofibroblast- like inflammatory cells under activated state, display plas- tic phenotypes and properties of progenitor cells ...tional gene in HSCs, enhanced ...
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Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and Hdac3
... and hepatic triglyceride content was nearly double that of WT mice (Figure ...modest hepatic steatosis in the Rev-erb deficient mice likely reflects a role for HDAC3 in mediating effects of other NRs, ...
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Adenosine triphosphate dependent copper transport in isolated rat liver plasma membranes
... The hepatic expression of the Wilson disease gene encoding for a P-type ATPase 9, together with the presently demonstrated ATP-dependent Cu transport in rat plasma membrane preparations,[r] ...
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Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver
... adenovirus gene therapy and that TRAIL serves as an impor- tant regulator of a positive-feedback loop for further NK cell activation and cytokine production by other cells in the ...longed gene therapy ...
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Feeding oxidized fat during pregnancy up-regulates expression of PPARα-responsive genes in the liver of rat fetuses
... on gene expression of lipogenic enzymes in fetal livers indicating that the reduced hepatic triacylglycerol concentrations in fetuses from pregnant rats treated with oxidized fat are probably largely ...
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Expression of Hepatic Cytochrome P450 Drug Metabolizing Enzymes in Diabetes and Diabetic Nephropathy
... The STZ-induced model of rodent diabetes is widely used for its ease of use, cost effectiveness, and relatively straightforward generation of hyperglycemia. Since other diabetic mouse models often involve costly genetic ...
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Stemness-Related Transcriptional Factors and Homing Gene Expression Profiles in Hepatic Differentiation and Cancer
... elevated expression in multiple cancers, con- tributing to their aggressiveness and bad outcome ...relative expression of these transcripts and their significant clinical associations in HCV-induced ...
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Farnesoid X receptor represses hepatic human APOA gene expression
... SHP expression plasmid showed that SHP did not repress and instead increased the APOA promoter activity in HepG2 as well as in COS-7 cells (Supplemental Figure ...
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