Hereditary leiomyomatosis and renal cell cancer
Hereditary leiomyomatosis and renal cell carcinoma
... Abstract: Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal-dom- inant hereditary syndrome, which is caused by germline mutations in the FH gene that encodes ...
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Long-term response of metastatic hereditary leiomyomatosis and renal cell carcinoma syndrome associated renal cell carcinoma to bevacizumab plus erlotinib after temsirolimus and axitinib treatment failures
... Trials on temsirolimus and VEGFR TKIs were con- ducted on a mixture of nccRCC variants, which included sarcomatoid, papillary type 1, papillary type 2, chromo- phobe, unclassified, and MiT family translocation RCC. ...
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What is new in Genitourinary Pathology? Recent developments and highlights of the new 2016 World Health Organization classification of tumors of the urinary system and male genital organs
... Hereditary leiomyomatosis and renal cancer syndrome (HLRCC) is an autosomal dominant disorder characterized by inherited predisposition to uterine and cutaneous leio- myomas and renal ...
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Staged, Open, No-Ischemia Nephron-Sparing Surgery for Bilateral-Multiple Kidney Tumors in a Patient with Birt-Hogg-Dubé Syndrome
... cited. Hereditary kidney cancer patients with bilateral multiple kidney tumors represent challenges in the era of rapidly growing minimal invasive treatment ...malignant renal tumors and pulmonary ...
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Synthesis and In Vitro Antiproliferative Activity of New -Phenyl-3-(4-(Pyridin-3-Yl)Phenyl)Urea-Scaffold Based Compounds
... against different cell lines of different cancer types; leukemia, colon, renal cancer and breast cancer. 151[r] ...
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Original Article Leiomyomatosis peritonealis disseminata coexisting with endometriosis within the same lesions: a case report with review of the literature
... Abstract: Leiomyomatosis peritonealis disseminata (LPD) is an extremely rare condition, which is characterized by the presence of multiple peritoneal and subperitoneal nodules composed of bland smooth muscle ...
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Familial risks of second primary cancers and mortality in ovarian cancer patients
... breast cancer and the rest were other individual ...Pancreatic cancer, leukemia (seven acute myeloid leukemia, three acute mono- cytic leukemia, and one megakaryocytic type), liver, and lung cancers were ...
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Original Article Down-regulation of miR-497 is associated with poor prognosis in renal cancer
... Clear cell renal cell carcinoma (ccRCC) is the most common type of cancer in the adult kid- ney, and the prognosis of metastatic ccRCC remains poor with high ...in renal cancer ...
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HEREDITARY RENAL DYSFUNCTION AND DEAFNESS
... tion of the syndrome; normal hearing in al- most half our patients with renal disease. emphasizes this fact[r] ...
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The genetic basis of Lynch syndrome and its implications for clinical practice and risk management
... colorectal cancer syndrome to be well characterized was called familial adenomatous polyposis (FAP) and was characterized by very early onset, massively prolific develop- ment of colorectal ...colorectal ...
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Population screening for hereditary and familial cancer syndromes in Valka district of Latvia
... tary cancer is careful analysis of the family cancer his- tory and search for mutations in a patient receiving tumour treatment ...own cancer risk and undergo appropriate diagnostic ...detect ...
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Identification of biomarkers of chromophobe renal cell carcinoma by weighted gene co-expression network analysis
... Results: Overall 2215 DEGs were screened out to construct eight co-expression modules. Brown module was identi- fied as the key module for the highest correlations with pathologic stage, neoplasm status and survival ...
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Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer
... Colorectal cancer (CRC) associated with hereditary nonpolyposis colorectal cancer (HNPCC) accounts for 3 % of newly diagnosed cases. It is genetically driven by an autosomal dominant mutation of DNA ...
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LncRNA GAS5 contributes to lymphatic metastasis in colorectal cancer
... breast cancer samples relative to adjacent unaffected normal breast epithelial tissues, could controls apoptosis and down-regulated in breast cancer ...T-lymphocytes, renal cell carcinoma, ...
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Occupational Sunlight Exposure and Risk of Renal Cell Carcinoma
... Interviewers were trained in each center to perform face-to-face interviews with cases and controls during hospitalization using standard questionnaires. The questionnaire covered basic demographic characteristics, ...
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Sunitinib for advanced renal cell cancer
... of cancer drug therapy to the patient must be described in terms of the incremental gain in the quantity or quality of life at acceptable risk, toxicity and economic cost, when comparing standard and novel treat- ...
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GOLPH2 expression in renal cell cancer
... chromosome 9q21.33, first described by Kladney et al. in liver tissue of a patient with giant-cell hepatitis [2]. Struc- turally, GOLPH2 protein has of a short cytoplasmic N-ter- minal domain, a membrane-spanning ...
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The Gene Master Regulators (GMR) Approach Provides Legitimate Targets for Personalized, Time-Sensitive Cancer Gene Therapy
... tissue in a case of metastatic clear cell renal cell carcinoma, a case of papillary thyroid cancer and two 356. cases of prostate cancer[r] ...
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Experience of Sorafenib as First-Line Treatment in Metastatic Renal Cell Carcinoma in a Tertiary Care Centre
... The Median age was 55 years. Male to female ratio was 1.73:1. Most of patients in this study have ECOG performance status 2 (51.67%). Most common sites of metastasis were lung (66.67%) followed by bone (36.67%) and liver ...
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Original Article Up-regulation of Tim-3 is associated with poor prognosis of patients with colon cancer
... 3% hydrogen peroxide for 15 minutes at room temperature. Then rinsed the slides in 0.01 mol/L phosphate-buffered saline solution (PB- S) for (3 × 5 min). Following incubation with the primary mouse polyclonal antibody ...
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