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hexosamine biosynthetic pathway

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway

... and hexosamine metabolites in the UOK262 cells and to a much lesser extent in the UOK262WT cells, indicating an activation of the hexosamine biosynthetic pathway (HBP) by ...

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Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

... cell pathway or cancer-specific stem cell pathways; thus, more studies are warranted to understanding mo- lecular links between the HBP and cancer stem cell ...

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In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

... To test the hypothesis that increased flux through the hexosamine biosynthetic pathway can induce insulin resistance in skeletal muscle in vivo, we monitored glucose uptake, glycolysis, [r] ...

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Role of the glucosamine pathway in fat induced insulin resistance

Role of the glucosamine pathway in fat induced insulin resistance

... the hexosamine pathway (18, ...glucosamine pathway as the po- tential mechanism by which hyperglycemia could induce resis- tance to insulin ...the hexosamine biosynthetic ...

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Effects of hypoglycemia on myocardial susceptibility to ischemia–reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes

Effects of hypoglycemia on myocardial susceptibility to ischemia–reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes

... AAR: area at risk; ANOVA: analysis of variance; DM: diabetes mellitus; HBP: hexosamine biosynthetic pathway; IPC: ischemic preconditioning; IR: ischemia reperfusion; IS: area of infarc[r] ...

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A unique Tryptophan C prenyltransferase from the kawaguchipeptin biosynthetic pathway

A unique Tryptophan C prenyltransferase from the kawaguchipeptin biosynthetic pathway

... kawaguchipeptin biosynthetic gene cluster in plasmid pMQ123i was co-introduced with plasmid pMBI (Martin 2003) into ...kawaguchipeptin biosynthetic gene cluster was grown overnight in LB media with ...

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Elucidation of the prodiginine biosynthetic pathway in Streptomyces coelicolor A3(2)

Elucidation of the prodiginine biosynthetic pathway in Streptomyces coelicolor A3(2)

... of biosynthetic precursors), which are condensed to form the common 4,5-dimethyl-3-oxo-2-methylene cyclopentane carboxylic acid core of 5 and 6 (Corre and Challis, ...

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Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

... for engineered NRPS systems. This finding suggests hybrid enzyme complexes were more flexible and diverse in terms of biosynthetic potential than envisaged based on their design. This makes it difficult to design ...

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Enzymes of the Heme Biosynthetic Pathway in the Nonphotosynthetic Alga Polytomella sp.

Enzymes of the Heme Biosynthetic Pathway in the Nonphotosynthetic Alga Polytomella sp.

... heme biosynthetic enzymes all exhibit predicted long N-terminal extensions relative to their prokaryotic counterparts, and these extensions likely serve as targeting ...

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Engineering of a microbial coculture of Escherichia coli strains for the biosynthesis of resveratrol

Engineering of a microbial coculture of Escherichia coli strains for the biosynthesis of resveratrol

... As an initial step to generate a bacterial platform for the biosynthesis of resveratrol, we first built a plasmid for expressing the genes coding for the last two enzymes required by the biosynthetic ...

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How genes paint flowers and seeds

How genes paint flowers and seeds

... flavonoid biosynthetic pathway produce pigmentation in flower (Mol et ...phenylpropanoid pathway with aromatic amino acid phenylalanine as the basic ...flavonoid biosynthetic genes or ...

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Effect of Acute Clinical Stress on the Levels of Hexosamine in Serum and Its Excretion in Urine

Effect of Acute Clinical Stress on the Levels of Hexosamine in Serum and Its Excretion in Urine

... The increase in serum hexosamine levels and in the urinary excretion of hexosamine following acute diseases or injury does not appear to be mediated by the adrenal cortex for the followi[r] ...

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Homoserine Toxicity in Saccharomyces cerevisiae and Candida albicans Homoserine Kinase (thr1Δ) Mutants

Homoserine Toxicity in Saccharomyces cerevisiae and Candida albicans Homoserine Kinase (thr1Δ) Mutants

... of pathway flux on thr1 ⌬ ...thetic pathway flux should increase homoserine accumulation and consequently exacerbate the deleterious phenotypes of thr1 ⌬ ...threonine pathway genes via the general ...

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Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast

Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast

... Plasmid pZ_BCGN was linearized, transferred into the wild-type strain, and employed to screen the microbes for DML-overproducing strains. As shown in Fig. 2a, b, strain P. p/DML_D#9 grown at 2.0 mg/mL Zeocin produced the ...

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Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation

Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation

... the biosynthetic pathway needs to be maintained for proper iNKT cell development, proliferation and ...this pathway, or in- fluence the specific identity of antigens that are being presented, may ...

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3.	Hui Zeng, Li Yang, Hua Rong, Weiwei Zhang, Feng Xu and Xin Zhang

3. Hui Zeng, Li Yang, Hua Rong, Weiwei Zhang, Feng Xu and Xin Zhang

... biloba , function analysis indicated that GbFLS is a bifunctional enzyme within the flavonol biosynthetic pathway, recombinant GbFLS1 protein could... In the current stud[r] ...

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Investigations related to branched chain amino acid metabolism

Investigations related to branched chain amino acid metabolism

... Detailed information about acetohydroxyacid synthase, the first enzyme of the valine-isoleucine biosynthetic pathway has come from work on bacterial enzymes. Studies have shown that the L-amino acids ...

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Stereochemistry and biosynthesis of (+)-lyoniresinol, a syringyl tetrahydronaphthalene lignan in Lyonia ovalifolia var. elliptica II: feeding experiments with 14C labeled precursors

Stereochemistry and biosynthesis of (+)-lyoniresinol, a syringyl tetrahydronaphthalene lignan in Lyonia ovalifolia var. elliptica II: feeding experiments with 14C labeled precursors

... C]lignans in the feeding experiments, the biosynthetic pathway outlined in Fig. 1 is proposed. Nonselective cou- pling of SA gives both (8R,8′R)-(+)-SYR and (8S,8′S)- (−)-SYR, which are reduced with low ...

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Discovery of the Elusive UDP Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis

Discovery of the Elusive UDP Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis

... Like other Gram-negative bacteria, C. trachomatis has a dual- membrane cell envelope. Its outer leaflet is composed of lipooli- gosaccharide (LOS) that displays a short, branching core of three 3-deoxy- D ...

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Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway

Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway

... dogenous hexosamine pathway was inhibited and the expression of apoM was suppressed ...the hexosamine path- way was continued by exogenous substrate and apoM mRNA was increased ...

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