high mobility group B-1
Bench to bedside review: High mobility group box 1 and critical illness
... targeting high-mobility group box 1 As yet, of course, no anti-HMGB1 therapeutic is available for clinical administration to ...polymyxin B [106,107], can indirectly decrease ...
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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... 3.2). 1 H- 15 N HSQC spectra were collected for the 15 N-labelled Δ30, A box, B box and IL-1β ...and B box NMR spectra and no significant chemical shift perturbations were observed following ...
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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
... and B) and a natively charged C tail (for transcription stimulation) domain (Figure ...and B boxes are about 75–80 amino acids long and are formed by two short and one long a-helix that, upon folding, ...
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Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells
... passages 1 and 2 were dissociated as ...Millipore, 1:500) to identify neurons, with mouse anti- GFAP (Sigma, 1:1,000) to identify astrocytes, and anti-CNP (Sigma C5922 1:100) to identify ...
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Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
... HMGB1 (previously also called HMG1, amphoterin and p30) is a nonhistone DNA binding protein that is abundant in the cell nucleus. Nuclear HMGB1 acts as a DNA chaperone with DNA binding and bending activities and ...
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Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus
... box, B box and acidic ...and B box are important for its DNA binding functions and are positively charged, whereas the tail is negatively charged, giving the molecule a bipolar ...
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High mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
... binding B box domain mediates the proinflammatory effects of HMGB1, while the DNA-binding A box is an anti- inflammatory molecule that inhibits these activities mediated by full-length HMGB1 protein ...
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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis
... Methods: Thirty-five patients with active LN were included. Renal biopsies were performed at baseline and after standard induction therapy; corticosteroids combined with immunosuppressive drugs. The biopsies were ...
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Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis
... HMGB1 is a multifunctional factor that is functionally influenced by its subcellular location. It mainly exists in eukaryotic chromosomes in the cell nucleus, where it acts as a DNA chaperone to bind to minor grooves of ...
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Renal Expression and Clinical Significance of High Mobility Group Box 1 in Lupus Nephritis
... of high mobility group box 1 (HMGB1) expression in nephridial tissues of lupus nephritis ...assessment group (BILAG) ...had high renal disease activity (BILAG ...
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High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis
... HMGB1 (previously designated HMG1 or amphoterin) [12] is not a new protein. It was discovered > 30 years ago as a nuclear DNA-binding protein and was initially named for its characteristic rapid electrophoretic mobi- ...
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High mobility group box-1 and its clinical value in breast cancer
... cell lines (Hs5787 and MDA-MB-231) than in less aggressive MCF-7 cells. Decreasing HMGB1 proteins using an antisense ribozyme approach inhibited transformation in human breast cancer cells. In contrast, increased ...
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Serum High Mobility Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections
... and B viruses in outpatient settings (39). Substantial influenza B virus infections were noted among pediatric influenza-associated fatalities (40), and it has been suggested that oseltamivir may be less ...
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High mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice
... Essential roles of HMGB1 in early loss of transplanted islets. (A) Nonfasting plasma glucose levels in STZ-induced diabetic mice received 200 syngeneic islets (top panel) and those treated with chicken anti-HMGB1 ...
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The Role of High Mobility Group Box 1 in Innate Immunity
... (1--79), B box (89-- 162), and the acidic C tail ...the B box do- main plays an important role in DNA binding and stimulating proinflammatory ...The B box domain consists of two crucial bind- ...
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High Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater
... Table 1. High expression of HMGB1 was confirmed in 31 (39%) ...grade B or C postoperative pancreatic fistula, defined by the Inter- national Study Group of Pancreatic Fistula classification ...
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Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)
... High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine ...κ B translocation and tumor necrosis factor (TNF) production in ...thiol group ...
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Overexpression of high mobility group box 1 contributes to progressive clinicopathological features and poor prognosis of human bladder urothelial carcinoma
... IHC, high HMGB1 expression was examined in 84 of 165 (51.0%) BUC cases. High HMGB1 expression was significantly correlated with poorer differentiation and higher T and N classifica- tion (all ...that ...
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Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... The high mobility group box-1 protein (HMGB1) is an inflammatory marker which has been shown to play a role in inducing and influencing ...
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Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes
... Because methamphetamine up-regulated the expression of HMGB1 and activated the Src/ERK/NF-κB p65 pathway, we next investigated the link between HMGB1 expression and the Src/ERK/NF-κB p65 pathway. We pretreated C6 cells ...
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