High mobility group protein
The High Mobility Group Protein 1 Is a Coactivator of Herpes Simplex Virus ICP4 In Vitro
... ICP4 is an activator of herpes simplex virus early and late gene transcription during infection and in vitro can efficiently activate the transcription of a core promoter template containing only a TATA box and an ...
6
Original Article High mobility group protein B1 (HMGB1) increased in kidney tissues of patients with lupus nephritis
... Abstract: High mobility group protein B1 (HMGB1) is both a nuclear and cytosolic protein that is increasingly recog- nized as an important pro-inflammatory mediator, actively secreted ...
7
The high mobility group protein HMO1 functions as a linker histone in yeast
... the protein with greatest sequence similarity to H1 is ...yeast high mobility group (HMGB) protein HMO1 has been reported to compact chromatin, as evidenced by increased nuclease ...
12
High mobility group protein B1 is a predictor of poor survival in ovarian cancer
... This finding was expanded on in a validation cohort of 360 ovarian cancer cases with extensive clinical data. Of the 321 evaluable ovarian tumours stained with the HMGB1 specific monoclonal antibody, 43/321 (13%) had ...
9
Real-time monitoring of PtaHMGB activity in poplar transactivation assays
... a high mobility group protein in poplar, which can activate the PtaLHY2 promoter in a gate‑dependent ...PtaHMGB2/3 protein regulation along the ...
15
Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells
... as high mobility group protein A2 (HMGA2) [11], which is a member of the HMG super- family of non-histone proteins found in the nuclei of mammalian cells that bind to nucleosomes and the minor ...
11
HMGA2 expression in white adipose tissue linking cellular senescence with diabetes
... A protein that is apparently linked to the process of proliferation and differentiation of adipose tissue stem and progenitor cells is high mobility group protein AT-hook 2 ...
8
High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis
... anorexia, and weight loss, as well as cytokine production in the brain, acute lung injury and production of pro- inflammatory cytokines/mediators in the lungs, promo- tion of translocation in the gut, induction of ...
6
High Mobility Group Box Protein-1 Correlates with Renal Function in Chronic Kidney Disease (CKD)
... part, explain the elevated circulating lev- els in CKD patients. It also can be as- sumed that current standard dialysis methods would remove only a small fraction of the circulating protein. How- ever, not only ...
7
High Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater
... of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as cell proliferation, inflammation, and the immune response, has been reported to be ...
8
Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... in protein loading buffer with 4% SDS, boiled for 5 min and resolved by 2–12% gradient SDS-PAGE and transferred to a nitrocellulose membrane for subsequent probing with monoclonal antibodies against HMGB1 and ...
11
Potential Role for a β-Catenin Coactivator (High-Mobility Group AT–Hook 1 Protein) during the Latency-Reactivation Cycle of Bovine Herpesvirus 1
... coactivator, high- mobility group AT– hook 1 protein (HMGA1), was detected in significantly more neu- rons in the trigeminal ganglia of latently infected calves than in those of uninfected ...5 ...
15
The N terminal domain of thrombomodulin sequesters high mobility group B1 protein, a novel antiinflammatory mechanism
... A quantitative assay for assessing the ability of TM-derived peptides to block HMGB1-sRAGE interaction was developed as follows. A 96-well plate with aldehyde-activated amine-conjugated plastic (Sumitomo Inc.) was used ...
9
Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus
... rocytosis (37). RAGE-deficient macro- phages were shown to have a dimin- ished capacity to phagocytose, and the inhibitory effect of HMGB1 on phagocy- tosis was contributed to the C-terminal tail of the protein. ...
8
Inflammasomes: Pandora’s box for sepsis
... of high-mobility group box 1 protein (HMGB1), microparticles (consisting of IL-1β, NLRP3, ASC, and CASP1) binding to endothelial cells and stimulating the induction of higher expression of ...
26
The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear deoxyribonucleic acid (DNA)-bind- ing protein, was recently rediscovered as a new potent pro-inflammatory cytokine when ...
7
High mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
... HMGB1 protein [67]. In a study of CIA, systemic administration of A box protein reduced mean arthritis score, disease-induced weight loss, and histologic severity [50] in mice and ...box protein ...
10
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
... duced HMGB1, which expresses three cysteine thiol residues, exerts chemotactic activity by forming a hetero-complex with CXCL12, which binds to the CXCL12-re- ciprocal receptor CXCR4 and initiates chemotaxis in a ...
7
Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
... binding protein that is abundant in the cell ...25-kDa protein containing two positively charged DNA-binding do- mains (HMG box A and B) and a nega- tively charged ...
10
Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... ASD. In 2010, Emanuele et al. (58) firstly suggested that HMGB1 can play a role in ASD. They observed higher HMGB1 blood concentrations in a sample of young adults with ASD than in healthy age- and gender- matched ...
8