Highly and Poorly Water Soluble Drugs.
Development and Optimization of Osmotically Controlled Oral Drug Delivery Systems for Highly and Poorly Water Soluble Drugs
... FOR HIGHLY AND POORLY WATER SOLUBLE DRUGS ” and that neither any part of this thesis nor the whole of the thesis has been submitted for a degree to any other University or ...
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CONTROLLED DRUG RELEASE FOR POORLY WATER SOLUBLE DRUGS A ROLE OF POLYMERIC NANOPARTICLES
... encapsulate drugs and release them at sustained rates in the optimal range of drug concentration, thus enhancing the in vivo therapeutic efficacy, maximizing patient compliance, and facilitating the use of ...
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Polymeric precipitation Inhibitors to improve the dissolution and absorption of poorly water soluble drugs
... basic drugs such as ketoconazole, dipyridamole, and carvedilol, easily dissolve in gastric pH and then may occur the precipitation or reach the supersaturation entering the duodenum due to higher environmental ...
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Nanosuspension: An emerging trend to improve solubility of poorly water soluble drugs
... 3. Nanosuspension for topical/dermal drug delivery Dermal nanosuspensions are mainly of interest if conventional formulation approaches fail.The nanocrystalline form leads to an increased saturation solubility of the ...
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Chemical Modification: A unique solutions to Solubility problem
... of water and one or more water miscible solvents used to create a solution with enhanced solubility for poorly soluble ...of poorly soluble drugs can be administered ...
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A review on bio-availability enhancement techniques of poorly soluble drug
... highly dependent on the physicochemical properties of the compounds and their miscibility in the molten state. There is a potential that the API, the polymer or both may degrade if excessively high temperature is ...
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Journal of Applied Pharmaceutical Science
... co-processing. Highly water soluble Metoprolol succinate and poorly water soluble anhydrous Theophylline was used as model drugs for Invitro release ...
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NANOSUSPENSION TECHNOLOGY FOR POORLY SOLUBLE DRUGS: AN OVERVIEW
... hole homogenizer particle size decrease is depends on the cavitation rule. Particles are additionally diminished by because of high shear power and a Collision of the particles against one another. The dispersion ...
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NOVEL PHARMACEUTICAL APPLICATION OF MIXED SOLVENCY IN THE FORMULATION DEVELOPMENT OF SYRUPS (LIQUID ORAL SOLUTIONS) OF POORLY WATER-SOLUBLE DRUGS
... Hydrotropes 1-15 and co-solvents have been observed to enhance the aqueous solubilities of poorly soluble drugs. Solubility is defined in quantitative terms as the concentration of the solute in a ...
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Volume 4 | Issue 1 - 2014
... Another highly investigated system is dextran-cholic acid. Cholic acid is one of the major bile acids that help to deliver and digest hydrophobic fats in the human small intestine via bile acid self-aggregates. ...
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Volume 3 | Issue 4 - 2013
... in water solubility of sparingly soluble ...of water insoluble ...are highly water soluble called as “hydrotropic salts” and a phenomenon known as ...hydrophobic drugs, ...
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DEVELOPMENT OF DISINTEGRATION CONTROL MATRIX TABLETS OF FEBUXOSTAT
... of water in the matrix which is the rate determining step for dissolution of the ...contains water soluble matrix forming polymer HPMC, disintegrating agent sodium alginate, and carnauba wax which is ...
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Effect of biocompatible polymers on the physicochemical properties of fenofibrate in nanoparticle system
... were soluble in ethanol. PVP is cationic, hydrophilic and soluble in water (Oh et ...and soluble in water (Lim et ...and water-swellable(Kang et ...in water (Hernandez et ...
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Preparation, solid state characterization and evaluation of ketoprofen-glucosamine HCl solid dispersions
... of poorly water-soluble drugs, using solid dispersions: eutectic formation, formation of true solid solution, reduction of particle size to submicron or molecular size ...some drugs ...
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Preparation and Evaluation of The Novel Drugdrug Solid Dispersion of Atorvastatin Calcium and Losartan Potassium.
... a water-soluble carrier and heating it directly until it ...either drugs or carriers, may decompose or evaporates during the fusion process which employs high ...
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“SOLUBILITY ENHANCEMENT TECHNIQUES” by Varun Raj Vemula*, Venkateshwarlu Lagishetty, Srikanth Lingala, India.
... in water, they are known to exhibit influences on surfactant aggregation leading to micelle formation, phase manifestation of multicomponent systems with reference to nanodispersions and conductance percolation, ...
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“NANOSUSPENSION - A NEW APPROACH OF BIOAVAILABILITY ENHANCEMENT” by Kalpesh S. Wagh*, Satish K. Patil, , Anup K. Akarte, Dheeraj T. Baviskar, India.
... Novel nanosizing and solubilization technology whose application has increased particle size reduction via supercritical fluid (SCF) processes. A supercritical fluid (SF) can be defined as a dense non condensable fluid. ...
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“Development and Evaluation of Asymmetric Membrane Capsules of Indomethacin: New Prospect in Osmotic Drug Delivery” by Rajwinder Kaur, Arun Gupta, Rupinder Kaur, Jasmine Kaur Bhatia, India.
... The higher percent released from the AMC containing glycerol is due to its high porosity causing higher influx of dissolution medium resulting in quick build-up of osmotic pressure inside the system. Osmogents had ...
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CURRENT TRENDS IN SOLID DISPERSION: A REVIEW
... The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. The matrix can be either crystalline or amorphous. The ...
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Volume 2 | Issue 1 - 2012
... of poorly water soluble drugs in presence of the ...of poorly of poorly water soluble drugs with ...
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