Highly water soluble drugs
Development and Optimization of Osmotically Controlled Oral Drug Delivery Systems for Highly and Poorly Water Soluble Drugs
... 44 strength and elasticity of the film. Here the film of cellulose acetate with plasticizer was evaluated. The free films were prepared by film casting method (8.5 ml in a petri dish of diameter 7.3 cm). The cellulose ...
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“Novel STRATEGIES FOR poorly water soluble drugs” by Bindu MB*, Kusum B and David Banji, India.
... poor water soluble drug dissolution is rate limiting step in the process of drug ...poorly soluble compounds as Class III and IV drugs, compounds which feature poor solubility and high ...
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FORMULATION AND EVALUATION OF SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM CONTAINING POORLY WATER SOLUBLE ANTILIPIDEMIC DRUGS
... physico-chemical parameters such as globule size, zeta potential, polydispersity index, drug release profile and physico-chemical stability. The composition of optimized formulation consisted of Capmul MCM Oil as oil ...
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MODULATION OF DRUG RELEASE KINETICS OF A HIGHLY WATER SOLUBLE DRUG FROM HYDROPHILICMATRICES
... Venlafaxine is a novel antidepressant having relatively short elimination half-life necessitating its administration, two or three times daily so as to maintain adequate plasma levels of drug. However, the high aqueous ...
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CONTROLLED DRUG RELEASE FOR POORLY WATER SOLUBLE DRUGS A ROLE OF POLYMERIC NANOPARTICLES
... encapsulate drugs and release them at sustained rates in the optimal range of drug concentration, thus enhancing the in vivo therapeutic efficacy, maximizing patient compliance, and facilitating the use of ...
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Polymeric precipitation Inhibitors to improve the dissolution and absorption of poorly water soluble drugs
... basic drugs such as ketoconazole, dipyridamole, and carvedilol, easily dissolve in gastric pH and then may occur the precipitation or reach the supersaturation entering the duodenum due to higher environmental ...
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MODIFIED NATURAL CARRIER IN SOLID DISPERSION FOR ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUGS
... is highly soluble in ...and water retention capacity of modified gaur gum was not reduced significantly rather than that of the gaur ...enhanced. Water retention capacity of carrier is the ...
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Nanosuspension: An emerging trend to improve solubility of poorly water soluble drugs
... 3. Nanosuspension for topical/dermal drug delivery Dermal nanosuspensions are mainly of interest if conventional formulation approaches fail.The nanocrystalline form leads to an increased saturation solubility of the ...
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LIQUISOLID COMPACTS OF CLOFIBRATE: AN APPROACH TO ENHANCE THE DISSOLUTION AND BIOAVILABILITY OF POORLY WATER SOLUBLE DRUGS
... solution or drug suspension of desired concentration. Next a certain amount of the prepared drug solution or suspension, or the liquid drug itself incorporated into a specific quantity of carrier material which should be ...
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Enhancement of the Solubility of Poorly Water Soluble Drugs through Solid Dispersion: A Comprehensive Review
... poorly soluble drugs. Formulation of poorly soluble drugs as solid dispersions offer a variety of processing and excipient options that enhances the operational flexibility when formulating ...
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Amorphous solid dispersion: a promising technique for improving oral bioavailability of poorly water-soluble drugs
... is highly temperature-dependent, it is crucial to adjust the temperature, so that when the melt of the drug carrier mixture is dropped onto the plate it solidifies to a spherical ...
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Cubic liquid crystalline nanoparticles (cubosomes) to improve solubility and bioavailability of poorly water soluble drugs: A review
... This method involves the mixing of lipid with stabilizer to form a homogenized solution. The resultant solution is then dispersed into the aqueous medium under high-pressure homogenization or sonication eventually to ...
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Solid Dispersion as Strategy to Improve the Solubility of Poorly Water Soluble Drugs and their Utilization and Consideration during Formulation Development
... of drugs under specified ...be highly soluble when its highest clinical dose strength is soluble in <250 ml of aqueous media at pH range 1- ...
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Gastrointestinal lipolysis of lipid-based excipients intended for the oral drug delivery of poorly water-soluble drugs
... Abstract: Labrasol ® and Gelucire ® 44/14 are lipid-based excipients used for the oral drug delivery of poorly water-soluble drugs. These macrogolglycerides are composed of acylglycerols and PEG ...
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A Highly Luminous LiCaPO4:Eu2+ Phosphor Synthesized by a Solution Method Employing a Water Soluble Phosphate Ester
... phate phosphors with even better photoluminescence properties can be greatly expanded. The condensed chain-structured phosphates are commercially available and are synthesized from a rather simple reaction among alcohol, ...
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Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
... Buccal drug delivery provides a promising route for the administration of APIs where avoidance of gastrointestinal degradation and hepatic first-pass metabolism is desired. However, efficient systemic drug delivery ...
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NANOSUSPENSION: AN ATTEMPT TO ENHANCE BIOAVAILABILITY OF POORLY SOLUBLE DRUGS
... the water. Poorly water-soluble drugs show many problems in formulating them in conventional dosage ...poorly soluble drugs is too low ...for drugs belonging to BCS CLASS ...
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Co-crystals: An opportunity for poorly soluble drugs
... the drugs, but among other techniques, Co-crystallization is the technique which is most randomly used to increase solubility and bioavailability as it doesn’t affect the pharmacological properties of the ...
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NANOSUSPENSION TECHNOLOGY FOR POORLY SOLUBLE DRUGS: AN OVERVIEW
... pertinent for those drugs that are dissolvable in either unpredictable organic dissolvable or partially water-miscible dissolvable. In the dispersed phase of the emulsion dissolvable can be utilized. High- ...
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Method for delivering drugs soluble in a vaporization vehicle
... This invention relates to a method for delivering drugs sublimable in a vaporization vehicle. The method involves combining a sufficient amount of a vaporization vehicle to sublime the drug and the drug to be ...
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