hiv-1 life cycle
Quantitative analysis of the time course of viral DNA forms during the HIV 1 life cycle
... of 1-LTRc (Figure ...the 1-LTRc quantifica- tion during infection by using Nalm-6 (ligase-4 + ) and Nalm-114 (ligase-4 - ) cells infected with HIV-1 Δenv vi- ruses, either WT or D116N (a ...
18
Inhibition of human immunodeficiency virus type 1 production in infected peripheral blood mononuclear cells by human leukocyte antigen class I-specific antibodies: evidence for a novel antiviral mechanism.
... virus life cycle by two different ...cell-free HIV-1 virions ...CD4 1 human cell lines by HIV-1 and HIV-2 grown in HLA class I-positive human cells whereas the same ...
8
Quantitative evaluation of the antiretroviral efficacy of dolutegravir
... second-generation HIV-1 integrase strand transfer inhibitor (InSTI) dolutegravir (DTG) has had a major impact on the treatment of HIV-1 ...the HIV-1 life cycle, as ...
8
Centrosomal pre integration latency of HIV 1 in quiescent cells
... of HIV-1 life cycle in quiescent cells even in the absence of cell activa- tion ...inhibit HIV-1 replication in resting cells in vitro, such as Murr1 [21] or APOBEC3G [16], the ...
7
Macrophage Inflammatory Protein 1α Inhibits Postentry Steps of Human Immunodeficiency Virus Type 1 Infection via Suppression of Intracellular Cyclic AMP
... type 1 (HIV-1) predominantly use chemokine receptor CCR5 to enter target ...protein 1 ␣ (MIP-1 ␣ ), MIP-1  , and RANTES, interfere with HIV-1 binding to CCR5 ...
7
Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1.
... As a measurement of completion of the early stages of the HIV-1 life cycle, the levels of viral DNA were examined by polymerase chain reaction amplification during infection by vif-posit[r] ...
5
Dual role of α defensin 1 in anti–HIV 1 innate immunity
... circular HIV DNA (E-DNA), considered a marker of nuclear import (46), was observed in α-defensin-1– or Go6976-treated cells (Figure 7B), suggesting that a block occurred at the step prior to completion of ...
10
Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication.
... During early stages of infection, the two PBS mutants, in conjunction with tRNA1Ls and tRNAPhe, appar- An early, critical step in the human immunodeficiency virus type HIV-1 life cycle i[r] ...
9
Irreversible Inhibition of Human Immunodeficiency Virus Type 1 Integrase by Dicaffeoylquinic Acids
... the life cycle of human immunodefi- ciency virus type 1 (HIV-1) and other retroviruses is integra- tion of the double-stranded DNA copy of the retroviral ge- nome into a chromosome of ...
8
Uracil DNA Glycosylase Is Dispensable for Human Immunodeficiency Virus Type 1 Replication and Does Not Contribute to the Antiviral Effects of the Cytidine Deaminase Apobec3G
... the life cycle of HIV, uracil occurs in the provirus either from misincorporation of dUMP during reverse transcription or from deamination of the minus-strand cDNA by ...into HIV-1 ...
8
Network-Based Analysis of OMICs Data to Understand the HIV-Host Interaction
... e.g., HIV-infected CD4+ T cells (Luo et ...the HIV life cycle can be ...with HIV can be used for this purpose (van Dijk et ...created HIV-1-human interspecies ...
44
HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products
... DNA life cycle stages have so far been done in murine ...sensing, HIV-1 DNA levels, and productive HIV-1 infection in human ...by HIV-1 despite the presence of ...
18
CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes
... virus life cycle events, including completion of reverse transcription, capsid uncoating, and nuclear trafficking and entry, and attenuates virus infectivity ...Overall, HIV-1 CA is poorly ...
19
Targets of Small Interfering RNA Restriction during Human Immunodeficiency Virus Type 1 Replication
... type 1 (HIV-1) replication in ...multiple HIV-1 RNA species during different steps of the retroviral life ...susceptible HIV-1 RNA species, siRNAs were first ...
14
Timing of the Components of the HIV Life Cycle in Productively Infected CD4+ T Cells in a Population of HIV-Infected Individuals
... Figure 1 provides a schematic of these and subsequent ...for HIV-1, blocking the interaction between HIV Env and this coreceptor ...lengthening HIV DNA chain during reverse ...
8
A role for the histone deacetylase HDAC4 in the life cycle of HIV 1 based vectors
... protein is a major player in cellular DSB repair and was reported by us and others to be involved in PIR [26-28]. At the same time, in these cells, we have overexpressed the HDAC4 protein. Since the normal HDAC4 protein ...
10
The Vpr protein from HIV 1: distinct roles along the viral life cycle
... of HIV-1 Vpr and phosphorylation of the protein is required ...cell cycle, such as cyclin- dependant kinases (CDKs), control progression through the cell cycle by reversible phosphorylation ...
14
Cholesterol, lipid rafts, and disease
... (35). HIV-1, which likewise incorporates host raft lipids and proteins into its envelope, employs rafts for at least four key events in its life cycle: pas- sage across a new host’s mucosa, ...
8
Life-time cost-benefit analysis of solar energy systems in Queensland
... while 1 kW of PV is estimated to provide a benefit of $750 when installed in residential areas with an evening peak and $1,500 when installed in commercial and industrial areas with a mid-afternoon ...
10
PubMedCentral-PMC4775030.pdf
... Malawi HIV-infected NHL population, our experience attests to the potential safety, effectiveness, and feasibility of CHOP in the current era, when accompanied by standardized monitoring, dose adjustment, support- ...
15