HIV-1 life cycle and replication
Quantitative analysis of the time course of viral DNA forms during the HIV 1 life cycle
... Results: Quantifying different types of viral DNA genome individually provides new information about the dynamics of all viral DNA forms and their interplay. For DNA L , we found that the 3 ′ -processing reaction was ...
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Productive Replication and Evolution of HIV-1 in Ferret Cells
... for HIV-1 has not been forthcoming, with the principal obstacles being species-specific restriction mechanisms and deficits in HIV-1 dependency ...nonreceptor HIV-1 dependency ...
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Original Article Tetraspanin CD63 is a regulator of HIV-1 replication
... February 1, 2015; Published February 15, 2015 Abstract: Macrophages and CD4 + T-cells are the major reservoirs for HIV-1 ...during HIV-1 replication in ...in HIV-1 ...
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Double Compartment CA Simulation of Drug Treatments Inhibiting HIV Growth and Replication at Various Stages of Life Cycle
... delay HIV progression and improve the quality of life of those who have become ...for HIV patients, it is important to have a realistic model which reliably simulates the course of the infection ...
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Inhibitory Effects of HIV-2 Vpx on Replication of HIV-1
... type 1 (HIV-1) and HIV-2 share a strik- ing genomic resemblance; however, variability in the genetic sequence accounts for the presence of unique accessory genes, such as the viral protein X ...
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The Vpr protein from HIV 1: distinct roles along the viral life cycle
... into HIV-1 virions and restores a mutation rate equivalent to that observed with the wt Vpr, both in actively dividing cells and in ...of HIV-1 to replicate in primary ...infectious ...
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Host hindrance to HIV 1 replication in monocytes and macrophages
... viral replication varies between individuals. Host determinants regulate HIV-1 replication in monocytes and macrophages, limiting several steps of the viral life-cycle, from ...
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Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid
... to HIV-1 CA: mutation of residues required for interaction affects early, preintegration events in the viral life ...of HIV-1 CA, based on computer docking solu- ...FIG 1 Effect ...
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An Inducible Human Immunodeficiency Virus Type 1 (HIV-1) Vector Which Effectively Suppresses HIV-1 Replication
... We have not yet elucidated the specific step in the viral life cycle which is affected by this vector, although it appears to occur at least in part during RT. In cotransfection studies, other investigators ...
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TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core
... As expected, infection by HIV-1 Q63A/Q67A exhibited reduced levels of HIV-1 2-LTR circles throughout (Fig. 1B, right panel). Altogether, these results suggested that the PIC is transported ...
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Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication
... show that the context of the reporter cassette is not a critical factor. Effect of lacZ ␣ orientation on the types of in vivo mutations. Although the integrated HIV-1 genome is double-stranded DNA, only one ...
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HIV 1 macrophage tropism is determined at multiple levels of the viral replication cycle
... of HIV-1 to infect macrophages is thought to be essential in AIDS ...Two HIV-1 isolates were able to establish a productive infection in MDM from all donors tested, whereas eight completely ...
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Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
... In contrast to previous reports, we found that each of the RT mutants we tested caused a modest but statistically significant de- crease in the fidelity of replication. The largest overall effect was seen with the ...
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A role for the histone deacetylase HDAC4 in the life cycle of HIV 1 based vectors
... Retroviral integration enhances the association of HDAC4 with vector DNA We note that HDAC4 was reported to associate with DNA of the avian sarcoma virus, but this association was detected only post-integration [24]. To ...
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Molecular strategies to inhibit HIV 1 replication
... Introduction HIV-1 is a lentivirus belonging to the retrovirus ...viral replication in vitro. HIV-1 primarily infects CD4 + T-lymphocytes and monocytes/macro- phages, but also ...
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DBR1 siRNA inhibition of HIV 1 replication
... suppresses HIV-1 replication during reverse transcription To more precisely determine the stage at which HIV-1 rep- lication is inhibited by degradation of DBR1 mRNA, we transfected ...
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Suppression of HIV 1 replication by microRNA effectors
... that HIV-1 post-integra- tion latency is a multi-factorial ...that HIV-1 gene expression is additionally regulated by the miRNA ...pathway. HIV-1 mRNA associates with components ...
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The dual role of tetraspanin CD63 in HIV 1 replication
... the HIV-1 replication ...in HIV-1 replication were ...during HIV-1 replication events occurring after proviral integration, and possibly during ...
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Dual role of autophagy in HIV-1 replication and pathogenesis
... and HIV-1 infection. Yet unknown is whether or not the ability of HIV-1 to promote auto- phagy in bystander CD4+ T cells renders those cells more susceptible to HIV-1 ...of ...
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Restriction of HIV-1 replication by unique TRIM22 isoforms.
... restrict HIV-1 replication and slow disease progression have all been linked to SNPs ...primary HIV-1 infection [145] stresses the importance of proper documentation and understanding ...
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