HMG CoA REDUCTASE ACTIVITY
Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method
... Conclusion The MVA quantification method presented here has been validated according to fit-for-pur- pose guidelines for biomarkers. The method displays precision (±15%CV) and accuracy (85–115%), and circumvents the ...
15
Regulation of cholesterol synthesis pathway. Cholesterol Synthesis. Cholesterol biosynthesis. Regulation of HMG CoA reductase activity
... acetyl CoA Glucagon cAMP g-6-P f-6-P f-1,6-diP 3-PG DHAP gly.P glu PEP pyr gly.P DHAP pyr acetyl Co A OAA malate OAA malate citrate pyr glu isocitrate succinate OAA G succ.CoA malate gly[r] ...
8
Inhibition Activity of HMG CoA Reductase by Rice Brain Extract and Its Fractions as Anticholesterolemia In vitro Study
... HMG CoA reductase inhibition effect of rice bran extract and its fractions were ...highest activity. Anti HMG CoA reductase activity of the extract and its ...
5
HMG-CoA reductase inhibitory activity and phytocomponent investigation of <em>Basella alba</em> leaf extract as a treatment for hypercholesterolemia
... Conclusion The present study provides preliminary data that suggest the B. alba leaf extract is capable of lowering cholesterol levels by inhibiting the HMG-CoA reductase activity. In ...
9
Identifying Mutations in Duplicated Functions in Saccharomyces cerevisiae: Recessive Mutations in HMG-CoA Reductase Genes
... HMG-CoA reductase activity assays of extracts from hmgl strains: T h e growth of diploids containing complementing mutant alleles of H M G l was dramat- ically slower th[r] ...
11
Towards Application of Bioactive Natural Products Containing Isoprenoids for the Regulation of HMG CoA Reductase—A Review
... the HMG-CoA reductase enzyme. HMG-CoA re- ductase has higher activity in the early stages of plant development and in the rapidly growing parts of plants, such as apical buds and ...
11
Bioactivity guided fractionation and hypolipidemic property of a novel HMG-CoA reductase inhibitor from Ficus virens Ait
... (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to meva- lonic acid ...the HMG-CoA reductase activity ...
15
Insilico predictions of inhibitors of novel statin structural analogues with HMG CoA reductase
... Objective of our study is to optimize the activity of statin group of drugs against HMG - CoA reductase. : Statin groups like Simvastatin, Lovastatin, Fluvastatin and Atorvastatin are selected ...
9
Aplexone targets the HMG CoA reductase pathway and differentially regulates arteriovenous angiogenesis
... the HMG-CoA reductase (HMGCR) ...the activity of geranylgeranyl transferase induces a venous angiogenesis phenotype resembling that observed in aplexone-treated ...the activity of Rac ...
9
3-HMG-CoA Reductase Inhibitors and Inflammation: Underlying Mechanisms and Role in Atherosclerosis
... The activity of the transcription factor NF-κB in circulating leukocytes is enhanced in patients with unstable angina and in healthy volunteers after a fat-enriched meal 31,32 ...this activity in ...
7
HMG-CoA Reductase Inhibitory Activity of Gnetum gnemon Seed Extract and Identification of Potential Inhibitors for Lowering Cholesterol Level
... antitumor activity in a colon tumor bearing ...agonistic activity with no cause of the damage to ...inhibitory activity, and molecular docking analysis indicated dimer of resveratrol was considered ...
7
Lagenaria siceraria ameliorates atheromatous lesions by modulating HMG–CoA reductase and lipoprotein lipase enzymes activity in hypercholesterolemic rats
... A t the end of study period that is on sixth day the overnight fasted rats were sacrificed under ether anesthesia. B lood was collected directly from the heart and stored at - 20 曟 for biochemical estimations. L iver was ...
8
HMG CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells
... In our experiments, simvastatin was shown to promote EPC proliferation, migration, and cell survival in vitro via the Akt signaling pathway, a finding that was con- firmed by functional blocking with dominant negative ...
8
Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA Reductase
... cholesterol activity biomarkers such as lathosterol would further support that the administration of supra-physiological doses of testosterone disturb the cholesterol metabolism in ...
6
3-HMG-Coa Reductase Inhibitor Modulates Parasitological Response in Malaria Patients Treated with Amodiaquine
... late parasitological failure (LPF) alongside sums up to an overall parasitological resistance of 9.7% and 32.8% in the test and control groups respectively. The underlying resistant mechanism to amodiaquine could be ...
6
Inhibitory roles of protein kinase B and peroxisome proliferator activated receptor gamma coactivator on hepatic HMG CoA reductase promoter activity
... markedly inhibited HMGR promoter activity (Figure 3). Co-transfection with both PGC-1 and TTP also resulted in very low levels of promoter activity. Since PGC-1 transfection acted to inhibit HMGR ...
5
Tumor specific HMG CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
... tumor-specific HMG-CoAR expression as a potential therapeutic option for breast can- ...of HMG-CoAR expres- sion in Chinese hamster ovary cells [28] and MCF7 breast cancer cells ...of HMG- CoAR ...
12
HMG CoA reductase inhibition by Simvastatin gets rat β Myosin heavy chain disappeared: A statin paradox
... 4. DISCUSSION Our work highlights the strict connection between HMGR main end-products and cardiac physiology show- ing that the inhibition of the enzyme, which catalyzes the key and rate limiting step of cholesterol ...
5
Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
... Side effects, such as hepatic transaminase elevation, sensory disturbances, and depression, have also been observed on prolonged use. 5 Instead of taking chemical drugs, many people today prefer natural products or ...
12
Chronic HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction
... mTOR activity is ...mTOR activity, and this effect was partially reversed by restoration of cholesterol to the membrane, suggesting that mTOR is involved in sensing cellular membrane sterol ...of ...
63