HMG CoA reductase or reductase
Original Article Malignant fibrous histiocytoma of visceral organs: clinicopathologic features and diagnostic value of ezrin and HMG-CoA reductase
... of HMG-CoA reductase, have been proved as chemopreventive drugs for variable ...of HMG-CoA reductase in most of the breast cancer cases, which was associated with an improved ...
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Aplexone targets the HMG CoA reductase pathway and differentially regulates arteriovenous angiogenesis
... Arterial and venous endothelial cells exhibit distinct molecular characteristics at early developmental stages. These lineage- specific molecular programs are instructive to the development of distinct vascular ...
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Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening
... atherosclerosis. HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-like drugs are inhibitors of human ...
12
An improved industrial process for synthesis of HMG-CoA reductase inhibitor Pitavastatin
... way. HMG-CoA reductase inhibitors are better antagonists for blocking the biosynthesis pathway of ...(or HMG-CoA reductase inhibitors) form a class of hypolipidemic agents, used ...
6
56. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ex vivo) by medicinal plants from western ghats
... A reductase has greater significance in cholesterol metabolism and, thus, has various health ...the HMG-CoA also blocks Coenzyme Q required for energy production and, thus, impairing cardiac and ...
6
Insilico predictions of inhibitors of novel statin structural analogues with HMG CoA reductase
... of HMG-Co A reductase with known crystal structure of four chains has been identified and down loaded from the National Centre for Biotechnology and the detail pertaining to the molecular properties of ...
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CHRONOPHARMACOTHERAPEUTIC RELEASE OF HMG COA REDUCTASE INHIBITOR: USING NOVEL COATING TECHNIQUE
... words, it is required that the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. [2] There are many conditions that demand ...
14
Towards Application of Bioactive Natural Products Containing Isoprenoids for the Regulation of HMG CoA Reductase—A Review
... isoprenoids. HMG-CoA reduc- tase is a rate-determining enzyme in mevalonate pathway, producing intermediates such as farnesyl and geranylgeranyl pyrophosphates, which lead to by-products such as ...of ...
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Role of HMG-CoA reductase inhibitors with curative radiotherapy in men with prostate cancer
... Abstract: Brachytherapy and external beam radiotherapy are effective and commonly used treatment modalities in men with localized prostate cancer. In this review, we explore the role of radiation therapy in the curative ...
10
3-HMG-CoA Reductase Inhibitors and Inflammation: Underlying Mechanisms and Role in Atherosclerosis
... An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in ...
7
7 Dehydrocholesterol–dependent proteolysis of HMG CoA reductase suppresses sterol biosynthesis in a mouse model of Smith Lemli Opitz/RSH syndrome
... of HMG-CoA reductase enzyme catabolism. Stability of HMG-CoA reductase was stud- ied in an in vitro system developed by Simoni and col- leagues, which employs a fusion gene ...
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Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
... specifically HMG-CoA reductase inhibitors, has been reported to have immunosuppressive effects in a study of heart transplant recipients ...of HMG-CoA reductase inhibitor, mostly ...
5
Pleiotropic effects of the HMG-CoA reductase inhibitors
... Abstract: The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These ...
11
The effect of aerobic training and consumption of L-carnitine supplements on Gen expression of HMG-CoA reductase and LDL receptor in the liver of male Wistar rats Injected by Boldenone
... LDL-R, HMG-COA reductase and PCSK-9 ...of HMG-COA increases the cholesterol synthesis inside the cell, but the increased PCSK-9 synthesis leads to the decomposition of LDL-R and ...
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Synthesis of HMG-CoA Reductase Inhibitor Lanost-8-en-3β-ol-7, 11-dione through Oxidation of 3β-acetoxylanost-8-en-7, 11-dione with Pyridinium Chlorochromate
... Allylic oxidation of 3B-acetoxylanost-8-ene was accomplished with pyridinium chlorochromate (PCC) and chromium trioxide/ acetic acid to form 3B- acetoxylanost-8-en-7,11-dione, which was later reduced to ...
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HMG-CoA reductase inhibitor lovastatin upregulates plasminogen activator production through RhoA-signaling in peritoneal cell line Met5A
... (HMG-CoA) reductase inhibitor statin, known to protect postoperative adhesion in animal model, affect the expressing tissue-type plasminogen activator (tPA) in peritoneal cells in ...of ...
5
Statins and Sepsis: Possible Connections and Therapeutic Implications
... mortality continues to increase. A delicate balance exists between widespread triggering of defence mechanism by invading micro-organisms and both direct/indirect effects of the micro-organisms and their products. It has ...
5
Chromatographic and spectrophotometric method for estimation of statin class drugs in bulk and in different dosage forms
... HMG CoA reductase inhibitors include Simvastatin, Mevastatin, Lovastatin, Atorvastatin, Fluvastatin, Rosuvastatin, Cerivastatin, Pravastatin, ...
7
Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli
... To balance MVA pathway flux, it is necessary to express the HMG-CoA reductase and MK at a higher level to decrease accumulation of HMG-CoA, and to eliminate the rate-limiting step. In ...
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Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory
... Glc , glucose; acetyl‑CoA, acetyl coenzyme A; tHMG1 , truncated HMG‑CoA reductase gene; HMG‑CoA, 3‑hydroxy‑3‑methylglutaryl‑CoA; IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl [r] ...
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