HOMOSERINE LACTONE
Positive Autoregulation of an Acyl Homoserine Lactone Quorum Sensing Circuit Synchronizes the Population Response
... acyl-homoserine lactone quorum-sensing ...acyl-homoserine lactone quorum sensing is that signal production is posi- tively ...acyl-homoserine lactone quorum sensing, but it ...
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Biochemical Detection of N-Acyl Homoserine Lactone from Biofilm-Forming Uropathogenic Escherichia coli Isolated from Urinary Tract Infection Samples
... acyl- homoserine lactone (acyl-HSL) signal molecules that serve in a cell-to-cell communication system termed quorum sensing ...Acyl-homoserine lactone, reported in more than 50 different ...
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Han, Shengcai (2017): Systemic responses of barley to the growth promoting, endophytic bacterium Acidovorax radicis N35 and role of 3-hydroxy-C10-homoserine lactone production in root colonization and plant perception. Dissertation, LMU München: Fakultät für Biologie
... N-acyl homoserine lactone (AHL) type in the perception by plants should be ...3-hydroxy-C10-homoserine lactone (3-OH- C10-HSL) as major ...
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The Quorum-Sensing Molecules Farnesol/Homoserine Lactone and Dodecanol Operate via Distinct Modes of Action in Candida albicans
... homoserine lactone, a quorum-sensing molecule secreted by Pseudomonas aeruginosa, block hyphal develop- ment by affecting cAMP signaling; they both directly inhibited the activity of the Candida adenylyl ...
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Acyl-Homoserine Lactone Based Modulators for RhlI, a Quorum Sensing Signal Synthase in Pseudomonas aeruginosa
... N-acyl-homoserine lactone (AHL) autoinducer based signal system, known as quorum sensing (QS), to modulate the gene expression for such traits as biofilm formation, toxin production, and antibiotic ...
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Production of phenylacetyl-homoserine lactone analogs by artificial biosynthetic pathway in Escherichia coli
... to phenylacetyl‑homoserine lactone analogs in E. coli In order to more effectively obtain an amount of the novel phenylacetyl-HSL analogs, we constructed a bio- conversion system for production of the novel ...
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Characterization of Acyl Homoserine Lactone of pigment producing Pseudomonas aeruginosa SU 3
... AHLs isolated in this study showed retention times of 3.054 and 4.659 which is assigned for C4-HSL and C5-HSL respectively (Figure 2), whereas Lade et al [24] assigned retention time of 3.224 for C4-HSL and 6.296 for C6- ...
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SYNTHESIS OF N-BUTANOYL L-HOMOSERINE LACTONE A PHARMACEUTICALLY IMPORTANT QUORUM SENSING DRUG Mahendra N. Lokhande*, Nilesh V Rathod, Sachin A Khiste, Dnyneshwar S. WankhedeDOWNLOAD/VIEW
... (R)-homoserine lactone by simple and efficient ...(R)-homoserine lactone (1) completed in five steps starting from monobenzyl protected 1,4- butane ...
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Identification, synthesis and regulatory function of the N-acylated homoserine lactone signals produced by Pseudomonas chlororaphis HT66
... might be 3-oxo or 3-OH-acyl-HSLs with side chains ranging from 6 to 10 carbons. To identify the signals more precisely, extracts were separated by preparative TLC, and then the corresponding parts were scrapped and ...
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Crystal structure of N (3 oxobutanoyl) L homoserine lactone
... which is a known quorum-sensing modulator, have been determined. The molecule exhibits signs of an intramolecular attractive carbonyl–carbonyl n!* interaction between the amide and lactone ester groups, ...
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Occurrence of N Acyl Homoserine Lactones in Extracts of Bacterial Strain of Pseudomonas aeruginosa and in Sputum Sample Evaluated by Gas Chromatography–Mass Spectrometry
... N-acyl homoserine lactones was developed and summarized in the literature [8-14, ...N-hexanoyl-L- homoserine lactone (HHL) and N-3-oxo-hexanoyl-L- homoserine lactone ...N-acyl ...
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Characterization of quorum sensing and quorum quenching soil bacteria isolated from malaysian tropical montane forest
... All Pseudomonas isolates, but not the Gram positive isolates, triggered CV026 violacein production suggesting production of short chain AHL (data not shown). The spent culture supernatants of QS bacterial isolates were ...
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Homoserine Toxicity in Saccharomyces cerevisiae and Candida albicans Homoserine Kinase (thr1Δ) Mutants
... of homoserine in the cell, and why does it result in such a plethora of phenotypes? We present evidence that homoserine acts as a toxic threonine analog; however, for three of the gene products that metabo- ...
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<p>Quorum quenching activity of <em>Bacillus cereus</em> isolate 30b confers antipathogenic effects in <em>Pseudomonas aeruginosa</em></p>
... Materials and methods: Soil bacteria were screened for aiiA gene coding for lactonase enzyme by Polymerase Chain reaction and sequencing of aiiA gene homologs. Lactonase activity and spectrum were assessed in the ...
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The roles of small RNAs: insights from bacterial quorum sensing
... Nonetheless, the functional group (usually fatty acid) ensures the specie-specificity [41] of quorum sensing. Majority of the gram-negative bacteria quorum sensing is regulated by highly conserved LuxR/LuxI family [48] ...
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Quorum Sensing in Microbial Virulence
... Erwinia carotovora sup. Carotovora releases several degrading enzymes acting on pectin, cellulose, and proteins. These enzymes are considered as virulence factors in soft-rot disease attacking plant tissues (9). ...
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Fungal Homoserine Kinase (thr1Δ) Mutants Are Attenuated in Virulence and Die Rapidly upon Threonine Starvation and Serum Incubation
... increased homoserine production (33), we predict that inhibitors of Thr1p (and Thr4p) would have a therapeu- tically beneficial synergistic action with inhibitors of other amino acid biosynthetic ...
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6α Acetoxyvouacapan 7β,17β lactone
... For centuries, in many cultures, plants have been the base of folk medicine. Of the 20 best-selling non-protein drugs in 1999, nine were derived from or developed as the result of leads generated by natural products, ...
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Dihydroparthenolide diol, a novel sesquiterpene lactone
... The reaction mixture was chromatographed on silica gel hexane–EtOAc 1:4 to afford colorless crystals of dihydroparthenolide diol in 85% yield.. Refinement The absolute configuration was [r] ...
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Dehydrobrachylaenolide: an eudesmane type sesquiterpene lactone
... isolated from Dicoma anomala Sond. (Asteraceae). The compound contains an endo–exo cross conjugated methyl- enecyclohexenone ring with an envelope conformation trans- fused with cyclohexane and trans-annelated with an - ...
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