Host-defense peptides (HDPs)
The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
... deacetylases; HDPs: host defense peptides; HEL: hen egg lysozyme; HIF-1-α: hypoxia-inducible factor 1-α; HLA- DR: human leukocyte antigen-antigen D related; HNP1: human α-defensin 1; IDRs: ...
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Host Defense Peptides in Wound Healing
... that host defense peptides play a major role in wound healing and wound infec- ...otics, HDPs have interesting features for topical application to treat wound infec- tion and promote ...
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Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides
... The inhibition of HIV vectors containing the HIV-1 enve- lope by LL37 and PG-1 were studied on P4CCR5 cells expressing CD4 and coreceptors. IC 50 s of 25 µg/ml and 14 µg/ml were observed for LL37 and PG-1, respectively ...
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Antimicrobial polymers : mimicking amino acid functionality, sequence control and three dimensional structure of host defense peptides
... antimicrobial host-defence peptides. The host-defence peptides have been identified as some of the most important leads for the next generation of antibiotics as they typically exhibit broad ...
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Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides
... scenario, host defense antimicrobial peptides offer an attractive solution to the increasing bacterial resistance problem, and have spurred considerable sci- entific ...Antimicrobial peptides, ...
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Structure–Activity Study, Characterization, and Mechanism of Action of an Antimicrobial Peptoid D2 and Its d- and l-Peptide Analogues
... Antimicrobial peptides (AMPs), also known as host defense peptides, are present in a broad variety of multicellular organisms ...Whereas peptides have an undeniable potential to become ...
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Enhancement of host defense against pathogens by antimicrobial peptides : a new approach to combat microbial drug resistance
... antimicrobial/host defense peptides need to be identified, but these preliminary results already seem to indicate the potency of this ...antimicrobial/host defense peptides have ...
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Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense
... Eukaryotic peptides are typically small and cationic, and are structurally classified into five major groups: 1) cysteine-stabilized ...of host defense peptides, particularly those of higher ...
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Aspergillus fumigatus: Principles of Pathogenesis and Host Defense
... Experimental studies performed in the early 1980s in immu- nocompromised mice indicate a critical role for macrophages in conidial defense and postulate that neutrophils act primarily against products of ...
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Hyperleptinemia is associated with impaired pulmonary host defense
... Pneumonia severity is increased in mice with isolated hyperleptinemia. To further determine whether the associ- ation between plasma leptin levels and pneumonia severity in the diet-induced obese mouse model represents ...
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Innate host defense against intracellular pathogens
... to host defense during early stages of mycobacterial infection, whereas induction of the selective autophagy pathway by overexpressing dram1 was ...in defense against intracellular bacterial ...
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Surfactant protein-D and pulmonary host defense
... In any case, SP-D can interact directly with host cells, and in some cases can influence their behavior. SP-D is chemotactic and haptotactic for neutrophils and certain mononuclear phagocytes [59 • ,67–69] and can ...
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Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype
... 2004a). Host defense systems must distinguish commensal organisms from episodic pathogens and regulate the ensuing responses precisely (O’Hara and Shanahan ...the host defense system, and ...
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Antimicrobial polypeptides in host defense of the respiratory tract
... Areas of ongoing scientific ferment are likely to include highly selective microsampling and analysis of the composition of respiratory secretions in specific locations in the respiratory system, including alveoli, small ...
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Modulating Iron for Metabolic Support of TB Host Defense
... important host response against Mtb, downregulation of the PPP could further increase flux through the glycolytic pathway thus supporting host immune cells ...
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Phytoalexin-Deficient Mutants of Arabidopsis Reveal That PAD4 Encodes a Regulatory Factor and That Four PAD Genes Contribute to Downy Mildew Resistance
... isolate involves a different signaling pathway for host responses than other RPP genes. Genetic dissection of host defense responses using the Arabidopsis model system is [r] ...
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Head to head comparison of the propensity score and the high-dimensional propensity score matching methods
... the hdPS method cannot be evaluated through the use of ordinary simulation studies since its perform- ance depends on the complexity and quantity of data available to the hdPS algorithm, levels of which ...
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Unique peptide maps of the three largest proteins specified by the flavivirus Kunjin.
... RESULTS Since host cell protein synthesis is not strongly inhibited by infection with flaviviruses 20, it is necessary to identify the peptides that are host coded in tryptic peptide map[r] ...
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Microglia Are Critical in Host Defense against Prion Disease
... ABSTRACT Microglial cells in the central nervous system play important roles in neurodevelopment and resistance to infection, yet microglia can become neurotoxic under some conditions. An early event during prion ...
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An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection
... To determine a role in host defense against influenza A virus IAV infection and to find the underlying defense mechanism we developed transgenic mouse models that are deficient in BPIFA1[r] ...
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