hot melt granulation method
Hot-Melt Coating: An Innovative Pharmaceutical Coating Technique.
... the particle flow (as opposed to top-spray). Substrates with poor fluidization characteristics such as larger particles and/or particles of higher density are difficult to coat with the top spray mode, and the bottom ...
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Formulation and Evaluation of Ritonavir Immediate Release Tablets by Hot Melt Extrusion Method
... wet granulation method F5 shows highest % drug release (99 %) at 120 mins The optimized formulation was subjected to accelerated stability studies at a temperature and relative humidity of 40 C 75% 5% H for ...
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Preparation and evaluation of drotaverine hydrochloride orally disintegrating tablets using melt granulation
... drug-polymer melt granules Taste masked melt granulations of drotaverine HCl were prepared by using either compritol or precirol using varying drug- polymer ratios of 1:1, 1:2, 1:5, and ...a hot ...
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Hot melt extrusion method for preparation of ibuprofen/sucroester WE15 solid dispersions: evaluation and stability assessment
... Previous literature had discussed various preparations of IBU/ SDs for improving its dissolution using different carriers (Dabbagh and Taghipour, 2007; Esnaashari et al., 2005; Islam et al., 2010; Newa et al., 2007; Newa ...
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FORMULATION AND EVALUATION OF GASTRO RETENTIVE MATRIX TABLETS OF ATENOLOL USING MELT GRANULATION TECHNIQUE
... ABSTRACT: The main objective of this present work was to develop and evaluate matrix tablets of Atenolol by melt granulation technique and compare the drug release between bess wax and glyceryl monostearate ...
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FORMULATION AND EVALUATION OF DICLOFENAC SODIUM SUSTAINED RELEASE TABLETS USING MELT GRANULATION TECHNIQUE
... wet granulation, melt granulation and extrusion, are ...by melt granulation technique and this granules were shifted and compressed in to ...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LOSARTAN POTASSIUM USING MELTGRANULATION TECHNIQUE
... FTIR study was carried out to check compatibility of drug with polymers. Infrared spectrum of Losartan potassium was determined on Fourier transform infrared spectrophotometer using KBr dispersion method. Then the ...
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FORMULATION AND EVALUATION OF ZOLPIDEM TARTRATE LAYERED TABLETS BY MELT GRANULATION TECHNIQUE FOR TREATMENT OF INSOMNIA
... Vol 11, Issue 6, 2018 Online 2455 3891 Print 0974 2441 FORMULATION AND EVALUATION OF ZOLPIDEM TARTRATE LAYERED TABLETS BY MELT GRANULATION TECHNIQUE FOR TREATMENT OF INSOMNIA RAMYA SRI A, LATHA K* Dep[.] ...
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FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF VENLAFAXINE HCl
... The drug-excipient interaction study was carried out using Fourier transform infrared spectroscopy (FT-IR) by KBr pellet method. To study the compatibility of various formulation excipients with Venlafaxine HCl, ...
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ENHANCEMENT OF DISSOLUTION RATE AND SOLUBILITY OF LOSARTAN POTASSIUM BY USING SOLID DISPERSION METHOD β CYCLODEXTRIN AS CARRIER
... the hot melt extrusion method is that the drug/carrier mix is only subjected to an elevated temperature for about 1 min, which enables drugs that are somewhat thermo labile to be ...
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Formulation and evaluation of diltiazem hydrochloride extented release tablet by melt granulation technique
... The granules obtained by melt granulation were characterized by carrying out particle size distribution by sieve analysis and by IR to study the drug-binder compatibility. The results are shown in figure ...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF DILTIAZEM HYDROCHLORIDE BY MELT GRANULATION TECHNOLOGY
... by melt granulation technology and to study the effect of various concentrations of polymers on release rate from ...FTIR method using KBr pellet method. The granules prepared by melt ...
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THE ROLES OF CHANNELING AGENTS ON THE DRUG RELEASE FROM WAX MATRIX TABLETS PREPARED BY MELT GRANULATION
... The study aimed to investigate the effect of the channeling agents and to explore the mechanisms by which they affect the drug release from wax matrix tablets. The channeling agents were potato starch and icing sugar. ...
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SOLUBILITY ENHANCEMENT OF BOSENTAN MONOHYDRATE BY USING HOT MELT EXTRUSION TECHNIQUE
... using hot-melt extrusion tech- ...employing hot-melt extrusion technique, which resulted in enhanced solubility and dissolution rate of the drug and it can be assessed further bioavailability ...
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“A Novel Practical Approach for Enhancement of Bioavailability of Poorly Water Soluble Drug by Hot Melt Coating Technique” by D. S. Khobragade, Jitendra Wankar, A. T. Patil,M. S. Potbhare, C. L. Lakhotiya, S. N. Umathe, India.
... using hot plate and was maintained in molten state with continuous stirring using magnetic ...For hot melt coating, modified coating spray gun was ...
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DESIGN AND IN VITRO EVALUATION STUDIES OF DICLOFENAC SODIUM FLOATING MATRIX TABLETS BY MELT GRANULATION TECHNIQUE
... by melt granulation ...by melt granulation technique by using polymers such as Hydroxy propyl methyl cellulose(HPMC K15M), ethyl cellulose, bees wax alone or in combination with cetyl alcohol, ...
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Formulation and evaluation of tramadol hydrochloride extended release tablet by using hydrophilic and hydrophobic polymers
... wet granulation and melt granulation ...wet granulation of hydrophilic polymer followed by wax addition method and melt granulation of wax followed by polymer addition ...
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Hot melt extrusion technique and its pharmaceutical applications: A review
... [11]. Hot-melt extrusion is the process of pumping raw materials with a rotating screw under elevated temperature through a die into a product of uniform ...
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Different Solid Dispersion Techniques for Dissolution Enhancement Using Paracetamol as a Model Drug
... As observed from Table 1, the percentage yield was generally high for PCT SDs prepared using EUD, mannitol and PEG. On the other hand, PVP and HPMC showed lower yield percentages, which may be due to sticky and viscous ...
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Production of Solid Lipid Nanoparticles Drug Loading and Release Mechanism
... as hot homogenization which includes dispersion or dissolving or solubilisation of the drug in the melted ...Another method to minimize the loss of hydrophilic drug to aqueous phase is to replace water with ...
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