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HOX protein

Collaboration between Smads and a Hox protein in target gene repression

Collaboration between Smads and a Hox protein in target gene repression

... extent Hox target gene selection is dependent upon other regulatory factors and how these interactions might affect target gene activation or ...the Hox protein Ultrabithorax (Ubx) to directly ...

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Fattening the perspective of Hox protein specificity through SLiMming

Fattening the perspective of Hox protein specificity through SLiMming

... of Hox proteins allow addressing the issue of SLiM functional importance from a wider ...Drosophila protein Ubx, for which small deletions were generated upstream of the HD (Tour et ...HoxA1 protein, ...

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Cellular and molecular insights into Hox protein action

Cellular and molecular insights into Hox protein action

... on, Hox genes assist cells in migration and, in the case of the central nervous system, in establishing networks and circuits (Gavalas et ...elegans, Hox proteins also contribute to control neuroblast cell ...

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Roles of cofactors and chromatin accessibility in hox protein target specificity

Roles of cofactors and chromatin accessibility in hox protein target specificity

... on Hox specificity [12, 13], how these extrapolate to the in vivo situation is currently ...investigated Hox protein and cofactor binding and have identified Hox binding sites and target genes ...

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Investigating the functional significance of evolutionarily conserved protein motifs of the Drosophila melanogaster HOX protein, Sex combs reduced

Investigating the functional significance of evolutionarily conserved protein motifs of the Drosophila melanogaster HOX protein, Sex combs reduced

... melanogaster, Hox gene expression in spatially restricted domains along the A-P axis of the embryo determines segmental ...of HOX control of development is essential for understanding body patterning in ...

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Investigating HOX Protein Requirement for Tarsus Determination in Drosophila melanogaster

Investigating HOX Protein Requirement for Tarsus Determination in Drosophila melanogaster

... of Hox genes potentially involved in tarsus determination. These Hox genes are, Sex combs reduced (Scr), Antennapedia (Antp), and Ultrabithorax (Ubx), which have an integral role in thorax development ...

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A comprehensive catalog of post-translational modifications of Drosophila melanogaster HOX protein, Sex combs reduced

A comprehensive catalog of post-translational modifications of Drosophila melanogaster HOX protein, Sex combs reduced

... Bottom-up MS/MS analysis of SCRTT purified from developing D. melanogaster embryos identified many amino acid residues that were covalently modified. This is the first report of the identification of PTMs, most ...

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Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax

Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax

... Ubx protein expression in mid-stage 11 embryos of the following genotypes: (D) wild type, (E) ectopically expressed Ubx at 76% of endogenous levels and (F) ectopically expressed Ubx at 32% of endogenous ...Ubx ...

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Pleiotropic functions of a conserved insect specific Hox peptide motif

Pleiotropic functions of a conserved insect specific Hox peptide motif

... derived Hox protein Fushi Tarazu (Ftz) have also demonstrated that beetle (Tribolium castaneum) Ftz has distinct homeotic and segmentation functions that are differentially mediated by a YPWM motif and a ...

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Chromatin accessibility plays a key role in selective targeting of Hox proteins

Chromatin accessibility plays a key role in selective targeting of Hox proteins

... individual Hox proteins in Kc167 cells has clear effects on Hox binding, generally resulting in an increase in the number of significant Hox binding sites, promotion of chromatin opening, and a shift ...

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Segment specific prevention of pioneer neuron apoptosis by cell autonomous, postmitotic Hox gene activity

Segment specific prevention of pioneer neuron apoptosis by cell autonomous, postmitotic Hox gene activity

... could be transcribed in both anterior and posterior dMP2s, with post-transcriptional mechanisms – or regulation of other genes downstream of rpr – accounting for the differential survival of anterior and posterior dMP2s. ...

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Two more Posterior Hox genes and Hox cluster dispersal in echinoderms

Two more Posterior Hox genes and Hox cluster dispersal in echinoderms

... the Hox cluster One of the most striking observations about Hox11/13d and e in ...the Hox cluster (scaffold 628 in the ...annotated protein-coding genes (based on the automated NCBI genome annota- ...

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Hox Gene Collinearity May Be Related to Noether’s Theory on Symmetry and Its Linked Conserved Quantities

Hox Gene Collinearity May Be Related to Noether’s Theory on Symmetry and Its Linked Conserved Quantities

... as Hox Gene Collinearity (HGC) can be easily incorporated in the present ...the Hox genes is a very surprising event that proved later to be a universal property widespread to most animal clades where the ...

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The significance of Hox gene collinearity

The significance of Hox gene collinearity

... ous Hox genes, at least not in Drosophila. Indeed, it is suggested that Hox genes in Drosophila function as independent modules, operating in a parasegment specific manner, and each with its own PRE and ...

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Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects

Knockdown of the complete Hox paralogous group 1 leads to dramatic hindbrain and neural crest defects

... defects in the hindbrain and associated nerves in the region between r3 and r8 (Carpenter et al., 1993; Chisaka et al., 1992; Dolle et al., 1993; Lufkin et al., 1991; Mark et al., 1993). In the Hoxb1 knockout the ...

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Vol 70, No 3 (2018)

Vol 70, No 3 (2018)

... homeobox protein Hox-B4; TNC –total nucleated cells; CFU – colony forming unit; MSC – mesenchymal stem cells; BM – bone marrow; SCF –stem cell factor; FLT3L – FMS-like tyrosine kinase 3 ligand; TPO ...

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Some Questions and Answers About the Role of Hox Temporal Collinearity in Vertebrate Axial Patterning

Some Questions and Answers About the Role of Hox Temporal Collinearity in Vertebrate Axial Patterning

... 4 Hox clusters and that these effects were induced by 8 different manipulations of 7 different Hox genes leave no doubt that Hox interactions have a general role in ...between Hox clusters, ...

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Evolutionary shifts of vertebrate structures and Hox expression up and down the axial series of segments: a consideration of possible mechanisms

Evolutionary shifts of vertebrate structures and Hox expression up and down the axial series of segments: a consideration of possible mechanisms

... Subsequently, Hox clusters become functionally ac- tivated, 3' to 5', within the emergent mesodermal cells at a rate, and to a final extent, that is proportional to their endogenous concentration of ...cause ...

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The puzzle of Hox genes

The puzzle of Hox genes

... Int I De> Bini 38 557 56 1( 199~) 557 Relliew The puzzle of Hox genes ANDRES E CARRASCO' and SILVIA L LOPEZ Laboratorio de Embriologia Molecular, Insrituto de 8;010gla Celular, Facultad de Medicina, U[.] ...

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Composition and genomic organization of arthropod Hox clusters

Composition and genomic organization of arthropod Hox clusters

... of Hox genes [1, 12], there are an increasing number of examples of lineage-specific Hox gene ...of Hox genes have been previously observed via PCR surveys in several non-insect arthropods, ...entire ...

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