Hsp90 inhibition
Targeting HSF1 sensitizes cancer cells to HSP90 inhibition
... of HSP90 inhibition, we performed pooled shRNA screening to search the potential combinational targets of HSP90 inhibitor, and identified HSF1 as a sensitizer of HSP90 ...to HSP90 ...
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FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism.
... direct HSP90 substrates, it is important to note that the FGFR3 kinase itself is a bona fide HSP90 client protein (32, ...selective HSP90 inhibitors, with FGFR3 representing the member most sensitive ...
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Antimicrobial, Anti Inflammatory and Anti Parkinson’s Screening of Imine Analogues through HSP90 Inhibition
... inflammation. HSP90 associates with eNOS and stimulate production of nitric ...of HSP90, its ability to produce NO depends upon HSP90. So when HSP90 is inhibited eNOS is down-regulated and ...
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Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells
... The Hsp90- based molecular chaperone complex interacts with its client proteins in an iterative ...way. Hsp90 cycles are driven by ATP- or ADP-bound conformations that are mediated via multiple rounds of ...
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Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations
... that Hsp90 inhibition by non-toxic concentrations of the geldanamycin derivative 17-DMAG significantly blocked T cell proliferation, reduced IFN- γ and IL-17 expression on CD4 + T lymphocytes, and arrested ...
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Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)
... by Hsp90 inhibition, which enhances the association of chaperones with mutant IMPDH1 protein aggregates that subsequently favour or promote degradation of mutant aggregates via the proteasome system as ...
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Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs
... to Hsp90 inhibition as v1 and v2 but not v3a were found to be sensitive to 17-DMAG ...to Hsp90 inhibitors is a property of disruption of the WD repeat region ...to Hsp90 inhibition, ...
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Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro
... the inhibition of HSP90 showed significant antiviral ...the inhibition of HSP90 could be a promising broad-range antiviral ...of HSP90 inhibition on PRRSV infection have not been ...
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Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress Response but No Stage Differentiation
... of HSP90 and inhibit the specific chaperone function of this HSP (6, 18, 25, ...on HSP90 activity to attain their respec- tive active or responsive conformation (20, ...of HSP90 family members, as ...
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Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.
... Further studies are required to elucidate the complex and multiple mechanisms that can underlie the alternative splicing disruption observed upon HSP90 inhibition. A previous study identified the ...
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NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo
... of HSP90 inhibition, and found a dose-dependent upregulation of HSP70 expression after 24 h in PC12 cells treated with ...instance, inhibition of both AKT and ...
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Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension
... HSP90 and the co-chaperone adaptor CDC37. As such, we assessed expression changes of these genes by real- time PCR and western blot analysis. While no significant changes in mRNA levels were observed, CDK4 protein ...
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Hsp90 Is Essential for Chl1-Mediated Chromosome Segregation and Sister Chromatid Cohesion
... of Hsp90 function exhibits a defect in chromosome segregation to the same extent as that of the chl1 deletion ...and Hsp90 has been associated with the chromosome loss phenotype earlier ...and Hsp90 ...
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Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922
... The inhibition of heat shock protein 90 (Hsp90) a molecular chaperone for multiple oncogenic client proteins is considered as a promising approach to overcome ...most Hsp90 inhibitors activate HSF-1 ...
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HSP90 Protects the Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Oncoprotein from Proteasomal Degradation To Support NF-κB Activation and HTLV-1 Replication
... degradation. HSP90 inhibitors such as geldanamycin and 17-DMAG potently induce the degra- dation of HSP90 client proteins (40, ...Known HSP90 client proteins IKK␣, IKK  , NEMO, AKT, and TBK1 (42–46) ...
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HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells
... and inhibition of HSP90 seems to affect cHL cell ...of HSP90 inhibition by geldanamycin derivative 17-AAG or RNA interference (RNAi) on aberrant Jak-STAT signaling in cHL ...complete ...
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Inhibition of heat-shock protein 90 sensitizes liver cancer stem-like cells to magnetic hyperthermia and enhances anti-tumor effect on hepatocellular carcinoma-burdened nude mice
... of HSP90 was determined by Western blotting after 10 minutes, 4 hours, 8 hours, 12 hours, and 24 hours of culture time after heat ...the inhibition of HSP90 could sensitize CD90 + LCSCs to magnetic ...
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<p>MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma</p>
... inhibit Hsp90 expression is crucial for effective Hsp90 ...of Hsp90 gene. 25 Herein, we demonstrated that miR-27a reduced Hsp90 expression not only at the levels of translation, but also ...
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Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer
... known Hsp90 inhibitors depletes the Hsp90-dependent proteins in a concentration-dependent fashion [18, 19], our results also showed CS-6 could affect Hsp90 “client” proteins ...to Hsp90 and ...
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Original Article Hsp90 protects LPS induced pancreatic inflammation of AR42J cells by inhibition of p38MAPK/NF-κB pathways
... [30-32]. AP is a clinical entity which is charac- terized by the abnormally activation of pancre- atin in pancreatic acinar cell and autodigestion of pancreas [33]. Digestive enzymes and lyso- somal enzymes were ...
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