Human Disease Genes, Identification of
Linkage Disequilibrium and the Mapping of Human Disease Genes
... Family-based linkage disequilibrium mapping using SNP markers is expected to be a major route to the identification of susceptibility alleles for complex diseases. However there are a number of methodological ...
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Constructing an integrated gene similarity network for the identification of disease genes
... Results: We proposed a novel method, named RWRB, to infer causal genes of interested diseases. First, we construct five individual gene (protein) similarity networks based on multiple genomic data of human ...
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Identification of Cellular Genes Affecting the Infectivity of Foot-and-Mouth Disease Virus
... Foot-and-mouth disease virus (FMDV) produces one of the most infectious of all livestock diseases, causing extensive economic loss in areas of ...cell genes to accomplish the entry, replication, and release ...
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The human disease network in terms of dysfunctional regulatory mechanisms
... say disease and normal, the differential coexpression measure, dC, was defined as the Euclidean distance of two contrastive coexpression profile of the gene under two conditions ...Simultaneous ...
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Large scale identification of human genes implicated in epidermal barrier function
... from human epidermis have been performed so far (relative to other organs), genes expressed during the late steps of epidermis differentiation are poorly represented in sequence ...3,375 genes from ...
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Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous families
... yeast genes are lethal when knocked out ...mouse genes in the homozygous state ...each human gene to test its viability cannot be done experimentally, naturally oc- curring mutations that effectively ...
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Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease
... Notes: (A) Heatmap of significantly regulated genes with 2.5-fold induction in individual tissue samples (one-way analysis of variance with Benjamini–Hochberg correction, cutoff p-value 0.05). (B) Histologic ...
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In Silico Identification of Novel Candidate Drug Targets in Haemophilus Influenzae Rd KW20
... respiratory disease is Non-Typeable Haemophilus influenzae ...Pulmonary Disease (COPD) and bronchiectasis ...Essential Genes (DEG) of ...essential genes, the predicted non-human ...
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Detection and Molecular Identification of Plasmid Virulence Genes in Salmonella enterica serovar typhimurium Isolated from Human and Animals by Multiplex PCR Method
... plasmid genes with multiple- drug resistance factors, systemic disease, source of Salmonella (human or animals) and bacterial virulence (12, 14, 16-17, 20, 26, 30- 31, ...from human and animal ...
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Identification of candidate genes for devil facial tumour disease tumourigenesis
... (DFT) disease, a transmissible cancer where the infectious agent is the tumour itself, has caused a dramatic decrease in Tasmanian devil numbers in the ...perturbed genes or pathways in ...selected ...
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An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer’s disease
... In our search for novel compounds with neuroprotec- tive effects against glutamate neurotoxicity, we focused in a class of compounds, the angiotensin receptor blockers (ARBs) or sartans, that effectively blocks the ...
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Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis
... PPI network construction and analysis of modules The STRING database (http://string-db.org/) is an on- line software that aims to provide a critical assessment and integration of protein–protein interactions, including ...
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Integrative analysis reveals disease-associated genes and biomarkers for prostate cancer progression
... identified genes and pathways in cancer ...indicating genes as biomarkers in complex diseases tend to cluster together on well-connected proteins interac- tion ...
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Comparative transcriptome analyses of Pseudomonas aeruginosa
... 5,570 genes of ...reductase genes indicating that the mode of action of bleach in inducing the oxidant defence system genes is similar to that of hydrogen ...peroxide. Genes involved in the ...
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TnphoA and Its Use in Transposon Mutagenesis
... One example of how this approach has been success- fully used can be found in the case of bex locus in en- capsulated Haemophilus influenzae. A 5.1 kb region in the capsulation locus of H. influenzae was determined using ...
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Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms
... and genes involved with the eDNA export mechanism were ...of genes belonging to a unique genomic region, as well as numerous mutants involved in metabolism and energy ...in genes encoding proteins ...
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Identification of Glutaminyl Cyclase Genes Involved in Pyroglutamate Modification of Fungal Lignocellulolytic Enzymes
... ABSTRACT The breakdown of plant biomass to simple sugars is essential for the pro- duction of second-generation biofuels and high-value bioproducts. Currently, enzymes produced from filamentous fungi are used for ...
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Identification of novel insertion elements, restriction fragment length polymorphism patterns, and discontinuous 23S rRNA in Lyme disease spirochetes: phylogenetic analyses of rRNA genes and their intergenic spacers in Borrelia japonica sp nov and genomic group 21038 (Borrelia andersonii sp nov ) isolates
... Lyme disease possess an rRNA gene organization consisting of a single 16S rRNA gene followed by a spacer of several kilobases and a tandem repeat of a 23S (rrl)-5S (rrf) rRNA gene ...these genes have been ...
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Identification of genes related to floral organ development in pak choi by expression profiling.
... Another 32 genes were analyzed by comparing them with their homologs in A. thaliana. The Bra001598 homolog is a primary auxin-responsive gene that is involved in the regulation of stamen filament development in ...
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Identification of Genes involved in Postaxial Polydactyly, Sample of FATA territory, Pakistan
... denser and flatten, and chondrogenic differentiation is inhibited. This creates an „interzone‟, the site of the future cell death that creates the joint space. Two genes, Gdf5and Nog, which encode a BMP-related ...
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