human epidermal growth factor receptor-2 (HER-2) receptor
6100.pdf
... EGFR(epidermal growth factor receptor) and the related HER-2 (human epidermal growth factor receptor 2) associated with breast cancer has ...
46
Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer
... of human epidermal growth factor receptor (HER)2 and other receptor tyrosine ...estrogen receptor (ER)+ breast cancer cells, PI3K activation promotes estrogen- ...
12
Case Report Mammary carcinoma with osteoclast-like giant cells: a case report
... that 2% of breast carci- noma ...estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, receptor activator of nuclear-kB, ...
6
Prognostic Implications of ER, PR and HER2/Neu Protein Expression in a Cohort of Breast Carcinoma
... HER 2/neu was positive in 25% of patients with distant metastasis and ...of human epidermal growth factor receptor including the risk of brain ...predictive factor for ...
6
Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
... of epidermal growth factor receptors (EGFRs) or ERBB receptors has attracted great attention in the literature ...(HER1/c-erbB1), human epidermal growth factor ...
8
Immunohistochemical profile and its association with clinicopathological parameters in carcinoma breast: a prospective study in central India
... (PR) receptor and Her-2/neu (human epidermal growth factor receptor type 2) analysis have been accepted as established procedures in routine management of the ...
7
New developments in the treatment of HER2-positive breast cancer
... the human epidermal growth factor receptor-2 (HER2) tyrosine ...of epidermal growth factor receptor and HER2 tyrosine kinases, and is approved for ...
12
PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients
... with tamoxifen resistance. In our primary analysis, we tested the clinical validity of these molecular alterations as single markers, analyzed as binary factor. Covariate adjusted Cox proportional hazard ...
10
The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study
... Total RNA from tumor tissues was extracted using Trizol (Thermo Fisher Scientific, Waltham, MA, USA) according to the manufacturer’s instructions. Real-time quantitative poly- merase chain reaction (qPCR) was carried out ...
11
<p>The Role Of Circulating Tumor DNA In Therapeutic Resistance</p>
... ctDNA-NGS has recently been investigated as a formid- able platform to develop noninvasive blood tests. The purpose of this approach is to complement and further enhance the currently available screening and diagnostic ...
13
The progress of targeted therapy in advanced gastric cancer
... Approximately one million people are diagnosed each year with gastric cancer, making it the fourth most com- mon cancer and the second leading cause of cancer re- lated death worldwide with an estimated 800,000 deaths ...
8
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways
... the human epidermal growth factor receptor 2 (HER2) (ERBB2) proto-oncogenic receptor, tyrosine ...chemotherapy. 2 Breast tumors are also molecularly subtyped based ...
13
Receptor conversion in distant breast cancer metastases
... study receptor conversion for estrogen receptor alpha (ERa), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in a large group ...
9
Prognostic significance of Human epidermal growth factor receptor 2 expression in patients with resectable gastric adenocarcinoma
... HER2 2+ in IHC and amplified HER2 gene levels based on FISH (or SISH) were 4% [11], ...HER2 2+ IHC specimens due to the high cost of implementing ...HER2 2+ in IHC, we defined only HER2 3+ in IHC as ...
9
Role of lapatinib in the first-line treatment of patients with metastatic breast cancer
... of epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth factor receptor 2 ...
13
Precision medicine in breast cancer: reality or utopia?
... estrogen receptor; PgR: progesterone receptor; AR: androgen receptor; HER2: the oncogenic human epidermal growth factor receptor 2; PTEN: phosphatase and ...
13
Optimising endocrine therapy in postmenopausal women with advanced breast cancer
... 2012 Randomized Phase II Trial of Everolimus in Combination With Tamoxifen in Patients With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast[r] ...
26
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
... estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), represents the most aggressive and mortal subtype of breast ...
16
Pancreatic metastasis from invasive pleomorphic lobular carcinoma of the breast: a rare case report
... estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, E-cadherin, gross cystic disease fluid protein 15 and mammaglobin, which ...
5
Positron emission tomography in breast cancer: 18F- FDG and other radiopharmaceuticals
... HER2: Human epidermal growth factor receptor 2; HR: Hormone receptor; IDC: Invasive ductal carcinoma; IHC: Immunohistochemistry; ILC: Invasive lobular carcinoma; ISH: In ...
19