Human mesenchymal progenitor cells
Modeling appendicular skeletal cartilage development with modified high-density micromass cultures of adult human bone marrow-derived mesenchymal progenitor cells
... of cells in this study to validate the system, we envision employ- ing this culture and method on cells derived from indi- vidual donors reflecting patient diversity and potentially replicating a population ...
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Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells’ homeostasis
... in human bone marrow [19] and adipose MSC [20] in elderly individuals, we found low to undetectable levels of SABG (below 10%) in all early passage cultures tested, irrespective of their age (data not ...
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Activin A expression regulates multipotency of mesenchymal progenitor cells
... skeletal muscle (M). In line with the current state of knowledge of the biology of BM‑derived MPCs, we carried out direct comparisons of the phenotypic and functional properties of MPCs isolated from these different ...
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Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? A Perspective from Space Flight and Model Systems
... of human MSC, so it was not possible to make conclusions regarding whether only a subpopulation of MSC were affected by the microgravity conditions ...cloned cells to allow stronger conclusions to be ...
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Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells
... to human MPCs was shown to suppress the osteogenic medium- induced morphological change from spindle to cuboidal shape and also ALP ...2 cells of the same patients; this characteristic is contrary to what ...
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Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis
... target cells, where the exogenous exosomal molecules can regulate target gene or protein expression and recipient cell function [6, ...stem cells-like pro-regenerative effects in injured tissues and avoid ...
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Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage
... in human articular cartilage ...of cells such as endothelial cells, activated macrophages, fibroblasts, smooth muscle cells, and the vast majority of human cartilage chondrocytes ...
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Human ethmoid sinus mucosa: a promising novel tissue source of mesenchymal progenitor cells
... genitor cells in the MS mucosa [17,19,20], there are no reports identifying and isolating MPCs from the paranasal sinus mucosa or comparing the properties of MPCs by tis- sue source within the sinonasal ...in ...
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Vascular stem cells in diabetic complications: evidence for a role in the pathogenesis and the therapeutic promise
... adult human bone marrow ...other progenitor cell types, MPCs share properties of both stem cells and mature ...population. Mesenchymal cells in culture typically exude a spindle-like ...
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Transdifferentiation of human adipose-derived mesenchymal stem cells into oligodendrocyte progenitor cells
... condition at 4 °C overnight. For this purpose, anti- A2B5 FITC antibody (1 µg/ml Abcam, Cambridge, MA, USA), anti-oligodendrocyte transcription factor (Olig2) FITC antibody (1:1000; Abcam, Cambridge, MA, USA), anti- ...
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Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation
... 4 cells/cm 2 in the lower chamber, and ADHLSCs were seeded on the collagen- coated membrane insert at different densities to ob- tain ratios of 0:1, 1:100, 1:10, and ...
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Characterization of a migrative subpopulation of adult human nasoseptal chondrocytes with progenitor cell features and their potential for in vivo cartilage regeneration strategies
... from human articular cartilage chemotactically respond to growth factors such as platelet-derived growth fac- tor (PDGF)-BB and insulin-like growth factor 1 (IGF-1) [30] in a comparable manner to ...
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Unveiling mesenchymal stromal cells’ organizing function in regeneration
... Multilineage potential of adult human mesenchymal stem cells. A., Mesenchymal stem cells in tissue growth and repair[r] ...
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Current perspectives in stem cell research for knee cartilage repair
... stem cells, including their reduced potentiality with age and disease, like in osteoarthritis with an inflammatory environment, the effects of cellular aging ...
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The Purification of Human Adult Progenitor Cell Types to Promote Angiogenesis
... as cells differentiate 30, 31 ...proliferative progenitor cells that drive expansion and subsequently generate more differentiated endothelial cells with lower proliferative rates and ...
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The curative effect of the associated cell transplantation on the rabbit myocardial infarction
... Inducing Mesenchymal stem cells to differenti- ate into cardiomyocycte-like cells and endothe- lial progenitor cells orientedly and evaluating the curative effect of the associated cell ...
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Perspectives on endogenous and exogenous tissue engineering following injury to tissues of the knee
... In a number of studies resulting from investigations from the Nakamura laboratory at Osaka University, and in collaboration with the author, Tissue Engineered Constructs (TEC) for cartilage, meniscal and bone repair have ...
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The Current Perspectives of Stem Cell Therapy in Orthopedic Surgery
... After high-energy trauma or gunshot injuries, bone de- fects may occur from extrusion of bony fragments. Bone defects are one of the major challenging situations of or- thopedic surgery. In this area, the first stem cell ...
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Novel regenerative therapy for acute kidney injury
... B cells were de- rived from the injected ...indicate human iPSC-derived pancreas tissues could be generated in other animals, such as pig, by blastocyst complementation, although the stromal components, ...
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Overview of stem cells and their research in burn patients
... Vascular Endothelial growth factor by cells that stimulate the formation of blood vessels. At the present moment, several different factors of this protein family has been identified. VEGF proteins serve as a part ...
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