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human proximal tubular cells

Predominant role for C5b 9 in renal ischemia/reperfusion injury

Predominant role for C5b 9 in renal ischemia/reperfusion injury

... example, human proximal tubular epithelial cells have deficient expression of the C regula- tory proteins CD55 and CD46 (53) and can activate the alternative pathway spontaneously at low ...

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Everolimus induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

Everolimus induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

... immortalized human renal epithelial proximal tubular cells ...of cells motility in WT HK2 cells treated with high concentrations of EVE (higher than 100 ...EVE-treated ...

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Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways

Berberine protects human renal proximal tubular cells from hypoxia/reoxygenation injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways

... The human renal proximal tubular cell line HK-2 was obtained from American Type Culture Collection (Manassas, VA, USA). Dulbecco Modified Eagle Medium (DMEM)/F12 and fetal bovine serum (FBS) were ...

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Original Article Necrotic epithelial cells in proximal renal tubules of 2 nd trimester fetuses: is this “acute tubular necrosis”?

Original Article Necrotic epithelial cells in proximal renal tubules of 2 nd trimester fetuses: is this “acute tubular necrosis”?

... and are not the result of autolysis. Although ATN is frequently seen in post mortem examinations of neonates, children and adults, mainly in the context of hypoxic-ischemic conditions [7, 8], we have been unable to ...

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Original Article Endocytosis mediated by Caveolin-1 inhibits activity of matrix metalloproteinase-2 in human renal proximal tubular cells under hypoxia

Original Article Endocytosis mediated by Caveolin-1 inhibits activity of matrix metalloproteinase-2 in human renal proximal tubular cells under hypoxia

... Chronic hypoxia often occurs in the kidney tis- sues of many patients with CKD. In vitro data suggest that hypoxia can induce functional and phenotypic changes in renal epithelial cells and fibroblasts, which is ...

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The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1

The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1

... occurring human CKD, as well as experimental models of renal injury ...in human cell types. Tubular epi- thelial cells exposed to TGF-β1, and other injurious factors, are believed to play a ...

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Role of p53/miR 155 5p/sirt1 loop in renal tubular injury of diabetic kidney disease

Role of p53/miR 155 5p/sirt1 loop in renal tubular injury of diabetic kidney disease

... Methods: Human renal proximal tubular (HK‑2) cells were exposed to high glucose in ...HK‑2 cells in concentration gradient, increased expression of p53 and down‑regulated expression of ...

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Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells

Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells

... Expression Assays Mm00446973_m1, Mm00435860_m1, Mm00483888_m1, Mm01256734_m1, and Mm00441242_ m1 for the detection of, respectively, TATA-binding protein (TBP), plasminogen activator inhibitor-1 (PAI-1), Collagen 1A2, ...

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Nitric Oxide Activates TGF-β/SMAD Signaling Cascade in Human Renal Proximal Tubular Cells

Nitric Oxide Activates TGF-β/SMAD Signaling Cascade in Human Renal Proximal Tubular Cells

... immunoglobulins, cells were also preincubated with isotype-specific control IgG (instead of TGF- antibody) before stimulation with ...HK-2 cells with TGF--RI kinase inhibitor totally prevented basal as ...

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Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers

Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers

... Next, a similar RNA-seq analysis was carried out on tripli- cates of RPTEC/TERT1 monolayers following 5-day expos- ure to HG and MAN conditions in the presence or absence of indirect (transwell) MSC co-culture for the ...

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Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells

Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells

... epithelial cells are polarized with structurally and functionally distinct basolateral and apical ...epithelial cells in vitro can be achieved by culturing the cells on transwell membranes where they ...

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Albumin stimulates interleukin 8 expression in proximal tubular epithelial cells in vitro and in vivo

Albumin stimulates interleukin 8 expression in proximal tubular epithelial cells in vitro and in vivo

... and tubular diseases, we examined whether IL-8 synthesis by protein-overloaded PTECs was NF- κ B ...of tubular IL-8 involves nuclear translocation of ...the human IL-8 gene contained binding sites ...

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Transforming growth Factor Beta 1 drives a switch in connexin mediated cell to cell communication in tubular cells of the diabetic kidney

Transforming growth Factor Beta 1 drives a switch in connexin mediated cell to cell communication in tubular cells of the diabetic kidney

... from tubular epithelial cells of the proximal renal ...in human primary proximal tubule epithelial cells (hPTECs) and model epithelial cells from human renal ...

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Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions

Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions

... in human PTEC is up-regulated by the inflammatory mediator IL-1α [42] and the breakdown product of C3, C3a increases vascular permeability, recruits neutrophils [43] and induces the respiratory burst in these ...

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Caveolar Endocytosis Is Critical for BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells

Caveolar Endocytosis Is Critical for BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells

... infected cells was ...infected cells declined substantially when cells were incubated with BKV and increasing doses of MBCD ...T-Ag-positive cells when HRPTEC were incubated with either MBCD ...

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Overendocytosis of gold nanoparticles increases autophagy and apoptosis in hypoxic human renal proximal tubular cells

Overendocytosis of gold nanoparticles increases autophagy and apoptosis in hypoxic human renal proximal tubular cells

... to human renal proximal tubular cells (HK-2) by Cell Counting Kit-8 assay and lactate dehydrogenase release assay, but we just found the toxic effect in the 5 nm GNP-treated cells at 50 ...

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Cytokine and Inflammatory-Related Gene Expression of Melamine Cyanurate on Human Renal Proximal Tubular Cells

Cytokine and Inflammatory-Related Gene Expression of Melamine Cyanurate on Human Renal Proximal Tubular Cells

... renal tubular obstruction when combined with the co-contaminant cyanurate ...on cells in culture and at what concentrations and ratios? These are being addressed, ...

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Dexmedetomidine provides renoprotection against ischemia reperfusion injury in mice

Dexmedetomidine provides renoprotection against ischemia reperfusion injury in mice

... Cultured human kidney proximal tubular cells (HK2) cells were treated with dexmedetomidine and the time course of phospho-a serine/threonine protein kinase (pAkt) expression in culture ...

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Original Article Ouabain-induced apoptosis and inhibition of viability of tubulointerstitial cells by regulating NKA/pSrc/pERK/ pAkt/pS6k/caspase 3 may contribute to lupus nephritis development

Original Article Ouabain-induced apoptosis and inhibition of viability of tubulointerstitial cells by regulating NKA/pSrc/pERK/ pAkt/pS6k/caspase 3 may contribute to lupus nephritis development

... tubulointerstitial cells in lupus nephritis ...HK-2 cells were treated by ouabain with concentration 0 nM (control), ...detect cells viability, AV/PI assay was conducted at 24 h to detect the cell ...

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Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells

Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells

... dependent manner reaching maximal stimulation at doses of 200-400 U/ml IL-2. Northern blot analysis demonstrated a 5.2-kb C3 mRNA species present in PTEC that was increased within 24 h of IL-2 treatment. IL-2-induced ...

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