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human recombinant IL-6

Stimulation of thrombopoiesis in mice by human recombinant interleukin 6

Stimulation of thrombopoiesis in mice by human recombinant interleukin 6

... that human recombinant IL-6 increased platelet production in mice, as measured by both peripheral platelet levels and [75Se]selenomethionine (75SeM) incorporation into newly forming ...of ...

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A Rhesus Macaque Rhadinovirus Related to Kaposi’s Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Encodes a Functional Homologue of Interleukin-6

A Rhesus Macaque Rhadinovirus Related to Kaposi’s Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Encodes a Functional Homologue of Interleukin-6

... with human herpes- virus 8 (HHV8)/Kaposi’s sarcoma-associated herpesvirus (KSHV) and encodes several analogous open reading frames (ORFs), including the homologue of cellular interleukin-6 ...RRV ...

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Phosphorylation of STAT proteins by recombinant human IL-6 in immortalized human chondrocyte cell lines, T/C28a2 and C28/I2

Phosphorylation of STAT proteins by recombinant human IL-6 in immortalized human chondrocyte cell lines, T/C28a2 and C28/I2

... Confluent cultures of T/C28a or C28/I2 chondrocytes were treated with “no additions” plus DMSO, rhIL-6 (50 ng/mL), or rhIL-6 plus Janex-1 (100 μM) and held for ~10 min at 25° (“no incubation”) or incubated ...

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IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others?

IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others?

... on recombinant and T cell derived IL-17 a: Effect of increasing concentrations of chemically-synthesised Apt21-2 (n=4) and control aptamer (n=3) on IL-6 production in IL-17A stimulated ...

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CLONING, SEQUENCING AND EXPRESSION OF THE OVINE INTERLEUKIN-6 GENE

CLONING, SEQUENCING AND EXPRESSION OF THE OVINE INTERLEUKIN-6 GENE

... to human IL 5 ...ovine IL-6 structural gene has been cloned into the yeast expression vector pOGS40, and used to produce a recom- binant ...murine IL-6 dependent cell line. This ...

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Interferon beta 2/interleukin 6 modulates synthesis of alpha 1 antitrypsin in human mononuclear phagocytes and in human hepatoma cells

Interferon beta 2/interleukin 6 modulates synthesis of alpha 1 antitrypsin in human mononuclear phagocytes and in human hepatoma cells

... the IL-1- and tumor necrosis factor-unresponsive acute phase protein alpha 1-antitrypsin (alpha 1 AT) in human hepatoma-derived hepatocytes and in human mononuclear ...Purified human ...

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Therapeutic strategies for the clinical blockade of IL 6/gp130 signaling

Therapeutic strategies for the clinical blockade of IL 6/gp130 signaling

... gp130, IL-6R displays a highly restricted expression pattern and is predominantly confined to hepatocytes, leukocyte subsets, and megakaryocytes ...54). IL-11Rα is largely confined to nonhematopoietic  ...

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Signal Transduction by Human Herpesvirus 8 Viral Interleukin-6 (vIL-6) Is Modulated by the Nonsignaling gp80 Subunit of the IL-6 Receptor Complex and Is Distinct from Signaling Induced by Human IL-6

Signal Transduction by Human Herpesvirus 8 Viral Interleukin-6 (vIL-6) Is Modulated by the Nonsignaling gp80 Subunit of the IL-6 Receptor Complex and Is Distinct from Signaling Induced by Human IL-6

... the IL-6 receptor complex can influence signal transduction by the viral ...added recombinant sgp80 (50, 100, or 200 ng/ml; R&D Systems, Minneapolis, ...

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Interleukin 26 is overexpressed in human sepsis and contributes to inflammation, organ injury, and mortality in murine sepsis

Interleukin 26 is overexpressed in human sepsis and contributes to inflammation, organ injury, and mortality in murine sepsis

... 10 6 cells) were incubated with FITC-labeled bacteria at a multipli- city of infection of 100 for 30 min at 37 ...with recombinant human IL-26 (100 ng/ml, R&D sys- tems) before infection ...
Urine interleukin 6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery

Urine interleukin 6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery

... serum/circulating IL-6 is filtered and remains intact in the urine in AKI with prox- imal tubule injury, hIL-6 was given intravenously to mice with pre-renal azotemia (renal failure without proximal ...

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The effect of interleukin 1 receptor antagonist therapy on markers of inflammation in non ST elevation acute coronary syndromes : the MRC ILA Heart Study

The effect of interleukin 1 receptor antagonist therapy on markers of inflammation in non ST elevation acute coronary syndromes : the MRC ILA Heart Study

... of IL-1ra at 14 days high-sensitive C-reactive protein was suppressed, suggesting inhibition of inflamma- tion, but by Day 30, high-sensitive C-reactive protein levels rose in the IL-1ra treated group, ...

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Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor

Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor

... Abstract: In this work, an ultrasonic spray freeze-drying (USFD) technique was used to prepare a stable liposomal dry powder for transdermal delivery of recombinant human epithe- lial growth factor (rhEGF). ...

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Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles

Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles

... Digestion of human pancreata from cadaveric donors Human cadaveric donor pancreata (n = 9) were obtained from an organ procurement organization. Cadaveric do- nors from which IPTD-MSCs were obtained ...

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GP130 activation induces myeloma and collaborates with MYC

GP130 activation induces myeloma and collaborates with MYC

... plasma cell compartment of the BM. Whereas plasma cells in nor- mal BM and in MGUS usually lacked P-STAT3 staining, 99 of 283 (35%) evaluable MM cases showed substantial nuclear P-STAT3 reactivity (Figure 1, A–E). We ...

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Interleukin 1 suppresses expression of cartilage specific types II and IX collagens and increases types I and III collagens in human chondrocytes

Interleukin 1 suppresses expression of cartilage specific types II and IX collagens and increases types I and III collagens in human chondrocytes

... is IL-1. In this study we found that recombinant human IL-1 beta suppressed synthesis of cartilage-specific type II collagen by cultured human costal chondrocytes associated with ...

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Interleukin 18 Coexpression during Respiratory Syncytial Virus Infection Results in Enhanced Disease Mediated by Natural Killer Cells

Interleukin 18 Coexpression during Respiratory Syncytial Virus Infection Results in Enhanced Disease Mediated by Natural Killer Cells

... a recombinant RSV expressing murine interleukin 18 (RSV/IL-18), a cytokine capable of inducing strong antiviral immune ...soluble IL-18. In naïve BALB/c mice, RSV/IL-18 infection significantly ...

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Interleukin (IL) 10 inhibits long term IL 6 production but not preformed mediator release from rat peritoneal mast cells

Interleukin (IL) 10 inhibits long term IL 6 production but not preformed mediator release from rat peritoneal mast cells

... to IL-10 to suppress IL-6 production, the effect of withdrawing IL-10 from LPS-activated mast cells in culture, washing cells exten- sively, and replacing with LPS-containing media in the ...

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Human recombinant granulocyte macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities

Human recombinant granulocyte macrophage colony stimulating factor and interleukin 3 have overlapping but distinct hematopoietic activities

... of human recombinant IL-3 and granulocyte- macrophage colony stimulating factor (GM-CSF) were directly compared using highly enriched human bone marrow progenitor target ...cells. IL-3 ...

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Human immunodeficiency virus Tat induces functional unresponsiveness in T cells.

Human immunodeficiency virus Tat induces functional unresponsiveness in T cells.

... The PLC g 1 pathway has been shown to play a central role in the induction of IL-2 secretion following TCR stimulation (9). Delineations of distinct signalling pathways upon T-cell activation, e.g., those of the ...

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IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

... the IL-6R from ...the IL-6R from the cell surface within 1 h [14, ...the IL-6R ...the IL-6R from neutrophils, which are the first cells to arrive at a site of damage, leads to the stimulation ...

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