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human renal proximal tubular epithelial

Caveolar Endocytosis Is Critical for BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells

Caveolar Endocytosis Is Critical for BK Virus Infection of Human Renal Proximal Tubular Epithelial Cells

... after renal transplantation has become a severe ...Since human renal proximal tubular epithelial cells (HRPTEC) represent a main natural target of BKV nephritis, analysis of BKV ...

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Everolimus induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

Everolimus induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

... although renal EMT-related effects were reached in our model only with very high concentration of this drug, we can not exclude that other different cells (including pneumocytes, bronchial epithelium cells) or pa- ...

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β2-microglobulin induces epithelial-mesenchymal transition in human renal proximal tubule epithelial cells in vitro

β2-microglobulin induces epithelial-mesenchymal transition in human renal proximal tubule epithelial cells in vitro

... HK-2 human renal proximal tubular epithelial cells (PTECs) were purchased from the American Type Culture Collection (Rockville, MD) and were maintained as described previously ...media. ...

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Original Article Necrotic epithelial cells in proximal renal tubules of 2 nd trimester fetuses: is this “acute tubular necrosis”?

Original Article Necrotic epithelial cells in proximal renal tubules of 2 nd trimester fetuses: is this “acute tubular necrosis”?

... and are not the result of autolysis. Although ATN is frequently seen in post mortem examinations of neonates, children and adults, mainly in the context of hypoxic-ischemic conditions [7, 8], we have been unable to ...

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Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells

Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells

... Previous reports have suggested the production of complement components C4, C2, and factor B by renal tissue. However, the cells involved in production of complement have not been identified. In this study ...

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Original Article Endocytosis mediated by Caveolin-1 inhibits activity of matrix metalloproteinase-2 in human renal proximal tubular cells under hypoxia

Original Article Endocytosis mediated by Caveolin-1 inhibits activity of matrix metalloproteinase-2 in human renal proximal tubular cells under hypoxia

... Chronic hypoxia often occurs in the kidney tis- sues of many patients with CKD. In vitro data suggest that hypoxia can induce functional and phenotypic changes in renal epithelial cells and fibroblasts, ...

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Transforming growth Factor Beta 1 drives a switch in connexin mediated cell to cell communication in tubular cells of the diabetic kidney

Transforming growth Factor Beta 1 drives a switch in connexin mediated cell to cell communication in tubular cells of the diabetic kidney

... from tubular epithelial cells of the proximal renal ...in human primary proximal tubule epithelial cells (hPTECs) and model epithelial cells from human ...

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Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury

Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury

... USA). Human renal proxi- mal tubule epithelial cells were purchased from Takara Bio (Otsu, ...Japan). Renal epithelial cell growth kit and medium were also purchased from Takara ...

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Predominant role for C5b 9 in renal ischemia/reperfusion injury

Predominant role for C5b 9 in renal ischemia/reperfusion injury

... to renal I/R injury was probably due to the inability to generate C5b, rather than ...example, human proximal tubular epithelial cells have deficient expression of the C regula- tory ...

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Cdc42-Interacting Protein-4 Promotes TGF-Β1-Induced Epithelial-Mesenchymal Transition and Extracellular Matrix Deposition in Renal Proximal Tubular Epithelial Cells

Cdc42-Interacting Protein-4 Promotes TGF-Β1-Induced Epithelial-Mesenchymal Transition and Extracellular Matrix Deposition in Renal Proximal Tubular Epithelial Cells

... Tubular epithelial cells are the natural in vivo targets of TGF-β1, a compound that plays a critical role in renal fibrosis in the 5/6-nephrectomy rat model ...of human CIP4 (hCIP4) in ...

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Cytokine and Inflammatory-Related Gene Expression of Melamine Cyanurate on Human Renal Proximal Tubular Cells

Cytokine and Inflammatory-Related Gene Expression of Melamine Cyanurate on Human Renal Proximal Tubular Cells

... with renal cells is modeled after our earlier work with calcium oxalate cell culture studies ...by renal tubular cells [12,14], melamine crystals caused physical damage to the cells and did not have ...

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The involvement of regulatory non coding RNAs in sepsis: a systematic review

The involvement of regulatory non coding RNAs in sepsis: a systematic review

... As sepsis progresses, the immune system is repro- grammed into a stage characterized by persistent inflam- mation and immunosuppression [69, 70]. These are mediated in part by miRNAs, which promote immune cell ...

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Hypergravity upregulates renal inducible nitric oxide synthase expression and nitric oxide production

Hypergravity upregulates renal inducible nitric oxide synthase expression and nitric oxide production

... the tubular epithelial cells, which showed significantly increased cytoplasmic iNOS immunoreactivity immediately after hypergravity exposure and a sustained, strong intensity for 6 ...exacerbate ...

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Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

... neighboring epithelial cells in the affected tissue are postulated to contribute to this ...kidney epithelial cells. Here we demonstrate that injured kidney epithelial cells assumed attributes of ...

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The acid base regulation by renal proximal tubule

The acid base regulation by renal proximal tubule

... 2011 Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis.. 2004 Mutational and functional analysis o[r] ...

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Overendocytosis of gold nanoparticles increases autophagy and apoptosis in hypoxic human renal proximal tubular cells

Overendocytosis of gold nanoparticles increases autophagy and apoptosis in hypoxic human renal proximal tubular cells

... to human renal proximal tubular cells (HK-2) by Cell Counting Kit-8 assay and lactate dehydrogenase release assay, but we just found the toxic effect in the 5 nm GNP-treated cells at 50 nM ...

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Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel

Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel

... Second, several reports have shown that oxidative stress play an important role in the impairment of renal tubular function. Glibenclamide and glimepiride were reported to stimulate ROS production in the ...

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The effect of acyclovir on the tubular secretion of creatinine in vitro

The effect of acyclovir on the tubular secretion of creatinine in vitro

... during renal tubular transport by the OCT pathway. The porcine renal tubular cell line, LLC-PK1, has been used as an in vitro renal tubular model in a vast array of ...

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Nitric Oxide Activates TGF-β/SMAD Signaling Cascade in Human Renal Proximal Tubular Cells

Nitric Oxide Activates TGF-β/SMAD Signaling Cascade in Human Renal Proximal Tubular Cells

... rat renal mesangial cells, Nitric Oxide (NO) has been shown to regulate the expression of a variety of ECM-related proteins, including matrix metalloproteinase-9 (MMP-9) [19], tissue plasminogen activator [20] and ...

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Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease

Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease

... progressive renal injury ...of renal disease in diabetic nephropathy in ZDF obese ...of renal injury in genetic salt-sensitive hypertension ...

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