human umbilical cord-MSCs
Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair
... that MSCs accomplish many of these therapeutical functions via a paracrine mechan- ism ...or MSCs can alleviate sen- escence of human cells in vitro ...of MSCs may play an important role in ...
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Human Umbilical Cord MSCs as New Cell Sources for Promoting Periodontal Regeneration in Inflammatory Periodontal Defect
... Previous studies have already demonstrated that hUCMSCs are suitable seeding cells for regeneration of multiple kinds of tissue. In a bone fracture healing animal model, one study indicated that the osteogenic ability of ...
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Human serum enhances the proliferative capacity and immunomodulatory property of MSCs derived from human placenta and umbilical cord
... that MSCs may serve as a promising tool for therapeutic application in various incurable ...of MSCs seems to be inevitable due to the requirement of sufficient numbers of MSCs for cell therapy, ...
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Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma
... that MSCs can be efficiently recruited to tumor sites, modulating tumor growth and ...that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), when mixed with human ...
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Original Article Characterization of stage-specific embryonic antigen-4 (SSEA-4)-positive very small embryonic-like stem cells isolated from human Wharton’s jelly
... Abstract: Objective: Recent studies have demonstrated that several subpopulations of adult stem cells display pluripotent properties. Methods: In this study, we isolated and characterized a small population of ...
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Quantification of the CM-Dil-labeled human umbilical cord mesenchymal stem cells migrated to the dual injured uterus in SD rat
... To assess the differentiation of the cells, the sections ob- tained from the samples on the 1st, 2nd, 3rd, and 4th weeks after hUC-MSCs injected were washed repeatedly with PBS solution to remove OCT, and then, to ...
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Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo
... cultured MSCs (human umbilical cord blood MSCs) express CCR2 and CXCR4, the respective receptors for MCP-1/CCL2 and SDF-1/CXCL12, and demonstrated, in vitro, that MCP-1/CCL2 and ...
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Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cells
... of MSCs [3–7], and hUCB- MSCs have recently been shown to have therapeutic efficacy in various disease models ...6 MSCs/kg body weight) with conventional ...
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Endocytic mechanisms and osteoinductive profile of hydroxyapatite nanoparticles in human umbilical cord Wharton’s jelly-derived mesenchymal stem cells
... Results: It was shown that both types of HANPs readily adhered to the cellular membrane and were transported into the cells compared to micro-sized HAP particles (m-HAP; 12 μm). Interest- ingly, the endocytic routes of ...
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Promoting vascular repair in the retina: can stem/progenitor cells help?
... 1) MSCs derived from bone marrow, human umbilical cord blood, and other tissues, which have been demonstrated to have neuroprotective effects, and may differentiate into other cell types, ...
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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data
... of umbilical cord tissue-derived MSCs ...and human serum is referred to as ENZ(CG) HS, and the manufac- turing process involving clinical grade enzymes and hu- man platelet lysate is referred ...
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Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells
... study MSCs were co-cultured with MNC, and the presence of other immune cells in the culture may influence NK cell ...that human embry- onic stem cell-derived mesenchymal progenitors present a stronger ...
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Long Term (Postnatal Day 70) Outcome and Safety of Intratracheal Transplantation of Human Umbilical Cord Blood Derived Mesenchymal Stem Cells in Neonatal Hyperoxic Lung Injury
... Newborn Sprague-Dawley rat pups were exposed to hy- peroxia (90% oxygen) within 10 hours of birth until P14 and were allowed to recover in room air until sacrificed at P70. Mean linear intercept (MLI) was assessed for ...
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Heterogeneity of proangiogenic features in mesenchymal stem cells derived from bone marrow, adipose tissue, umbilical cord, and placenta
... for MSCs was DMEM/F12 (DF12; Gibco, Grand Island, NY, USA), 10 % fetal bo- vine serum (FBS; HyClone), 2 mM glutamine (Sigma, ...Peprotech). Human umbilical vein endothelial cells (HUVECs) were ...
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Comparative separation methods and biological characteristics of human placental and umbilical cord mesenchymal stem cells in serum-free culture conditions
... damage MSCs, and the reproducibility of lymphocyte separations is ...DC- MSCs have reduced viability compared to UC-MSCs, and have low migration ability, and thus do not easily migrate from the ...
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Polycaprolactone nanofiber scaffold enhances the osteogenic differentiation potency of various human tissue-derived mesenchymal stem cells
... BM- MSCs has been estimated to be in the order of ...tissue-derived MSCs have been identified and investigated. Among them, umbilical cord (UC)-MSCs and adipose tissue (AD)-MSCs ...
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Regeneration of a full-thickness defect of rotator cuff tendon with freshly thawed umbilical cord-derived mesenchymal stem cells in a rat model
... UC MSCs, no difference was found in CPDL, proliferation, pluripotent stem cell markers, or differenti- ation among UCMSCs with passages 2, 3, 7, and 9, and the stemness persisted even with passaging and senes- ...
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Exposure to blue light stimulates the proangiogenic capability of exosomes derived from human umbilical cord mesenchymal stem cells
... first used to explore the basal and irradiated level of the photopigment molecules in MSCs [19]. As shown in Additional file 1: Table S1, which lists the identified hu- man opsins, gene expression of RHO , RRH , ...
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Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis
... with MSCs has focused on BM- MSCs ...other MSCs that are more readily available to replace BM-MSCs. UC-MSCs are a group of young adult MSCs derived from the neonatal ...
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Distinct immunomodulatory and migratory mechanisms underpin the therapeutic potential of human mesenchymal stem cells in autoimmune demyelination
... derived MSCs (BM-MSCs) have been widely investigated, MSCs from other tissue sources have also been shown to be effective in several autoimmune and inflammatory ...of human BM-MSCs, as ...
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