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Hydrophilic interaction liquid chromatography (HILIC)

Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted metabolomics

Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted metabolomics

... of hydrophilic interaction liquid chromatography (HILIC) with FAIMS- MS, using a miniaturised FAIMS device, was reported by Arthur et ...

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Characterization of Red Wine Proanthocyanidins Using a Putative Proanthocyanidin Database, Amide Hydrophilic Interaction Liquid Chromatography (HILIC), and Time-of-Flight Mass Spectrometry.

Characterization of Red Wine Proanthocyanidins Using a Putative Proanthocyanidin Database, Amide Hydrophilic Interaction Liquid Chromatography (HILIC), and Time-of-Flight Mass Spectrometry.

... performance liquid chromatography (UHLPC) with a hydrophilic interaction liquid chromatography (HILIC) column and coupled to a high-resolution accurate mass quadrupole ...

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Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study

Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study

... 2 Abstract Chronic kidney disease (CKD) is often characterized by a progressive loss in renal function over a period of months or years and by the accumulation of uremic retention solutes in the body. Current ...

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Evaluation of the technical variations and the suitability of a hydrophilic interaction liquid chromatography-high resolution mass spectrometry (ZIC-pHILIC-Exactive orbitrap) for clinical urinary metabolomics study

Evaluation of the technical variations and the suitability of a hydrophilic interaction liquid chromatography-high resolution mass spectrometry (ZIC-pHILIC-Exactive orbitrap) for clinical urinary metabolomics study

... of Hydrophilic Interaction Liquid Chromatography-High Resolution Mass Spectrometry (HILIC-HRMS) for untargeted metabolite profiling, here using a series of human urine samples, we investigated ...

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Effect of mobile phase additives on solute retention at low aqueous pH in hydrophilic interaction liquid chromatography

Effect of mobile phase additives on solute retention at low aqueous pH in hydrophilic interaction liquid chromatography

... Title: Effect of mobile phase additives on solute retention at low aqueous pH in hydrophilic interaction liquid chromatography.. Article Type: Full length article.[r] ...

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Understanding and manipulating the separation in hydrophilic interaction liquid chromatography

Understanding and manipulating the separation in hydrophilic interaction liquid chromatography

... plotting hydrophilic selectivity (measured from alpha cytosine/uracil) against (cat) ionic interaction (measured from alpha benzyltrimethylammonium ...both hydrophilic and structurally similar ...

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HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY (HILIC) AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS

HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY (HILIC) AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS

... HILIC method is better to use with ESI-MS. It is because highly organic mobile phase result in desolvation and hence lower detection limits. For example, retention of nicotine and continine by RP chromatography ...

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Quantitative structure retention relationships for rapid method development in hydrophilic interaction liquid chromatography of pharmaceutical compounds

Quantitative structure retention relationships for rapid method development in hydrophilic interaction liquid chromatography of pharmaceutical compounds

... 152 The model term ranking chart, presented in Figure 4.6 allows determination of the most significant factors in determining retention of analytes. The data in Figure 4.6 indicate that the linear and the quadratic terms ...

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Title: Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry

Title: Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry

... Performance parameters of the optimized RP-HPLC-UV, RP-HPLC-MS, and HILIC- HPLC-MS methods were evaluated for the 6-MMP standard present in the model (spiked) RBC lysate matrix, and the[r] ...

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Hydrophilic interaction liquid chromatography: An update

Hydrophilic interaction liquid chromatography: An update

... 2 Chromatogram of a mixture of acidic basic and neutral test compounds on a BEH amide column using 95% ACN containing 5 mM ammonium formate buffers w/w. pH 3.0, 4.4, ammonium acetate [r] ...

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A study of column equilibration time in hydrophilic interaction chromatography

A study of column equilibration time in hydrophilic interaction chromatography

... in hydrophilic interaction liquid chromatography (HILIC) was compared using the mobile phase disturbance method, column efficiency measurements and retention time ...

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DNA hydroxymethylation age of human blood determined by capillary hydrophilic-interaction liquid chromatography/mass spectrometry

DNA hydroxymethylation age of human blood determined by capillary hydrophilic-interaction liquid chromatography/mass spectrometry

... 5-hmC content has been shown to alter in mouse aging brain [27, 28]. Age-associated changes in global DNA hydroxymethylation in human are not yet known. Like 5-mC, change in 5-hmC may occur during aging, potentially ...

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Optimization of hydrophilic interaction liquid chromatographic method for simultaneous determination of cetylpyridinium chloride and benzocaine in lozenges

Optimization of hydrophilic interaction liquid chromatographic method for simultaneous determination of cetylpyridinium chloride and benzocaine in lozenges

... new Hydrophilic Interaction Liquid Chromatography (HILIC) method was developed for simulta- neous determination of cetylpyridinium chloride and benzocaine as active substances in ...

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The rise of hydrophilic interaction chromatography in untargeted clinical metabolomics

The rise of hydrophilic interaction chromatography in untargeted clinical metabolomics

... Hydrophilic interaction chromatography (HILIC) was introduced more than two decades ago and has garnered much ...a hydrophilic stationary phase used in combination with an aqueous organic ...

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Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed phase liquid chromatography

Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed phase liquid chromatography

... a hydrophilic-neutral solute (5-(hydroxymethyl)uridine), hydrophilic-weak base (cytosine), hydrophobic-strong base (nor- triptyline) and a hydrophobic-neutral ...

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Comparison of the determination of folate vitamers with hydrophilic interaction chromatography and reversed phase chromatography

Comparison of the determination of folate vitamers with hydrophilic interaction chromatography and reversed phase chromatography

... purpose hydrophilic liquid interaction chromatography, short HILIC, could be the preferred choice of ...phase liquid chromatography with the benefit of being able to retain polar ...

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Evaluating the Adsorbed Water Layer on Polar Stationary Phases for Hydrophilic Interaction Chromatography (HILIC)

Evaluating the Adsorbed Water Layer on Polar Stationary Phases for Hydrophilic Interaction Chromatography (HILIC)

... water-rich liquid layer immobilized on the surface of the polar stationary phases is critical to the retention of polar compounds in hydrophilic interaction chromatography ...

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Some factors that can lead to poor peak shape in hydrophilic interaction chromatography, and possibilities for their remediation

Some factors that can lead to poor peak shape in hydrophilic interaction chromatography, and possibilities for their remediation

... Throughout all of these studies, we exclusively used isocratic elution to minimise the influence of gradient peak compression, which may otherwise complicate the interpretation of results [13]. 2. Experimental All ...

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ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-A NEW REVOLUTION IN LIQUID CHROMATOGRAPHY

ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-A NEW REVOLUTION IN LIQUID CHROMATOGRAPHY

... (Hydrophilic-Interaction Chromatography) This column successfully improves the retention of very polar species as well as provides an orthogonal separation mode for mixtures of polar and ionisable ...

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