Hypoxia-inducible factor 1
Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α
... extensively. Indeed, estrogen and its downstream metabolite 16 a– hydroxyestrone have been demonstrated to be involved in pro-proliferative responses in PASMCs and may be involved in the development of the human disease. ...
30
Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment
... Hypoxia inducible factor-1 (HIF-1) is a transcription factor that is a major regulator of cellular adaption to low oxygen levels ...
6
Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
... escape. Hypoxia occurs during placenta and tumor development and was shown to activate ...combining hypoxia-mimicking treatment and 5-aza-2’deoxycytidine, a DNA demethylating agent used in anti-cancer ...
18
Oxygen sensing, hypoxia inducible factor 1 and the regulation of mammalian gene expression
... for hypoxia-inducible function and bound a complex termed hypoxia-inducible factor-1 (HIF-1) (Semenza and Wang, ...by hypoxia of graded severity, activation by ...
10
Molecular Docking and Drug-Likeness for the Identification of Inhibitory Action of Acetogenins from Annona Muricata as Potential Anticancer Against Hypoxia Inducible Factor 1 Alpha
... Hypoxia inducible factor 1 alpha (HIF-1a) regulates cell growth and differentiation which is implicated in human cancers. HIF-1a activates its cascade carcinogenesis mechanism in cancer cells. ...
7
Epithelial hypoxia inducible factor 1 is protective in murine experimental colitis
... implicated hypoxia in mucosal tissue damage resulting from both acute and chron- ic ...regulator hypoxia-inducible factor-1 (HIF-1) for adaptive hypoxia responses, we ...
10
Diacetoxyscirpenol as a new anticancer agent to target hypoxia- inducible factor 1
... activates hypoxia-inducible factor 1, which promotes the progression of malignancy by stimulating angiogenesis and by augmenting the ability of tumors to ...under hypoxia in cancer ...
16
Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... (D)MEM 1× high glucose (Invitrogen, Grand Island, NY) supplemented with 5% fetal bovine serum (FBS), 1% penicillin/streptomycin (P-S), and 700 μg/mL geneticin selective antibiotic ...(CDT-FBS), 1% ...
18
Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... incubated overnight at 4°C, the incubation time for HIF-1α and CAIX was 30 min at room temperature, and CD31 was incu- bated for 1 hour at room temperature. VEGF, Ki67 and p53 were detected by application of a ...
11
Development of Inhibitors Targeting Hypoxia Inducible Factor 1 and 2 for Cancer Therapy
... A number of HIF inhibitors have been synthesized or discov- ered for treating cancer, particularly for advanced and refrac- tory solid tumors. They inhibit the expression and/or functions of HIF-1α, or HIF-2α, or both, ...
8
Hypoxia inducible factor 1 controls the expression of the uncoordinated 5 B receptor, but not of Netrin 1, in first trimester human placenta
... In fact, in the first trimester placenta, HIF-1 a is expressed in syncytiotrophoblasts and in villous cytotrophoblasts (Rajakumar and Conrad, 2000). A study by Ietta et al., showed that HIF-1 a mRNA and ...
8
Surviving ischemia: adaptive responses mediated by hypoxia inducible factor 1
... Why does this response pathway fail to provide suf- ficient neovascularization in patients with coronary artery disease to prevent ischemia? One major differ- ence is that the fetal sheep heart is a growing organ that is ...
5
Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... of hypoxia-inducible factor 1 alpha (HIF-1α) and subsequent upregulation of vascular endothelial growth factor (VEGF) could contrib- ute further basement membrane damage [8]; (iii) ...
18
Endogenous Gene Regulation by DNA Binding Polyamides
... activators: hypoxia inducible factor 1 (HIF- 1) and androgen receptor ...the hypoxia response element (HRE) binds its target site with high affinity and inhibits the expression ...
11
Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology and function of tumor ...
14
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
... that hypoxia-inducible factor 1-α (HIF-1α) enhances ADORA2B expression to regulates M2 macrophage differ- entiation and production of profibrotic mediators ...
10
Pathways to Equity: An Auto-Ethnographic and Narrative Study of Teacher Educator and Preservice Teachers in a One-Credit Course and Community-Based Field Experience
... fluorescent hypoxia detection system for early recognition of hypoxic stress in encapsulated pancreatic ...and 1 million cells per capsule then incubated in either a 1% or 20% oxygen ...of ...
182
A potential function of RLIP76 in the ovarian corpus luteum
... Ral interacting protein of 76 kDa (RLIP76) is multifunctional protein localized and distributed in the plasma membrane, cytosol, and nucleus of the cell. In tumorigenesis, RLIP76 emerges as a common feature for the solid ...
8
Emerging evidence of the physiological role of hypoxia in mammary development and lactation
... During hypoxia, tissues undergo a series of physiological responses to defend themselves against a low oxygen supply, including increased angiogenesis, erythropoiesis, and glucose ...of hypoxia are mainly ...
11
Prognostic value of factors associated with hypoxia and lipid metabolism in patients with colorectal cancer
... by hypoxia, necrosis and ...with hypoxia, such as HIF1A (hypoxia-inducible factor 1-alpha) and VEGF (vascular endothelial growth factor), and with lipid metabolism, ...
6