hypoxia-inducible factor 1α (HIF-1α)
Original Article Roles of heat shock protein 70 toward hypoxia-inducible factor 1α (HIF-1α) blockade in newborn rats with hypoxia-induced pulmonary hypertension
... that hypoxia inducible factor 1α (HIF-1α) is a key transcription factor of hypoxia [2], serving important roles in the pathogenesis of HPH ...[3-5]. ...
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Involvement of human chorionic gonadotropin in regulating vasculogenic mimicry and hypoxia-inducible factor-1α expression in ovarian cancer cells
... hCG, hypoxia-inducible factor-1α (HIF-1α), and the endothelial cell markers CD31, VEGF, and factor VIII were detected by reverse transcription polymerase chain reaction ...
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Original Article 14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/ Akt/NF-кB signal transduction pathway
... of hypoxia-inducible factor-1α (HIF-1α), which is induced by hypoxia and a crucial factor for induction of tumor ...to hypoxia in our unpublished data as ...
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RETRACTED ARTICLE: Long noncoding RNA ANRIL is activated by hypoxia-inducible factor-1α and promotes osteosarcoma cell invasion and suppresses cell apoptosis upon hypoxia
... growth factor A (VEGFA), angiopoietin-like 4 (ANGPTL4), phospho- glycerate kinase 1 (PGK1), hexose kinase 2 (HK2) and car- bonic anhydrase IX (CAIX) [12], hypoxia/HIF-1α has been revealed to ...
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Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma
... the HIF-1α gene SNPs with the prog- nosis and clinicopathological characteristics of ...between HIF-1α gene SNPs and patient prognosis are summarized in Table 3 [13– ...prognostic ...
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Original Article Hypoxia-inducible factor 1α (HIF-1α) mediates the epithelial-mesenchymal transition in benign prostatic hyperplasia
... a HIF-1α signal-pathway receptor protein, has a significant role in the WSCM- induced EMT in BPH-1 ...between HIF-1α and Smad3, we performed the qPCR and western blotting to determine the ...
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Upregulated hypoxia inducible factor 1α and 2α pathway in rheumatoid arthritis and osteoarthritis
... of HIF-1α with MVD and the VEGF/KDR activated MVD in OA is consistent with the notion that VEGF is induced by hypoxia after activation of the HIF-α ...between HIF-1 α expression and the ...
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Evolution of the coordinate regulation of glycolytic enzyme genes by hypoxia
... by hypoxia in insects, fish, reptiles, birds and mammals and possibly all mobile multicellular species is multifactorial, with clear origins in the prokaryotic and fungal regulatory systems (Bacon et ...by ...
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HIF-1 and TAZ serve as reciprocal co-activators in human breast cancer cells
... Hypoxia-inducible factor 1α (HIF-1α) expression is a hallmark of intratumoral hypoxia that is associated with breast cancer metastasis and patient ...that HIF-1 ...
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Oxidation in rheumatoid arthritis
... status, and are required for normal cellular metabolism including intracellular signaling pathways and the activity of transcription factors such as NF- κ B, activator protein 1 and hypoxia-inducible ...
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Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer
... between HIF-1 b splicing variant expression, oestrogen receptors and breast cancer survi- val ...the HIF-1 a TAG sequence present in both HIF-1 a 827 and HIF-1 a 736 splice variants ...The ...
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Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry
... through hypoxia inducible factor-1α (HIF-1α) ...condition, HIF-1α is degraded within minutes through the interaction of iron and oxygen-dependent von Hippel-Lindau ...
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... the HIF-1-dependent adaptive pathway increased the serum erythropoietin (EPO) levels in severe OSAHS cases [29], indicating a potential contribution of HIF-1 to the pathogenic effects of ...in ...
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Original Article Profilin-1 mediates microvascular endothelial dysfunction in diabetic retinopathy through HIF-1α-dependent pathway
... and hypoxia inducible factor-1 alpha (HIF-1α) in cultured human retinal microvascular endothelial cells (HRMECs) treated with high glucose and in 6 month-old Sprague-Dawley (SD) rats ...
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Original Article In vivo and in vitro characteristic of HIF-1α and relative genes in ischemic femoral head necrosis
... the hypoxia-inducible factor-1 alpha (HIF-1α) was evaluated both in vivo and in vitro ...growth factor (VEGF) and apoptotic genes in chondrocytes treated with normoxia and ...
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Catabolic stress induces expression of hypoxia inducible factor (HIF) 1α in articular chondrocytes: involvement of HIF 1α in the pathogenesis of osteoarthritis
... Since HIF-1 α expression is associated with low O 2 , this factor may play a role in chondrocyte survival and the maintenance of fundamental homeostasis in the normally hypoxic articular car- ...that ...
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Cellular turnover and expression of hypoxic inducible factor in acute acalculous and calculous cholecystitis
... decreased HIF-1α expression in AAC are not clear. In a murine model, HIF expression is only sustained for a few hours in a hypoxic environment, implying that factors other than hypoxia are ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... a HIF-1 response element (Invitrogen, Grand Island, NY) or a negative control open reading frame (ORF)-free intergenic re- gion (ChIP-qPCR Human IGX1A Negative Control primers (#GPH100001C(−)01A, Qiagen, Valencia, ...
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Resveratrol Inhibits Hypoxia Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization
... inhibited hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) via the PI3K/Akt ...or hypoxia for 16 ...the hypoxia-induced ...
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Forskolin Modulates the Inhibitory Effect of C Type Natriuretic Peptide on Hypoxia Induced Atrial Dynamics and Hypoxia Inducible Factor 1 Alpha Activity
... Abstract Our study investigated effects of C-type natriuretic peptide CNP on atrial dynamics and hypoxia inducible factor 1 alpha HIF-1α activity in perfused beating rat atria, under hyp[r] ...
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