Hypoxia inducible factor 2 alpha
Duodenal hypoxia-inducible factor-2 alpha (HIF-2α) and iron-related proteins in alcoholic liver disease
... In iron-depleted cells, IRPs are induced. They bind to IREs in the 5’ or 3’ untranslated regions (UTR) in the mRNA for proteins involved in iron metabolism. Binding of the IRP to the 5’ UTR of the mRNA for ferritin, ...
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microRNA-558 facilitates the expression of hypoxia-inducible factor 2 alpha through binding to 5’-untranslated region in neuroblastoma
... that hypoxia-inducible factor 2 alpha (HIF-2α), one member of the bHLH-PAS transcription factor family, facilitates the progression of NB under non-hypoxic ...initiation ...
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Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... [2,3]. Hypoxia inhibits this process, resulting in upregulation of HIF-1 α and its downstream target genes ...hand, hypoxia-independent upregulation of HIF- 1 α may be accomplished by loss of tumor ...
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Type H blood vessels in bone modeling and remodeling
... growth factor-type BB; SLIT3, slit homolog 3 protein; HIF-1α, hypoxia-inducible factor 1-alpha; VEGF, vascular endothelial growth factor; Dll 4, delta-like protein 4; RANKL, ...
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Prognostic role of hypoxia-inducible factor-1 alpha expression in osteosarcoma: a meta-analysis
... ratios (ORs) were estimated for clinicopathological variables (age, .20 vs #20 years old; sex, male vs female; tumor stages, high vs low; metastasis, yes vs no; chemotherapy response, poor vs good; tumor size, large vs ...
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Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells
... Among different sources of mesenchymal stem cells (MSCs), dental MSCs (dental pulp, periodontal ligament, apical papilla, dental follicle, and gingival tissue) are cur- rently considered as one of the most attractive ...
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A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
... factors. Hypoxia-inducible factor-1 alpha (HIF-1 α ) is the key regulator of an- giogenesis in hypoxia, which directly and indirectly affects angiogenesis by influencing the expression ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... [1, 2] and ...of hypoxia-inducible factor 1 alpha (HIF-1α) and subsequent upregulation of vascular endothelial growth factor (VEGF) could contrib- ute further basement membrane ...
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Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer
... Human colon cancer Lovo cells were purchased from the Cell Center at the School of Basic Medicine, Peking Union Medical College (Beijing, People’s Republic of China). DMEM (Dulbecco’s Modified Eagle’s Medium) cell ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... as 2-8 days after a single oxygen microbubble ...inhibited hypoxia inducible factor-1 alpha (HIF-1 α )/vascular endothelial growth factor (VEGF) pathway to improve the morphology ...
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Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach
... in hypoxia-inducible factor 1 alpha (HIF1α) and proliferating cell nuclear antigen (PCNA) in both BxPC-3 and MIA PaCa-2 pancreatic cancer cells (Figure ...fact, hypoxia is known ...
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Original Article mRNA expression level and clinical value of hypoxia inducible factor 1 alpha in patients with myelodysplastic syndromes: a fluorescence quantitative real-time RT-PCR study
... dothelial growth factor (VEGF) and glucose transporter (GLUT). HIF-1α, which is modulated by O 2 availability, is a special subunit of HIF-1 that determines the function of HIF-1. HIF-1α, which is widely ...
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Original Article Profilin-1 mediates microvascular endothelial dysfunction in diabetic retinopathy through HIF-1α-dependent pathway
... type 2 diabetes, including primary hypertonicity, subsequent apoptosis, and angiogenesis, ...(e.g., hypoxia inducible factor-1 alpha [HIF-1α] and profilin-1, etc) are in persistent ...
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Nonhypoxic regulation and role of hypoxia inducible factor 1 in aromatase inhibitor resistant breast cancer
... one-way analysis of variance (ANOVA) with Tukey’s adjustment to compare three or more groups (for ex- ample, different treatment types, time points, and so on); and 3) a two-way ANOVA with Bonferroni ad- justment (for ...
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Hypoxia-inducible factor 1 alpha expression is an indicator of invasiveness in uterine cervical tumors
... transcription factor is one of the fundamental mediators of human tissues exposed to transcription ...tissue hypoxia is inflammation and/or circulatory failure or its ...and hypoxia have been ...
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Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species mediated B cell lymphoma extra long pathway in glioblastoma multiforme
... cycling hypoxia as well as uninterrupted hypoxia play roles in many aspects of tumor growth and development [27, ...cycling hypoxia would utilize different intracellular signaling path- ways than ...
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Oxidation in rheumatoid arthritis
... of hypoxia, or brief periods of complete anoxia, invariably lead to ...cellular hypoxia occurs frequently, both physiologically and pathologically, and serves as a potent stimulus for changes in gene ...
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Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways
... Western-blot analysis of HIF-1a and signaling protein Cells and tissues were harvested and analyzed for the ex- pression of HIF-1a, ERK, p-ERK, AKT, and p-AKT. Briefly, total protein was extracted by disrupting cells in ...
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PubMedCentral-PMC5138100.pdf
... of 2-OG to succinate and carbon dioxide [1]. The 2- OG-dependent oxygenase catalyzes the hydroxylation of proline and lysine residues, which was first identified in collagen biosynthesis ...the ...
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Hypoxia inducible factor–2 (HIF 2) regulates hepatic erythropoietin in vivo
... and PHD3) have the ability to differentially regulate HIF-1α and HIF-2α stability (61). Thus, one could imagine that com- pounds targeting individual PHD isoforms with different effi- ciencies could shift the ...
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