Hypoxia-inducible factors 1α
Science review: Redox and oxygen sensitive transcription factors in the regulation of oxidant mediated lung injury: role for hypoxia inducible factor 1α
... of inducible nitric oxide synthase and production of prostaglandins ...of inducible nitric oxide synthase during the ischemic phase of HS may involve the activation of ...of inducible nitric oxide ...
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Hypoxia Inducible Factors in Cancer and Inflammation
... Other acute and chronic inflammatory models may also prove important in furthering our understanding of how different local environments influence innate immune responses to inflammation. Importantly, HIF-1α has ...
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Upregulated hypoxia inducible factor 1α and 2α pathway in rheumatoid arthritis and osteoarthritis
... course. Hypoxia inducible factor (HIF)-1α and HIF-2α are impor- tant transcription factors, regulating VEGF gene responses to hypoxic ...
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Oxidation in rheumatoid arthritis
... status, and are required for normal cellular metabolism including intracellular signaling pathways and the activity of transcription factors such as NF- κ B, activator protein 1 and hypoxia-inducible ...
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Cellular turnover and expression of hypoxic inducible factor in acute acalculous and calculous cholecystitis
... that factors other than hypoxia are necessary for sustained elevation of HIF levels ...than hypoxia [27]. In addition, in human ischaemic coli- tis, HIF-1α is over-expressed in acutely ...
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Hypoxia-inducible factor-1α gene polymorphisms and cancer risk: a meta-analysis
... cancer risk in Caucasians. However, the sensitivity analy- sis did not suggest this association. Because the results from the sensitivity analysis were more valid, our meta- analysis does not strongly suggest the ...
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Herpesvirus entry mediator regulates hypoxia inducible factor–1α and erythropoiesis in mice
... by hypoxia-inducible factor (HIF) activity in response to low oxygen ...growth factors, also upregulate HIF activity, but it is unclear whether these signals also result in EPO production and ...
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Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice
... The expression of CD11b and CD11c on alveolar macrophages was regulated by surfac- tant protein D (SP-D) to prevent it from re- ceptor degradation (18). Surfactant protein D (SP-D) is a pulmonary collecting, which acts ...
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Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma
... This study was conducted to assess whether there is an association of the HIF-1α gene SNPs with the prog- nosis and clinicopathological characteristics of OCCCs. A significant association was observed between ...
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The role of hypoxia-inducible factors in leukemias
... drug, L-ascorbic acid in high concentrations, has also been shown to inhibit the expression of HIF-1α in CML cells. It is particularly important in CML treatment to find a molecule capable of impacting LSCs that ...
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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia inducible factor 1α
... loss. Factors contributing to hypoxia-induced weight loss are also complex and incompletely ...a hypoxia response element with an essential HIF-1 bind- ing site, and levels of IGF-BP1 correlate with ...
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Hypoxia and hypoxia-inducible factors in chronic kidney disease
... to hypoxia is impaired in the diabetic milieu and that deregulated HIF-1α may be a significant contributor [74, ...HIF- 1α with HSP40 and HSP70, leading to CHIP recruitment and polyubiquitination of ...
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Biomarkers Expression in Cervical Cancer and High Grade Squamous Intraepithelial Lesions
... angiogenic factors but also directly by hypoxia ...tissue hypoxia may also cause molecular changes associated with a more malignant phenotype less sensitive to cytotoxic and/or radiotherapy ...
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Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer
... regard, alternative splicing can modify DNA-binding properties of transcription factors [35], introduce or eliminate activating domains or increase the in vivo sta- bility of a given isoform [36]. Moreover, the ...
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A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
... giogenic factors. Hypoxia-inducible factor-1 alpha (HIF-1 α ) is the key regulator of an- giogenesis in hypoxia, which directly and indirectly affects angiogenesis by influencing the ...
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Pathways to Equity: An Auto-Ethnographic and Narrative Study of Teacher Educator and Preservice Teachers in a One-Credit Course and Community-Based Field Experience
... immunostaining fixed histological sections. However, the former approach does not easily account for the fact that functional changes may not be exhibited uniformly by all cells within a capsule, while the latter cannot ...
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Original Article Effect of hypoxia inducible factor 1α on the epithelial-mesenchymal transition of human prostate carcinoma cell and its invasion
... under hypoxia status, thus inhib- iting cell growth, differentiation and prolifera- ...under hypoxia environment, a series of signaling path- ways will be activated to induce the cell apopto- sis for ...
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Original Article Profilin-1 mediates microvascular endothelial dysfunction in diabetic retinopathy through HIF-1α-dependent pathway
... proangiogenic factors (e.g., HIF-1α and profilin-1) portray piv- otal roles in the progression of angiogenesis and represent significant targets for therapeu- tic intervention in PDR ...
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Expression of relative-protein of hypoxia-inducible factor-1α in vasculogenesis of mouse embryo
... highest expression of HIF-1α on E6.5. Our study sug- gested hypoxia relieved when embryo VM was formed after E7.5. At the same time, the embryonic cells around the LPCA were positive for VEGF and CD133. ...
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Prognostic Value of Hypoxia-Inducible Factor 1α in Solid Malignancies: A Meta-Analysis
... carcinoma and some other malignancies. However, the results are controversial or inconclusive. This discrepancy is mostly owing to the genuine heterogeneity, relatively small sample size or different detecting methods. ...
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